Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              19     665
NP_005602                                                              18    1935
XP_005256140                                                           18    1935
NP_000029                                                              17    4312
NP_001120983                                                           17    4312
NP_001120982                                                           17    4312
NP_000043                                                              17    4312
NP_001257903                                                           17    4312
NP_001269153                                                           17    4312
NP_899662                                                              17    4312
NP_002886                                                              17    4312
XP_006723905                                                           17    4312
XP_006721269                                                           17    4312
NP_689777                                                              16    5631
NP_060360                                                              16    5631
NP_056058                                                              16    5631
NP_148936                                                              16    5631
NP_001245390                                                           16    5631
NP_006703                                                              16    5631
XP_006716574                                                           16    5631
XP_006716573                                                           16    5631
XP_005250858                                                           16    5631
XP_005250857                                                           16    5631
XP_005249990                                                           16    5631
XP_005249989                                                           16    5631
NP_003845                                                              16    7355
NP_062553                                                              16    7355
NP_001161375                                                           16    7355
NP_001276336                                                           16    7355
NP_001276335                                                           16    7355
NP_073573                                                              16    7355
NP_000139                                                              16    7355
NP_115544                                                              16    7355
NP_443134                                                              16    7355
XP_006723190                                                           16    7355
XP_006713793                                                           16    7355
XP_005264093                                                           16    7355
XP_005264092                                                           16    7355
NP_212132                                                              15    9605
NP_001258929                                                           15    9605
NP_001258930                                                           15    9605
NP_001258928                                                           15    9605
NP_149081                                                              15    9605
NP_683701                                                              15    9605
NP_055483                                                              15    9605
NP_001265659                                                           15    9605
NP_689422                                                              15    9605
NP_006469                                                              15    9605
NP_001138351                                                           15    9605
NP_689738                                                              15    9605
NP_079007                                                              15    9605
NP_001161688                                                           15    9605
NP_060625                                                              15    9605
NP_001161689                                                           15    9605
NP_001161693                                                           15    9605
XP_005256206                                                           15    9605
XP_006712399                                                           15    9605
XP_006712398                                                           15    9605
XP_006712397                                                           15    9605
XP_006712396                                                           15    9605
XP_006712395                                                           15    9605
XP_006712394                                                           15    9605
XP_005246404                                                           15    9605
XP_006711971                                                           15    9605
XP_006711970                                                           15    9605
XP_006711969                                                           15    9605
XP_005246249                                                           15    9605
XP_006711968                                                           15    9605
XP_006711967                                                           15    9605
XP_006711059                                                           15    9605
XP_005271350                                                           15    9605
XP_005271349                                                           15    9605
XP_005270933                                                           15    9605
NP_001098117                                                           15    9605
>NP_000312
          Length = 928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           SLL CALEV
Sbjct: 485 SLLACALEV 493
>NP_005602
          Length = 1139

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SLL C LEV
Sbjct: 531 SLLACCLEV 539
>XP_005256140
          Length = 1065

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SLL C LEV
Sbjct: 457 SLLACCLEV 465
>NP_000029
          Length = 2843

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           +L+ CALEV
Sbjct: 571 ALMECALEV 579
>NP_001120983
          Length = 2825

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           +L+ CALEV
Sbjct: 553 ALMECALEV 561
>NP_001120982
          Length = 2843

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           +L+ CALEV
Sbjct: 571 ALMECALEV 579
>NP_000043
          Length = 1500

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SLL+CA  V
Sbjct: 899 SLLICATHV 907
>NP_001257903
          Length = 5121

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLLVCALE 8
            SLLVC +E
Sbjct: 4133 SLLVCPME 4140
>NP_001269153
          Length = 1422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SLL+CA  V
Sbjct: 821 SLLICATHV 829
>NP_899662
          Length = 1014

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SL+ C LE+
Sbjct: 500 SLMACCLEI 508
>NP_002886
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SL+ C LE+
Sbjct: 500 SLMACCLEI 508
>XP_006723905
          Length = 896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SL+ C LE+
Sbjct: 328 SLMACCLEI 336
>XP_006721269
          Length = 5138

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SLLVCALE 8
            SLLVC +E
Sbjct: 4150 SLLVCPME 4157
>NP_689777
          Length = 3997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>NP_060360
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>NP_056058
          Length = 863

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>NP_148936
          Length = 408

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LVCALE 8
          LVCALE
Sbjct: 35 LVCALE 40
>NP_001245390
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LVCALE 8
           LVCALE
Sbjct: 176 LVCALE 181
>NP_006703
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LVCALE 8
           LVCALE
Sbjct: 176 LVCALE 181
>XP_006716574
          Length = 968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>XP_006716573
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>XP_005250858
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>XP_005250857
          Length = 4022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           ++VCALE
Sbjct: 597 MIVCALE 603
>XP_005249990
          Length = 515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LVCALE 8
           LVCALE
Sbjct: 142 LVCALE 147
>XP_005249989
          Length = 515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LVCALE 8
           LVCALE
Sbjct: 142 LVCALE 147
>NP_003845
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLLVCALEV 9
          SLL+C L +
Sbjct: 3  SLLLCGLSI 11
>NP_062553
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  LVCALE 8
          L+CALE
Sbjct: 93 LICALE 98
>NP_001161375
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLLVCAL 7
           SLL CAL
Sbjct: 377 SLLACAL 383
>NP_001276336
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLLVCAL 7
           SLL CAL
Sbjct: 294 SLLACAL 300
>NP_001276335
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLLVCAL 7
           SLL CAL
Sbjct: 270 SLLACAL 276
>NP_073573
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLLVCAL 7
           SLL CAL
Sbjct: 416 SLLACAL 422
>NP_000139
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LLVCALEV 9
          LLVC L V
Sbjct: 14 LLVCVLSV 21
>NP_115544
          Length = 830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLLVCALE 8
           +LL CALE
Sbjct: 569 NLLSCALE 576
>NP_443134
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LLVCALE 8
           LLVC LE
Sbjct: 552 LLVCPLE 558
>XP_006723190
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LLVCALEV 9
           LLVC L V
Sbjct: 137 LLVCVLSV 144
>XP_006713793
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SLLVCAL 7
           SLL CAL
Sbjct: 377 SLLACAL 383
>XP_005264093
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLLVCALEV 9
          SLL+C L +
Sbjct: 3  SLLLCGLSI 11
>XP_005264092
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLLVCALEV 9
          SLL+C L +
Sbjct: 31 SLLLCGLSI 39
>NP_212132
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1296 SLLICLLWV 1304
>NP_001258929
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1296 SLLICLLWV 1304
>NP_001258930
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1296 SLLICLLWV 1304
>NP_001258928
          Length = 2129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1327 SLLICLLWV 1335
>NP_149081
          Length = 457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>NP_683701
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>NP_055483
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>NP_001265659
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           S+++C LEV
Sbjct: 135 SVVLCLLEV 143
>NP_689422
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           S+++C LEV
Sbjct: 135 SVVLCLLEV 143
>NP_006469
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLLVCALEV 9
           S+++C LEV
Sbjct: 135 SVVLCLLEV 143
>NP_001138351
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LLVCAL 7
           LL+CAL
Sbjct: 161 LLICAL 166
>NP_689738
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>NP_079007
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SLLVCALE 8
           S  VCALE
Sbjct: 589 SACVCALE 596
>NP_001161688
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>NP_060625
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLLVCALEV 9
          ++L C LEV
Sbjct: 21 AILTCPLEV 29
>NP_001161689
          Length = 550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>NP_001161693
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_005256206
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SLLVCALE 8
           S  VCALE
Sbjct: 589 SACVCALE 596
>XP_006712399
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006712398
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006712397
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006712396
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006712395
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006712394
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_005246404
          Length = 1821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           ++ VC LEV
Sbjct: 227 NIFVCRLEV 235
>XP_006711971
          Length = 1517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_006711970
          Length = 1948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_006711969
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_005246249
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_006711968
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_006711967
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LLVCALE 8
           LLVCA++
Sbjct: 131 LLVCAVD 137
>XP_006711059
          Length = 1517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLLVCALEV 9
           SLL+C L V
Sbjct: 713 SLLICLLWV 721
>XP_005271350
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1327 SLLICLLWV 1335
>XP_005271349
          Length = 2131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLLVCALEV 9
            SLL+C L V
Sbjct: 1327 SLLICLLWV 1335
>XP_005270933
          Length = 122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LVCALEV 9
          L+C+LEV
Sbjct: 11 LMCSLEV 17
>NP_001098117
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLLVCALEV 9
          ++L C LEV
Sbjct: 21 AILTCPLEV 29
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.140    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 590,678
Number of extensions: 734
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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