Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              18    1482
NP_001278350                                                           17    3301
NP_001278347                                                           17    3301
NP_001278346                                                           17    3301
NP_066963                                                              17    3301
NP_001278345                                                           17    3301
NP_001278344                                                           17    3301
NP_079160                                                              17    3301
XP_005272716                                                           17    3301
XP_005272715                                                           17    3301
XP_005272713                                                           17    3301
XP_005268134                                                           17    3301
XP_005268132                                                           17    3301
NP_001123475                                                           17    4312
NP_653243                                                              17    4312
NP_079350                                                              16    5631
XP_006714380                                                           16    5631
XP_006714379                                                           16    5631
XP_006714378                                                           16    5631
XP_006714377                                                           16    5631
NP_694972                                                              16    7355
NP_001091846                                                           15    9605
NP_001010890                                                           15    9605
NP_001009611                                                           15    9605
NP_001139816                                                           15    9605
NP_001093322                                                           15    9605
NP_001013425                                                           15    9605
NP_078872                                                              15    9605
NP_037431                                                              15    9605
NP_001017991                                                           15    9605
NP_001245198                                                           15    9605
NP_001245184                                                           15    9605
NP_001245187                                                           15    9605
NP_001245186                                                           15    9605
NP_001245185                                                           15    9605
NP_001245188                                                           15    9605
NP_001245196                                                           15    9605
NP_001245189                                                           15    9605
NP_001245190                                                           15    9605
NP_001245195                                                           15    9605
NP_001245180                                                           15    9605
NP_001245197                                                           15    9605
NP_001245179                                                           15    9605
NP_001245194                                                           15    9605
NP_001245183                                                           15    9605
NP_001245191                                                           15    9605
NP_001245199                                                           15    9605
NP_001245193                                                           15    9605
NP_001245178                                                           15    9605
NP_001245182                                                           15    9605
NP_001245181                                                           15    9605
NP_009056                                                              15    9605
NP_001245192                                                           15    9605
NP_872601                                                              15    9605
NP_872600                                                              15    9605
NP_001017990                                                           15    9605
XP_006726395                                                           15    9605
XP_005276181                                                           15    9605
XP_005276180                                                           15    9605
XP_005276179                                                           15    9605
XP_006725019                                                           15    9605
XP_006725018                                                           15    9605
XP_006724939                                                           15    9605
XP_005262575                                                           15    9605
XP_006724938                                                           15    9605
XP_005274018                                                           15    9605
XP_005274017                                                           15    9605
XP_005266092                                                           15    9605
XP_005266091                                                           15    9605
XP_006711146                                                           15    9605
XP_006711145                                                           15    9605
XP_006711143                                                           15    9605
NP_001010889                                                           15    9605
NP_542451                                                              15    9605
>NP_002430
          Length = 1137

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           SLAA IKYL
Sbjct: 502 SLAAIIKYL 510
>NP_001278350
          Length = 1105

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 138 ALAARIKYL 146
>NP_001278347
          Length = 1322

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>NP_001278346
          Length = 1356

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>NP_066963
          Length = 1401

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>NP_001278345
          Length = 1408

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>NP_001278344
          Length = 1453

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>NP_079160
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAATIKYL 9
           L AT+KYL
Sbjct: 378 LGATVKYL 385
>XP_005272716
          Length = 1367

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>XP_005272715
          Length = 1374

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>XP_005272713
          Length = 1419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IKYL
Sbjct: 389 ALAARIKYL 397
>XP_005268134
          Length = 281

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAATIKYL 9
           L AT+KYL
Sbjct: 196 LGATVKYL 203
>XP_005268132
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAATIKYL 9
           L AT+KYL
Sbjct: 378 LGATVKYL 385
>NP_001123475
          Length = 285

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           SLAAT+ Y+
Sbjct: 113 SLAATVVYI 121
>NP_653243
          Length = 265

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           SLAAT+ Y+
Sbjct: 93  SLAATVVYI 101
>NP_079350
          Length = 4012

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLAATIKYL 9
            S  AT+KYL
Sbjct: 3320 SFIATLKYL 3328
>XP_006714380
          Length = 3897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLAATIKYL 9
            S  AT+KYL
Sbjct: 3205 SFIATLKYL 3213
>XP_006714379
          Length = 3936

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLAATIKYL 9
            S  AT+KYL
Sbjct: 3244 SFIATLKYL 3252
>XP_006714378
          Length = 3965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLAATIKYL 9
            S  AT+KYL
Sbjct: 3273 SFIATLKYL 3281
>XP_006714377
          Length = 4010

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SLAATIKYL 9
            S  AT+KYL
Sbjct: 3318 SFIATLKYL 3326
>NP_694972
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SLAATIKYL 9
            SLA T+K+L
Sbjct: 1175 SLAYTVKHL 1183
>NP_001091846
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>NP_001010890
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>NP_001009611
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>NP_001139816
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>NP_001093322
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 347 VAATLEYL 354
>NP_001013425
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 348 VAATLEYL 355
>NP_078872
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ATIKYL 9
           AT+KYL
Sbjct: 806 ATVKYL 811
>NP_037431
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          L AT++YL
Sbjct: 75 LLATVRYL 82
>NP_001017991
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          LAA I+YL
Sbjct: 56 LAAVIEYL 63
>NP_001245198
          Length = 1293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245184
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245187
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245186
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245185
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245188
          Length = 1331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 370 TLAARIKFL 378
>NP_001245196
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245189
          Length = 1377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245190
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 353 TLAARIKFL 361
>NP_001245195
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245180
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245197
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245179
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 370 TLAARIKFL 378
>NP_001245194
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 303 TLAARIKFL 311
>NP_001245183
          Length = 1211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245191
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245199
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245193
          Length = 1376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 370 TLAARIKFL 378
>NP_001245178
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245182
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245181
          Length = 1392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_009056
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001245192
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_872601
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_872600
          Length = 1240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>NP_001017990
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          LAA I+YL
Sbjct: 56 LAAVIEYL 63
>XP_006726395
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 349 VAATLEYL 356
>XP_005276181
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_005276180
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_005276179
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_006725019
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_006725018
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_006724939
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>XP_005262575
          Length = 1182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>XP_006724938
          Length = 1234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SLAATIKYL 9
           +LAA IK+L
Sbjct: 386 TLAARIKFL 394
>XP_005274018
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          L AT++YL
Sbjct: 75 LLATVRYL 82
>XP_005274017
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          L AT++YL
Sbjct: 75 LLATVRYL 82
>XP_005266092
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ATIKYL 9
           AT+KYL
Sbjct: 421 ATVKYL 426
>XP_005266091
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ATIKYL 9
           AT+KYL
Sbjct: 806 ATVKYL 811
>XP_006711146
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_006711145
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>XP_006711143
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 350 VAATLEYL 357
>NP_001010889
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LAATIKYL 9
           +AAT++YL
Sbjct: 348 VAATLEYL 355
>NP_542451
          Length = 115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LAATIKYL 9
          LAA I+YL
Sbjct: 56 LAAVIEYL 63
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.128    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 309,252
Number of extensions: 359
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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