Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002040                                                              20     390
NP_115810                                                              17    3301
NP_705895                                                              16    5631
NP_002137                                                              16    5631
XP_005257339                                                           16    5631
XP_005257337                                                           16    5631
XP_006721918                                                           16    5631
XP_005257334                                                           16    5631
XP_006721917                                                           16    5631
XP_005249789                                                           16    5631
XP_005249788                                                           16    5631
XP_006715778                                                           16    5631
XP_005249787                                                           16    5631
NP_109377                                                              16    5631
NP_004501                                                              16    7355
NP_004500                                                              16    7355
NP_001103691                                                           16    7355
NP_001103690                                                           16    7355
NP_536349                                                              16    7355
NP_006774                                                              16    7355
NP_001103689                                                           16    7355
NP_001171944                                                           16    7355
NP_001273282                                                           16    7355
NP_001273281                                                           16    7355
NP_064575                                                              16    7355
XP_006722922                                                           16    7355
XP_005246584                                                           16    7355
XP_006712552                                                           16    7355
XP_006712550                                                           16    7355
XP_006712549                                                           16    7355
XP_005246582                                                           16    7355
XP_006710841                                                           16    7355
XP_005276104                                                           16    7355
NP_060316                                                              15    9605
NP_055951                                                              15    9605
NP_001229263                                                           15    9605
NP_055183                                                              15    9605
NP_954629                                                              15    9605
NP_001229262                                                           15    9605
NP_001229264                                                           15    9605
NP_001001933                                                           15    9605
NP_689602                                                              15    9605
NP_001269736                                                           15    9605
NP_001269735                                                           15    9605
NP_001269734                                                           15    9605
NP_062547                                                              15    9605
NP_001243043                                                           15    9605
NP_073737                                                              15    9605
XP_006718823                                                           15    9605
XP_005251972                                                           15    9605
XP_005265032                                                           15    9605
XP_005265031                                                           15    9605
XP_005265030                                                           15    9605
XP_005246831                                                           15    9605
XP_005246830                                                           15    9605
>NP_002040
          Length = 413

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKRARTQCT 9
           SKRA TQCT
Sbjct: 251 SKRAGTQCT 259
>NP_115810
          Length = 567

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SKRARTQCT 9
          +K +RTQC+
Sbjct: 28 AKNSRTQCS 36
>NP_705895
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>NP_002137
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 188 SKRARTAYT 196
>XP_005257339
          Length = 299

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SKRARTQCT 9
          SKRART  T
Sbjct: 56 SKRARTAYT 64
>XP_005257337
          Length = 358

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 115 SKRARTAYT 123
>XP_006721918
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 188 SKRARTAYT 196
>XP_005257334
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 188 SKRARTAYT 196
>XP_006721917
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 188 SKRARTAYT 196
>XP_005249789
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>XP_005249788
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>XP_006715778
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>XP_005249787
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>NP_109377
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           SKRART  T
Sbjct: 191 SKRARTAYT 199
>NP_004501
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 335 AQKARTEC 342
>NP_004500
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 335 AQKARTEC 342
>NP_001103691
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKRARTQ 7
           SKRA+TQ
Sbjct: 222 SKRAQTQ 228
>NP_001103690
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKRARTQ 7
           SKRA+TQ
Sbjct: 222 SKRAQTQ 228
>NP_536349
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 335 AQKARTEC 342
>NP_006774
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKRARTQ 7
           SKRA+TQ
Sbjct: 222 SKRAQTQ 228
>NP_001103689
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKRARTQ 7
           SKRA+TQ
Sbjct: 222 SKRAQTQ 228
>NP_001171944
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 341 AQKARTEC 348
>NP_001273282
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           + RAR QC+
Sbjct: 279 ASRARIQCS 287
>NP_001273281
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           + RAR QC+
Sbjct: 320 ASRARIQCS 328
>NP_064575
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           + RAR QC+
Sbjct: 340 ASRARIQCS 348
>XP_006722922
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RARTQC 8
           RART+C
Sbjct: 474 RARTRC 479
>XP_005246584
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 132 AQKARTEC 139
>XP_006712552
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 341 AQKARTEC 348
>XP_006712550
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 341 AQKARTEC 348
>XP_006712549
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 335 AQKARTEC 342
>XP_005246582
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SKRARTQC 8
           +++ART+C
Sbjct: 341 AQKARTEC 348
>XP_006710841
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           + RAR QC+
Sbjct: 279 ASRARIQCS 287
>XP_005276104
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SKRARTQC 8
           ++RAR QC
Sbjct: 171 NRRARHQC 178
>NP_060316
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRARTQC 8
           KRA T+C
Sbjct: 151 KRALTEC 157
>NP_055951
          Length = 2570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SKRARTQCT 9
            S RAR  CT
Sbjct: 2129 SCRARNPCT 2137
>NP_001229263
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 219 AKRARTSFT 227
>NP_055183
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 248 AKRARTSFT 256
>NP_954629
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 248 AKRARTSFT 256
>NP_001229262
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 237 AKRARTSFT 245
>NP_001229264
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SKRARTQCT 9
          +KRART  T
Sbjct: 32 AKRARTSFT 40
>NP_001001933
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 225 AKRARTSFT 233
>NP_689602
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KRARTQC 8
           K +RTQC
Sbjct: 120 KGSRTQC 126
>NP_001269736
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 51 SKRPKLSCT 59
>NP_001269735
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 89 SKRPKLSCT 97
>NP_001269734
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 89 SKRPKLSCT 97
>NP_062547
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   ARTQC 8
           ARTQC
Sbjct: 289 ARTQC 293
>NP_001243043
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 215 AKRARTSFT 223
>NP_073737
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 89 SKRPKLSCT 97
>XP_006718823
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   RARTQC 8
           RART C
Sbjct: 154 RARTHC 159
>XP_005251972
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKRARTQCT 9
           +KRART  T
Sbjct: 224 AKRARTSFT 232
>XP_005265032
          Length = 2545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SKRARTQCT 9
            S RAR  CT
Sbjct: 2079 SCRARNPCT 2087
>XP_005265031
          Length = 2569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SKRARTQCT 9
            S RAR  CT
Sbjct: 2129 SCRARNPCT 2137
>XP_005265030
          Length = 2595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    SKRARTQCT 9
            S RAR  CT
Sbjct: 2129 SCRARNPCT 2137
>XP_005246831
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 89 SKRPKLSCT 97
>XP_005246830
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  SKRARTQCT 9
          SKR +  CT
Sbjct: 89 SKRPKLSCT 97
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.112    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 459,977
Number of extensions: 720
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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