Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           18    1135
NP_000133                                                              18    1135
NP_075254                                                              18    1135
XP_006713936                                                           18    1135
XP_006713935                                                           18    1135
XP_006713934                                                           18    1135
XP_006713933                                                           18    1135
XP_006713932                                                           18    1135
XP_006713931                                                           18    1135
NP_001139145                                                           17    4312
NP_005286                                                              17    4312
XP_006714452                                                           17    4312
XP_005263364                                                           17    4312
XP_005263363                                                           17    4312
XP_005263362                                                           17    4312
XP_006714426                                                           17    4312
XP_006714423                                                           17    4312
XP_006714422                                                           17    4312
XP_006714421                                                           17    4312
XP_006714420                                                           17    4312
XP_006714419                                                           17    4312
XP_006714418                                                           17    4312
XP_006714417                                                           17    4312
XP_005263359                                                           17    4312
XP_006714416                                                           17    4312
XP_006714415                                                           17    4312
XP_006714414                                                           17    4312
XP_006714413                                                           17    4312
XP_006714412                                                           17    4312
XP_006714411                                                           17    4312
XP_006714410                                                           17    4312
XP_006714409                                                           17    4312
XP_006714408                                                           17    4312
NP_814444                                                              16    7355
NP_004596                                                              16    7355
NP_001230328                                                           16    7355
NP_932066                                                              16    7355
NP_057150                                                              16    7355
XP_005259239                                                           16    7355
XP_006716001                                                           16    7355
XP_005245288                                                           16    7355
NP_000836                                                              16    7355
NP_060250                                                              15    9605
XP_006716523                                                           15    9605
XP_006716522                                                           15    9605
XP_005251324                                                           15    9605
XP_005251323                                                           15    9605
>NP_001156685
          Length = 808

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 426 SLESNASMS 434
>NP_000133
          Length = 806

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 424 SLESNASMS 432
>NP_075254
          Length = 694

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 312 SLESNASMS 320
>XP_006713936
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 424 SLESNASMS 432
>XP_006713935
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 425 SLESNASMS 433
>XP_006713934
          Length = 809

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 426 SLESNASMS 434
>XP_006713933
          Length = 810

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 427 SLESNASMS 435
>XP_006713932
          Length = 810

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 428 SLESNASMS 436
>XP_006713931
          Length = 811

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           SLESN SMS
Sbjct: 428 SLESNASMS 436
>NP_001139145
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLESNTSMS 9
          S ESNT+MS
Sbjct: 14 SEESNTTMS 22
>NP_005286
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SLESNTSM 8
           SLESNT++
Sbjct: 106 SLESNTAL 113
>XP_006714452
          Length = 707

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_005263364
          Length = 959

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_005263363
          Length = 1092

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_005263362
          Length = 1117

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714426
          Length = 1145

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714423
          Length = 1265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLESNTSMS 9
          S ESNT+MS
Sbjct: 14 SEESNTTMS 22
>XP_006714422
          Length = 1242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714421
          Length = 1254

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714420
          Length = 1265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLESNTSMS 9
          S ESNT+MS
Sbjct: 14 SEESNTTMS 22
>XP_006714419
          Length = 1265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SLESNTSMS 9
          S ESNT+MS
Sbjct: 14 SEESNTTMS 22
>XP_006714418
          Length = 1300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714417
          Length = 1319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_005263359
          Length = 1340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714416
          Length = 1346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 95  SEESNTTMS 103
>XP_006714415
          Length = 1347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714414
          Length = 1369

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 118 SEESNTTMS 126
>XP_006714413
          Length = 1369

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 118 SEESNTTMS 126
>XP_006714412
          Length = 1372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714411
          Length = 1377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 126 SEESNTTMS 134
>XP_006714410
          Length = 1385

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714409
          Length = 1400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>XP_006714408
          Length = 1400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLESNTSMS 9
           S ESNT+MS
Sbjct: 149 SEESNTTMS 157
>NP_814444
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLESNTSM 8
           SLE NTS+
Sbjct: 332 SLEPNTSL 339
>NP_004596
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLESNTSM 8
           SLE NTS+
Sbjct: 317 SLEPNTSL 324
>NP_001230328
          Length = 124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2 LESNTSMS 9
         +ESNTS S
Sbjct: 1 MESNTSSS 8
>NP_932066
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LESNTSMS 9
          +ESNTS S
Sbjct: 41 MESNTSSS 48
>NP_057150
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LESNTSMS 9
          +ESNTS S
Sbjct: 42 MESNTSSS 49
>XP_005259239
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SLESNTSM 8
           SLE NTS+
Sbjct: 188 SLEPNTSL 195
>XP_006716001
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLESNTS 7
           SLE+NTS
Sbjct: 888 SLETNTS 894
>XP_005245288
          Length = 124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2 LESNTSMS 9
         +ESNTS S
Sbjct: 1 MESNTSSS 8
>NP_000836
          Length = 908

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SLESNTS 7
           SLE+NTS
Sbjct: 888 SLETNTS 894
>NP_060250
          Length = 2997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ESNTSMS 9
            ESN SMS
Sbjct: 2271 ESNASMS 2277
>XP_006716523
          Length = 1912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ESNTSMS 9
            ESN SMS
Sbjct: 1186 ESNASMS 1192
>XP_006716522
          Length = 2192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ESNTSMS 9
            ESN SMS
Sbjct: 1466 ESNASMS 1472
>XP_005251324
          Length = 2996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ESNTSMS 9
            ESN SMS
Sbjct: 2270 ESNASMS 2276
>XP_005251323
          Length = 2997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    ESNTSMS 9
            ESN SMS
Sbjct: 2271 ESNASMS 2277
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.272   0.0864    0.178 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,218
Number of extensions: 222
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package