Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
NP_001073922                                                           18    1935
XP_006721991                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
NP_079430                                                              17    4312
NP_001124437                                                           17    4312
NP_057305                                                              16    5631
NP_001073942                                                           16    5631
XP_005273894                                                           16    5631
XP_005268514                                                           16    5631
XP_005264358                                                           16    5631
NP_001129115                                                           16    5631
NP_001129116                                                           16    5631
NP_878253                                                              16    5631
NP_057153                                                              16    7355
NP_001188408                                                           16    7355
NP_065706                                                              15    9605
NP_001155155                                                           15    9605
NP_733764                                                              15    9605
NP_653273                                                              15    9605
XP_006723077                                                           15    9605
XP_006721300                                                           15    9605
NP_005297                                                              15    9605
NP_001073905                                                           15    9605
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1078 SLLAGLPLQ 1086
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1078 SLLAGLPLQ 1086
>NP_001073922
          Length = 2190

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SLLAGLSL 8
            SLLAGLSL
Sbjct: 2000 SLLAGLSL 2007
>XP_006721991
          Length = 1632

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1078 SLLAGLPLQ 1086
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1075 SLLAGLPLQ 1083
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1078 SLLAGLPLQ 1086
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLLAGLSLQ 9
            SLLAGL LQ
Sbjct: 1088 SLLAGLPLQ 1096
>NP_079430
          Length = 702

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LLAGLSLQ 9
           LLAGLSL+
Sbjct: 219 LLAGLSLR 226
>NP_001124437
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LLAGLSLQ 9
           LLAGLSL+
Sbjct: 302 LLAGLSLR 309
>NP_057305
          Length = 460

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           S LAGLSL+
Sbjct: 198 STLAGLSLK 206
>NP_001073942
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLLAGLSL 8
           S LAGLSL
Sbjct: 269 SFLAGLSL 276
>XP_005273894
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLAGLSLQ 9
           L+AGLS+Q
Sbjct: 95  LVAGLSMQ 102
>XP_005268514
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLLAGLSLQ 9
          S LAGLSL+
Sbjct: 55 STLAGLSLK 63
>XP_005264358
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SLLAGLSL 8
           S LAGLSL
Sbjct: 269 SFLAGLSL 276
>NP_001129115
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           S LAGLSL+
Sbjct: 205 STLAGLSLK 213
>NP_001129116
          Length = 403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           S LAGLSL+
Sbjct: 141 STLAGLSLK 149
>NP_878253
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLAGLSLQ 9
           L+AGLS+Q
Sbjct: 95  LVAGLSMQ 102
>NP_057153
          Length = 125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLLAGLSLQ 9
          S L+GLSLQ
Sbjct: 49 SNLSGLSLQ 57
>NP_001188408
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           S L+GLSLQ
Sbjct: 972 SNLSGLSLQ 980
>NP_065706
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           SLL+GL L+
Sbjct: 218 SLLSGLKLR 226
>NP_001155155
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           +LLAG+S Q
Sbjct: 373 ALLAGVSTQ 381
>NP_733764
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           +LLAG+S Q
Sbjct: 128 ALLAGVSTQ 136
>NP_653273
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLLAGLSLQ 9
           +LLAG+S Q
Sbjct: 452 ALLAGVSTQ 460
>XP_006723077
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LLAGLSLQ 9
          LLAGL+L+
Sbjct: 14 LLAGLALR 21
>XP_006721300
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SLLAGLSLQ 9
          SLL+GL L+
Sbjct: 81 SLLSGLKLR 89
>NP_005297
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLAGLSLQ 9
           LLAG+S++
Sbjct: 99  LLAGISIE 106
>NP_001073905
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LLAGLSLQ 9
          LLAGL+L+
Sbjct: 14 LLAGLALR 21
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.133    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 363,973
Number of extensions: 560
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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