Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              19     665
NP_001013679                                                           18    1482
NP_003025                                                              17    3301
NP_001123986                                                           17    3301
XP_005253526                                                           17    3301
NP_667338                                                              17    4312
NP_001159608                                                           17    4312
NP_055452                                                              17    4312
NP_612154                                                              17    4312
NP_060876                                                              17    4312
NP_001139311                                                           17    4312
NP_004523                                                              17    4312
NP_005671                                                              17    4312
XP_006716547                                                           17    4312
XP_006713923                                                           17    4312
XP_006713922                                                           17    4312
NP_932349                                                              16    5631
NP_002935                                                              16    5631
NP_004761                                                              16    5631
XP_006716546                                                           16    5631
XP_006715611                                                           16    5631
NP_001181                                                              16    7355
NP_443141                                                              16    7355
NP_004382                                                              16    7355
NP_694999                                                              16    7355
NP_003120                                                              16    7355
XP_006714509                                                           16    7355
NP_733468                                                              15    9605
NP_653091                                                              15    9605
NP_002107                                                              15    9605
NP_004230                                                              15    9605
NP_065873                                                              15    9605
NP_853514                                                              15    9605
NP_001135876                                                           15    9605
NP_001135875                                                           15    9605
NP_001135874                                                           15    9605
NP_006007                                                              15    9605
NP_071418                                                              15    9605
NP_001258932                                                           15    9605
XP_006726110                                                           15    9605
XP_006726109                                                           15    9605
XP_005275388                                                           15    9605
XP_006725814                                                           15    9605
XP_006725813                                                           15    9605
XP_005268271                                                           15    9605
XP_005268270                                                           15    9605
XP_006720384                                                           15    9605
XP_006717257                                                           15    9605
XP_006717256                                                           15    9605
XP_005268418                                                           15    9605
XP_005268417                                                           15    9605
XP_005268416                                                           15    9605
XP_005247756                                                           15    9605
XP_005247755                                                           15    9605
NP_005584                                                              15    9605
NP_001135873                                                           15    9605
NP_061161                                                              15    9605
NP_072093                                                              15    9605
NP_001229687                                                           15    9605
>NP_004295
          Length = 1620

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLLWARKSL 9
           SLLWA KSL
Sbjct: 888 SLLWAGKSL 896
>NP_001013679
          Length = 385

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLWARKS 8
           +LWARKS
Sbjct: 312 ILWARKS 318
>NP_003025
          Length = 356

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SLLWARKS 8
           +LLW+RK+
Sbjct: 198 NLLWSRKT 205
>NP_001123986
          Length = 130

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLLWARKSL 9
          SLLW R+ L
Sbjct: 50 SLLWIREEL 58
>XP_005253526
          Length = 213

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SLLWARKS 8
          +LLW+RK+
Sbjct: 55 NLLWSRKT 62
>NP_667338
          Length = 1308

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LLWARK 7
            +LWARK
Sbjct: 1211 MLWARK 1216
>NP_001159608
          Length = 1228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LLWARK 7
            +LWARK
Sbjct: 1131 MLWARK 1136
>NP_055452
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SLLWARK 7
          S+LW+RK
Sbjct: 22 SVLWSRK 28
>NP_612154
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLWARKSL 9
           +LLW  KSL
Sbjct: 712 TLLWTPKSL 720
>NP_060876
          Length = 5412

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLWARKSL 9
            +LLW  KSL
Sbjct: 4999 TLLWTPKSL 5007
>NP_001139311
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SLLWARK 7
          S+LW+RK
Sbjct: 22 SVLWSRK 28
>NP_004523
          Length = 1176

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLWARKSL 9
           +LLW  KSL
Sbjct: 763 TLLWTPKSL 771
>NP_005671
          Length = 588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLLWARKSL 9
           SLLW R+++
Sbjct: 221 SLLWQREAI 229
>XP_006716547
          Length = 348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SLLWARK 7
          S+LW+RK
Sbjct: 22 SVLWSRK 28
>XP_006713923
          Length = 1228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LLWARK 7
            +LWARK
Sbjct: 1131 MLWARK 1136
>XP_006713922
          Length = 1262

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LLWARK 7
            +LWARK
Sbjct: 1211 MLWARK 1216
>NP_932349
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  WARKSL 9
          WARKS+
Sbjct: 12 WARKSV 17
>NP_002935
          Length = 2347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLLWARKS 8
           +L+WA+K+
Sbjct: 343 TLIWAKKA 350
>NP_004761
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   WARKSL 9
           WARK+L
Sbjct: 494 WARKAL 499
>XP_006716546
          Length = 741

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   WARKSL 9
           WARK+L
Sbjct: 324 WARKAL 329
>XP_006715611
          Length = 2342

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SLLWARKS 8
           +L+WA+K+
Sbjct: 352 TLIWAKKA 359
>NP_001181
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LWARKSL 9
          +WARK L
Sbjct: 9  IWARKLL 15
>NP_443141
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLLWARK 7
           SLLW R+
Sbjct: 223 SLLWTRE 229
>NP_004382
          Length = 501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLWARKSL 9
           SLLW R+ L
Sbjct: 219 SLLWPREWL 227
>NP_694999
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLLWARK 7
           SLLW R+
Sbjct: 610 SLLWRRR 616
>NP_003120
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SLLWARKS 8
           S  WARK+
Sbjct: 453 SFYWARKT 460
>XP_006714509
          Length = 1627

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLLWARK 7
           SLLW R+
Sbjct: 579 SLLWTRE 585
>NP_733468
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   LWARKSL 9
           +W RKS+
Sbjct: 873 IWGRKSV 879
>NP_653091
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   LWARKSL 9
           +W RKS+
Sbjct: 847 IWGRKSV 853
>NP_002107
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
>NP_004230
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LLWARKSL 9
           L WA+K L
Sbjct: 725 LCWAKKRL 732
>NP_065873
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    SLLWARK 7
            SL WAR+
Sbjct: 1109 SLQWARR 1115
>NP_853514
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SLLWARK 7
           +++WARK
Sbjct: 714 TVVWARK 720
>NP_001135876
          Length = 157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SLLWARKSL 9
          SLLWA   L
Sbjct: 7  SLLWAATCL 15
>NP_001135875
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SLLWARKSL 9
          SLLWA   L
Sbjct: 7  SLLWAATCL 15
>NP_001135874
          Length = 178

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SLLWARKSL 9
          SLLWA   L
Sbjct: 7  SLLWAATCL 15
>NP_006007
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SLLWARKSL 9
          SLLWA   L
Sbjct: 7  SLLWAATCL 15
>NP_071418
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 214 WPRKSL 219
>NP_001258932
          Length = 1211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    SLLWARK 7
            SL WAR+
Sbjct: 1064 SLQWARR 1070
>XP_006726110
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
>XP_006726109
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
>XP_005275388
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 326 AVMWRRKS 333
>XP_006725814
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
>XP_006725813
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
>XP_005268271
          Length = 1537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LLWARKSL 9
           L WA+K L
Sbjct: 283 LCWAKKRL 290
>XP_005268270
          Length = 1950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LLWARKSL 9
           L WA+K L
Sbjct: 696 LCWAKKRL 703
>XP_006720384
          Length = 1978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LLWARKSL 9
           L WA+K L
Sbjct: 724 LCWAKKRL 731
>XP_006717257
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SLLWARK 7
           SL WAR+
Sbjct: 936 SLQWARR 942
>XP_006717256
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    SLLWARK 7
            SL WAR+
Sbjct: 1025 SLQWARR 1031
>XP_005268418
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 339 WIRKSL 344
>XP_005268417
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 339 WIRKSL 344
>XP_005268416
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 345 WIRKSL 350
>XP_005247756
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 214 WPRKSL 219
>XP_005247755
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 214 WPRKSL 219
>NP_005584
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           S +W+RKS
Sbjct: 172 SPVWSRKS 179
>NP_001135873
          Length = 184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SLLWARKSL 9
          SLLWA   L
Sbjct: 7  SLLWAATCL 15
>NP_061161
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   WARKSL 9
           W RKSL
Sbjct: 339 WIRKSL 344
>NP_072093
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   LWARKS 8
           +WARK+
Sbjct: 459 MWARKN 464
>NP_001229687
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SLLWARKS 8
           +++W RKS
Sbjct: 329 AVMWRRKS 336
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.126    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 640,628
Number of extensions: 750
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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