Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           19     869
NP_001020014                                                           19     869
NP_055903                                                              19     869
NP_055426                                                              17    2528
XP_005248757                                                           17    2528
XP_006715468                                                           17    2528
XP_005248756                                                           17    2528
XP_006715467                                                           17    2528
NP_079165                                                              17    4312
NP_872407                                                              17    4312
XP_005270220                                                           17    4312
XP_005270219                                                           17    4312
NP_001275918                                                           16    5631
NP_001159451                                                           16    5631
NP_055031                                                              16    5631
NP_001136065                                                           16    5631
NP_001136066                                                           16    5631
NP_057425                                                              16    5631
XP_006717953                                                           16    5631
XP_006717952                                                           16    5631
XP_006717951                                                           16    5631
XP_006717950                                                           16    5631
XP_006717949                                                           16    5631
XP_006717948                                                           16    5631
NP_663761                                                              16    5631
NP_054733                                                              16    7355
NP_002145                                                              16    7355
NP_061927                                                              16    7355
XP_006717969                                                           16    7355
XP_005269977                                                           16    7355
XP_006717968                                                           16    7355
XP_006717967                                                           16    7355
XP_006717966                                                           16    7355
XP_006717965                                                           16    7355
NP_004949                                                              15    9605
NP_065805                                                              15    9605
NP_775656                                                              15    9605
NP_002596                                                              15    9605
NP_005723                                                              15    9605
NP_001230066                                                           15    9605
NP_001243089                                                           15    9605
NP_079273                                                              15    9605
NP_060907                                                              15    9605
NP_932095                                                              15    9605
NP_892121                                                              15    9605
NP_056311                                                              15    9605
XP_006724601                                                           15    9605
XP_006721016                                                           15    9605
XP_006720630                                                           15    9605
XP_005254990                                                           15    9605
XP_005252145                                                           15    9605
XP_006717237                                                           15    9605
XP_005252143                                                           15    9605
XP_005247728                                                           15    9605
XP_006713777                                                           15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLETDQNQS 9
            SLET QNQS
Sbjct: 1748 SLETGQNQS 1756
>NP_001020014
          Length = 1029

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLETDQNQS 9
           SLET QNQS
Sbjct: 944 SLETGQNQS 952
>NP_055903
          Length = 1723

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SLETDQNQS 9
            SLET QNQS
Sbjct: 1638 SLETGQNQS 1646
>NP_055426
          Length = 5596

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETDQNQS 9
            ETDQN+S
Sbjct: 4929 ETDQNES 4935
>XP_005248757
          Length = 3591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETDQNQS 9
            ETDQN+S
Sbjct: 2924 ETDQNES 2930
>XP_006715468
          Length = 3744

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETDQNQS 9
            ETDQN+S
Sbjct: 3077 ETDQNES 3083
>XP_005248756
          Length = 3905

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETDQNQS 9
            ETDQN+S
Sbjct: 3238 ETDQNES 3244
>XP_006715467
          Length = 5550

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ETDQNQS 9
            ETDQN+S
Sbjct: 4929 ETDQNES 4935
>NP_079165
          Length = 363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          S+E DQN S
Sbjct: 70 SIEIDQNSS 78
>NP_872407
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          S+E DQN S
Sbjct: 64 SIEIDQNSS 72
>XP_005270220
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          S+E DQN S
Sbjct: 70 SIEIDQNSS 78
>XP_005270219
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          S+E DQN S
Sbjct: 70 SIEIDQNSS 78
>NP_001275918
          Length = 2286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>NP_001159451
          Length = 1994

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 472 SLETDEEDS 480
>NP_055031
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LETDQNQS 9
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_001136065
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LETDQNQS 9
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_001136066
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  LETDQNQS 9
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_057425
          Length = 2302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>XP_006717953
          Length = 2008

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 472 SLETDEEDS 480
>XP_006717952
          Length = 2300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>XP_006717951
          Length = 2315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>XP_006717950
          Length = 2316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>XP_006717949
          Length = 2316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>XP_006717948
          Length = 2316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SLETDQNQS 9
           SLETD+  S
Sbjct: 780 SLETDEEDS 788
>NP_663761
          Length = 525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLETDQNQS 9
           +LETDQ+ S
Sbjct: 192 TLETDQSTS 200
>NP_054733
          Length = 2136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SLETDQN 7
           +LETD+N
Sbjct: 492 ALETDEN 498
>NP_002145
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           +ETDQN
Sbjct: 510 METDQN 515
>NP_061927
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 706 LETDENR 712
>XP_006717969
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 310 LETDENR 316
>XP_005269977
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 426 LETDENR 432
>XP_006717968
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717967
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717966
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717965
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           LETD+N+
Sbjct: 829 LETDENR 835
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           L+T+QNQ
Sbjct: 872 LKTEQNQ 878
>NP_065805
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLETDQNQ 8
           SLE D+N+
Sbjct: 223 SLENDENR 230
>NP_775656
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ETDQNQ 8
           ETD+NQ
Sbjct: 650 ETDKNQ 655
>NP_002596
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ETDQNQ 8
           ETD+NQ
Sbjct: 696 ETDKNQ 701
>NP_005723
          Length = 1312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TDQNQS 9
           TD+NQS
Sbjct: 674 TDENQS 679
>NP_001230066
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ETDQNQ 8
           ETD+NQ
Sbjct: 624 ETDKNQ 629
>NP_001243089
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLETDQNQS 9
           +L +DQN+S
Sbjct: 439 NLSSDQNKS 447
>NP_079273
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLETDQNQS 9
           +L +DQN+S
Sbjct: 439 NLSSDQNKS 447
>NP_060907
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           L+TDQN
Sbjct: 272 LDTDQN 277
>NP_932095
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           L+TDQN
Sbjct: 272 LDTDQN 277
>NP_892121
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          SLE D+N S
Sbjct: 89 SLEYDENTS 97
>NP_056311
          Length = 1812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SLETDQNQS 9
          SLE D+N S
Sbjct: 89 SLEYDENTS 97
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           +ETDQN
Sbjct: 749 VETDQN 754
>XP_006721016
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SLETDQNQS 9
           +L +DQN+S
Sbjct: 439 NLSSDQNKS 447
>XP_006720630
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ETDQNQ 8
           ETD+NQ
Sbjct: 449 ETDKNQ 454
>XP_005254990
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   ETDQNQ 8
           ETD+NQ
Sbjct: 506 ETDKNQ 511
>XP_005252145
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           L+TDQN
Sbjct: 97  LDTDQN 102
>XP_006717237
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           L+TDQN
Sbjct: 272 LDTDQN 277
>XP_005252143
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LETDQN 7
           L+TDQN
Sbjct: 272 LDTDQN 277
>XP_005247728
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLETDQNQ 8
           SLE D+N+
Sbjct: 192 SLENDENR 199
>XP_006713777
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SLETDQNQ 8
           SLE D+N+
Sbjct: 223 SLENDENR 230
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           L+T+QNQ
Sbjct: 645 LKTEQNQ 651
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LETDQNQ 8
           L+T+QNQ
Sbjct: 872 LKTEQNQ 878
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0990    0.224 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 552,548
Number of extensions: 1095
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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