Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     869
XP_005273257                                                           19     869
NP_973730                                                              17    2528
NP_001974                                                              17    2528
NP_001159521                                                           17    2528
XP_005258694                                                           17    2528
XP_005258693                                                           17    2528
XP_005258692                                                           17    2528
XP_005258691                                                           17    2528
NP_775752                                                              17    4312
XP_005259550                                                           17    4312
NP_068570                                                              16    5631
NP_851564                                                              16    5631
NP_851565                                                              16    5631
NP_056078                                                              16    7355
NP_006786                                                              16    7355
NP_001167587                                                           16    7355
NP_001167588                                                           16    7355
NP_001269373                                                           16    7355
NP_038476                                                              16    7355
NP_872589                                                              16    7355
NP_001269374                                                           16    7355
XP_005254315                                                           16    7355
XP_005254314                                                           16    7355
XP_006720509                                                           16    7355
XP_005254313                                                           16    7355
XP_005254312                                                           16    7355
XP_006718487                                                           16    7355
NP_008941                                                              15    9605
NP_001278405                                                           15    9605
NP_775267                                                              15    9605
NP_775268                                                              15    9605
NP_775266                                                              15    9605
NP_004094                                                              15    9605
NP_001009923                                                           15    9605
NP_001163801                                                           15    9605
XP_006725362                                                           15    9605
XP_006721713                                                           15    9605
XP_005273505                                                           15    9605
XP_005273504                                                           15    9605
NP_001073937                                                           15    9605
>NP_064450
          Length = 1722

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SLIVSPRR 8
           SLIVSPRR
Sbjct: 786 SLIVSPRR 793
>XP_005273257
          Length = 1726

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SLIVSPRR 8
           SLIVSPRR
Sbjct: 790 SLIVSPRR 797
>NP_973730
          Length = 323

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>NP_001974
          Length = 297

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>NP_001159521
          Length = 273

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>XP_005258694
          Length = 299

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>XP_005258693
          Length = 323

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>XP_005258692
          Length = 323

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>XP_005258691
          Length = 323

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SLIVSPRRK 9
           S+IVSPR++
Sbjct: 100 SIIVSPRQR 108
>NP_775752
          Length = 679

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLIVSPRRK 9
           SLI +PRR+
Sbjct: 335 SLITAPRRE 343
>XP_005259550
          Length = 666

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLIVSPRRK 9
           SLI +PRR+
Sbjct: 335 SLITAPRRE 343
>NP_068570
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VSPRRK 9
           VSPRRK
Sbjct: 169 VSPRRK 174
>NP_851564
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VSPRRK 9
           VSPRRK
Sbjct: 169 VSPRRK 174
>NP_851565
          Length = 560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VSPRRK 9
           VSPRRK
Sbjct: 191 VSPRRK 196
>NP_056078
          Length = 3036

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2391 LVVKPRRQ 2398
>NP_006786
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           +L+V PRR
Sbjct: 113 ALVVDPRR 120
>NP_001167587
          Length = 3037

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2392 LVVKPRRQ 2399
>NP_001167588
          Length = 2400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 1755 LVVKPRRQ 1762
>NP_001269373
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           +L+V PRR
Sbjct: 113 ALVVDPRR 120
>NP_038476
          Length = 1556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IVSPRRK 9
            ++SPRRK
Sbjct: 1351 LLSPRRK 1357
>NP_872589
          Length = 1524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IVSPRRK 9
            ++SPRRK
Sbjct: 1319 LLSPRRK 1325
>NP_001269374
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           +L+V PRR
Sbjct: 127 ALVVDPRR 134
>XP_005254315
          Length = 2576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2392 LVVKPRRQ 2399
>XP_005254314
          Length = 2605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2392 LVVKPRRQ 2399
>XP_006720509
          Length = 2646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2392 LVVKPRRQ 2399
>XP_005254313
          Length = 3057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2391 LVVKPRRQ 2398
>XP_005254312
          Length = 3058

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVSPRRK 9
            L+V PRR+
Sbjct: 2392 LVVKPRRQ 2399
>XP_006718487
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           +L+V PRR
Sbjct: 113 ALVVDPRR 120
>NP_008941
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLIVSPRRK 9
           +LI+SP R+
Sbjct: 237 ALIISPTRE 245
>NP_001278405
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLIVSPRRK 9
           +LI+SP R+
Sbjct: 129 ALIISPTRE 137
>NP_775267
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>NP_775268
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>NP_775266
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>NP_004094
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>NP_001009923
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SLIVSPR 7
          SL++SPR
Sbjct: 25 SLVLSPR 31
>NP_001163801
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LIVSPRRK 9
          + +SPRRK
Sbjct: 44 ITLSPRRK 51
>XP_006725362
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SLIVSPRRK 9
          +LI+SP R+
Sbjct: 51 ALIISPTRE 59
>XP_006721713
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SLIVSPRRK 9
          +LI+SP R+
Sbjct: 51 ALIISPTRE 59
>XP_005273505
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>XP_005273504
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLIVSPRR 8
           SLI+ PR+
Sbjct: 361 SLIIHPRK 368
>NP_001073937
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  SLIVSPR 7
          SL+V+PR
Sbjct: 79 SLVVAPR 85
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.135    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 723,551
Number of extensions: 767
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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