Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           18    1135
NP_036462                                                              18    1135
NP_001243397                                                           18    1135
XP_005269721                                                           18    1135
NP_001094891                                                           16    5631
NP_620636                                                              16    7355
NP_001607                                                              16    7355
NP_003062                                                              16    7355
NP_060275                                                              16    7355
NP_001265509                                                           16    7355
NP_001265508                                                           16    7355
NP_006276                                                              16    7355
XP_005259081                                                           16    7355
XP_006723314                                                           16    7355
XP_005259080                                                           16    7355
XP_006723313                                                           16    7355
XP_005247781                                                           16    7355
XP_005263900                                                           16    7355
NP_112224                                                              15    9605
NP_001157755                                                           15    9605
NP_006763                                                              15    9605
NP_679211                                                              15    9605
NP_001157753                                                           15    9605
NP_659469                                                              15    9605
NP_001104508                                                           15    9605
NP_001274079                                                           15    9605
NP_001097                                                              15    9605
XP_005253212                                                           15    9605
XP_005253211                                                           15    9605
XP_005250270                                                           15    9605
XP_005250269                                                           15    9605
XP_005250266                                                           15    9605
XP_006715960                                                           15    9605
XP_005250265                                                           15    9605
XP_005250264                                                           15    9605
XP_005250262                                                           15    9605
XP_006715382                                                           15    9605
XP_005265640                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKNILLR S
Sbjct: 468 SKNILLRHS 476
>NP_036462
          Length = 2073

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKNILLR S
Sbjct: 760 SKNILLRHS 768
>NP_001243397
          Length = 1890

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKNILLR S
Sbjct: 577 SKNILLRHS 585
>XP_005269721
          Length = 2073

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKNILLR S
Sbjct: 760 SKNILLRHS 768
>NP_001094891
          Length = 1022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKNILLR 7
           SKNI+LR
Sbjct: 537 SKNIILR 543
>NP_620636
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNILLRRS 9
           KNI LRR+
Sbjct: 638 KNITLRRT 645
>NP_001607
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKN+LL+ +
Sbjct: 325 SKNVLLKNN 333
>NP_003062
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNILLRRS 9
           KNI LRR+
Sbjct: 638 KNITLRRT 645
>NP_060275
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           S+N+ LRRS
Sbjct: 318 SENLSLRRS 326
>NP_001265509
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKN+LL+ +
Sbjct: 217 SKNVLLKNN 225
>NP_001265508
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKN+LL+ +
Sbjct: 325 SKNVLLKNN 333
>NP_006276
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKNILLRR 8
           SKN L+RR
Sbjct: 178 SKNCLVRR 185
>XP_005259081
          Length = 966

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           S+N+ LRRS
Sbjct: 419 SENLSLRRS 427
>XP_006723314
          Length = 968

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           S+N+ LRRS
Sbjct: 419 SENLSLRRS 427
>XP_005259080
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           S+N+ LRRS
Sbjct: 419 SENLSLRRS 427
>XP_006723313
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           S+N+ LRRS
Sbjct: 419 SENLSLRRS 427
>XP_005247781
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KNILLRRS 9
           KNI LRR+
Sbjct: 637 KNITLRRT 644
>XP_005263900
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKNILLRRS 9
           SKN+LL+ +
Sbjct: 325 SKNVLLKNN 333
>NP_112224
          Length = 1849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKNILLRRS 9
           SKN LLR S
Sbjct: 764 SKNKLLRTS 772
>NP_001157755
          Length = 109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 81 KNILLR 86
>NP_006763
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SKNILLRRS 9
          S+N LLRR+
Sbjct: 77 SRNKLLRRT 85
>NP_679211
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 537 KNILLR 542
>NP_001157753
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 536 KNILLR 541
>NP_659469
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 72 KNILLR 77
>NP_001104508
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 72 KNILLR 77
>NP_001274079
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 72 KNILLR 77
>NP_001097
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKNILLR 7
           SKN+LL+
Sbjct: 324 SKNVLLK 330
>XP_005253212
          Length = 1838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKNILLRRS 9
           SKN LLR S
Sbjct: 721 SKNKLLRTS 729
>XP_005253211
          Length = 1881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SKNILLRRS 9
           SKN LLR S
Sbjct: 764 SKNKLLRTS 772
>XP_005250270
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 72 KNILLR 77
>XP_005250269
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 162 KNILLR 167
>XP_005250266
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 72 KNILLR 77
>XP_006715960
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 74 KNILLR 79
>XP_005250265
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 162 KNILLR 167
>XP_005250264
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 162 KNILLR 167
>XP_005250262
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KNILLR 7
           KNILLR
Sbjct: 162 KNILLR 167
>XP_006715382
          Length = 109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  KNILLR 7
          KNILLR
Sbjct: 81 KNILLR 86
>XP_005265640
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SKNILLR 7
           SKN+LL+
Sbjct: 345 SKNVLLK 351
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.133    0.318 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 448,569
Number of extensions: 721
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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