Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              21     175
NP_001275962                                                           17    4312
NP_001275961                                                           17    4312
NP_006206                                                              17    4312
NP_056142                                                              16    5631
XP_006711311                                                           16    5631
XP_005245106                                                           16    5631
NP_112503                                                              16    7355
NP_000094                                                              16    7355
NP_000615                                                              16    7355
NP_000809                                                              16    7355
XP_006720469                                                           16    7355
XP_005254249                                                           16    7355
XP_005254248                                                           16    7355
XP_005254247                                                           16    7355
NP_001127838                                                           16    7355
NP_001273886                                                           15    9605
NP_149115                                                              15    9605
NP_001207423                                                           15    9605
NP_001207425                                                           15    9605
NP_542392                                                              15    9605
NP_003813                                                              15    9605
NP_995582                                                              15    9605
NP_001263393                                                           15    9605
XP_006719734                                                           15    9605
XP_005245119                                                           15    9605
XP_005245118                                                           15    9605

>NP_115803
          Length = 1156

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKVMVNYMY 9
           SKVM NYMY
Sbjct: 507 SKVMANYMY 515



>NP_001275962
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VMVNYMY 9
           V+VNY+Y
Sbjct: 208 VLVNYIY 214



>NP_001275961
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VMVNYMY 9
           V+VNY+Y
Sbjct: 245 VLVNYIY 251



>NP_006206
          Length = 427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VMVNYMY 9
           V+VNY+Y
Sbjct: 208 VLVNYIY 214



>NP_056142
          Length = 1016

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KVMVNYMY 9
           +++VN+MY
Sbjct: 286 RLLVNFMY 293



>XP_006711311
          Length = 950

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KVMVNYMY 9
           +++VN+MY
Sbjct: 220 RLLVNFMY 227



>XP_005245106
          Length = 970

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   KVMVNYMY 9
           +++VN+MY
Sbjct: 286 RLLVNFMY 293



>NP_112503
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 354 KVMENFIY 361



>NP_000094
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 354 KVMENFIY 361



>NP_000615
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VMVNYMY 9
           +MVNY++
Sbjct: 198 IMVNYIF 204



>NP_000809
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SKVMVNYMY 9
          SKV VNY +
Sbjct: 83 SKVDVNYAF 91



>XP_006720469
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 252 KVMENFIY 259



>XP_005254249
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 295 KVMENFIY 302



>XP_005254248
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 354 KVMENFIY 361



>XP_005254247
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KVMVNYMY 9
           KVM N++Y
Sbjct: 354 KVMENFIY 361



>NP_001127838
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SKVMVNYMY 9
          SKV VNY +
Sbjct: 83 SKVDVNYAF 91



>NP_001273886
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKVMVNYM 8
           +KVMV+Y+
Sbjct: 249 TKVMVDYI 256



>NP_149115
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKVMVNYM 8
           +KVMV+Y+
Sbjct: 392 TKVMVDYI 399



>NP_001207423
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKVMVNYM 8
           ++VMV YM
Sbjct: 245 ARVMVRYM 252



>NP_001207425
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKVMVNYM 8
           ++VMV YM
Sbjct: 245 ARVMVRYM 252



>NP_542392
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKVMVNYM 8
           ++VMV YM
Sbjct: 276 ARVMVRYM 283



>NP_003813
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  MVNYMY 9
          MVNY Y
Sbjct: 27 MVNYSY 32



>NP_995582
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  MVNYMY 9
          MVNY Y
Sbjct: 73 MVNYSY 78



>NP_001263393
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4 MVNYMY 9
         MVNY Y
Sbjct: 1 MVNYSY 6



>XP_006719734
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SKVMVNYM 8
           +KVMV+Y+
Sbjct: 319 TKVMVDYI 326



>XP_005245119
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4 MVNYMY 9
         MVNY Y
Sbjct: 1 MVNYSY 6



>XP_005245118
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   MVNYMY 9
           MVNY Y
Sbjct: 97  MVNYSY 102



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.129    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 343,455
Number of extensions: 384
Number of successful extensions: 27
Number of sequences better than 10000.0: 27
Number of HSP's gapped: 27
Number of HSP's successfully gapped: 27
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)