Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_009046                                                              17    2528
NP_001004488                                                           17    2528
NP_001139241                                                           17    4312
NP_004619                                                              17    4312
NP_003030                                                              16    5631
NP_064707                                                              16    5631
XP_005246155                                                           16    5631
XP_006712703                                                           16    5631
XP_005246154                                                           16    5631
XP_006710899                                                           16    5631
XP_005263548                                                           16    5631
NP_005250                                                              16    7355
NP_001005182                                                           16    7355
NP_079235                                                              16    7355
NP_003599                                                              16    7355
XP_006719671                                                           16    7355
NP_001005185                                                           16    7355
NP_795713                                                              16    7355
NP_036196                                                              15    9605
NP_001185791                                                           15    9605
NP_060722                                                              15    9605
NP_001010986                                                           15    9605
NP_775965                                                              15    9605
NP_697018                                                              15    9605
NP_006802                                                              15    9605
NP_001258138                                                           15    9605
NP_945179                                                              15    9605
NP_076979                                                              15    9605
NP_695021                                                              15    9605
XP_006724816                                                           15    9605
XP_006724815                                                           15    9605
XP_006724814                                                           15    9605
XP_005262462                                                           15    9605
XP_005271350                                                           15    9605
>NP_009046
          Length = 277

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  LIYIFLLI 9
          LIY+FLL+
Sbjct: 4  LIYLFLLL 11
>NP_001004488
          Length = 310

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SLIYIFLLI 9
          SL YIF+L+
Sbjct: 31 SLFYIFILL 39
>NP_001139241
          Length = 903

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           L++IFLLI
Sbjct: 261 LVHIFLLI 268
>NP_004619
          Length = 940

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           L++IFLLI
Sbjct: 298 LVHIFLLI 305
>NP_003030
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYIFLLI 9
           IYIFL++
Sbjct: 454 IYIFLIV 460
>NP_064707
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLIYIFLLI 9
          S IYIF+ +
Sbjct: 48 SFIYIFIFV 56
>XP_005246155
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLIYIFLLI 9
          S IYIF+ +
Sbjct: 48 SFIYIFIFV 56
>XP_006712703
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLIYIFLLI 9
          S IYIF+ +
Sbjct: 48 SFIYIFIFV 56
>XP_005246154
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SLIYIFLLI 9
          S IYIF+ +
Sbjct: 48 SFIYIFIFV 56
>XP_006710899
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYIFLLI 9
           IYIFL++
Sbjct: 444 IYIFLIV 450
>XP_005263548
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYIFLLI 9
           IYIFL++
Sbjct: 454 IYIFLIV 460
>NP_005250
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYIFLLI 9
          IY+F+LI
Sbjct: 10 IYLFMLI 16
>NP_001005182
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LIYIFLLI 9
          +I++FLLI
Sbjct: 24 VIFVFLLI 31
>NP_079235
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           L+Y+FL++
Sbjct: 107 LLYLFLIL 114
>NP_003599
          Length = 337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  LIYIFLLI 9
          ++YIF++I
Sbjct: 19 IVYIFVII 26
>XP_006719671
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           L+Y+FL++
Sbjct: 107 LLYLFLIL 114
>NP_001005185
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IYIFLLI 9
          IY+FLL+
Sbjct: 25 IYLFLLL 31
>NP_795713
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LIYIFL 7
           LIYIFL
Sbjct: 315 LIYIFL 320
>NP_036196
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLIYIFLL 8
           SL+Y FLL
Sbjct: 216 SLLYDFLL 223
>NP_001185791
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           LI+I+LL+
Sbjct: 131 LIFIYLLL 138
>NP_060722
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LIYIFLLI 9
          LI+I+LL+
Sbjct: 70 LIFIYLLL 77
>NP_001010986
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 296 IVYLFILL 303
>NP_775965
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 296 IVYLFILL 303
>NP_697018
          Length = 88

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIYIFLLI 9
          L+Y+FL I
Sbjct: 3  LLYLFLAI 10
>NP_006802
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIYIFLLI 9
          LIY F+L+
Sbjct: 40 LIYAFILL 47
>NP_001258138
          Length = 87

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIYIFLLI 9
          L+Y+FL I
Sbjct: 3  LLYLFLAI 10
>NP_945179
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIYIFLLI 9
          LIY F+L+
Sbjct: 40 LIYAFILL 47
>NP_076979
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLIYIFLL 8
           SLI+IF L
Sbjct: 211 SLIFIFTL 218
>NP_695021
          Length = 84

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIYIFLLI 9
          L+Y+FL I
Sbjct: 3  LLYLFLAI 10
>XP_006724816
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 293 IVYLFILL 300
>XP_006724815
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 293 IVYLFILL 300
>XP_006724814
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 293 IVYLFILL 300
>XP_005262462
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 8/8 (100%)

Query: 2   LIYIFLLI 9
           ++Y+F+L+
Sbjct: 293 IVYLFILL 300
>XP_005271350
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LIYIFL 7
            L+YIFL
Sbjct: 1830 LVYIFL 1835
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.357    0.178    0.481 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 382,889
Number of extensions: 801
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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