Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              19     869
NP_001087241                                                           19     869
XP_005265799                                                           19     869
XP_005265798                                                           19     869
XP_005265797                                                           19     869
NP_001258681                                                           18    1482
NP_001011544                                                           17    2528
NP_005357                                                              17    2528
NP_001275896                                                           17    2528
NP_001275894                                                           17    2528
NP_077817                                                              17    2528
NP_001275893                                                           17    2528
XP_005247863                                                           17    2528
NP_036604                                                              17    4312
NP_002358                                                              17    4312
NP_002355                                                              17    4312
NP_872312                                                              17    4312
XP_006716601                                                           17    4312
NP_055085                                                              16    5631
NP_001229965                                                           16    5631
NP_001119807                                                           16    5631
XP_006723055                                                           16    5631
XP_005258525                                                           16    5631
NP_056224                                                              16    7355
NP_001139681                                                           16    7355
NP_001230713                                                           16    7355
NP_001137311                                                           16    7355
NP_002590                                                              16    7355
NP_619648                                                              16    7355
XP_005274097                                                           16    7355
XP_006714236                                                           16    7355
XP_006714235                                                           16    7355
NP_071745                                                              16    7355
NP_001123612                                                           16    7355
NP_000397                                                              15    9605
NP_001012781                                                           15    9605
NP_001093391                                                           15    9605
NP_573403                                                              15    9605
NP_775970                                                              15    9605
NP_001264236                                                           15    9605
NP_001073880                                                           15    9605
NP_001005333                                                           15    9605
NP_877496                                                              15    9605
NP_001005332                                                           15    9605
NP_619649                                                              15    9605
XP_005260559                                                           15    9605
XP_005260558                                                           15    9605
XP_006723918                                                           15    9605
XP_005260557                                                           15    9605
XP_005260556                                                           15    9605
XP_005260555                                                           15    9605
XP_005260554                                                           15    9605
XP_006723917                                                           15    9605
XP_005260553                                                           15    9605
XP_006722724                                                           15    9605
XP_005259839                                                           15    9605
XP_006722723                                                           15    9605
XP_006722722                                                           15    9605
NP_008917                                                              15    9605
>NP_000213
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKLKVLSYL 9
           S+LKVLSYL
Sbjct: 639 SELKVLSYL 647
>NP_001087241
          Length = 972

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKLKVLSYL 9
           S+LKVLSYL
Sbjct: 635 SELKVLSYL 643
>XP_005265799
          Length = 973

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKLKVLSYL 9
           S+LKVLSYL
Sbjct: 636 SELKVLSYL 644
>XP_005265798
          Length = 976

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKLKVLSYL 9
           S+LKVLSYL
Sbjct: 640 SELKVLSYL 648
>XP_005265797
          Length = 977

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SKLKVLSYL 9
           S+LKVLSYL
Sbjct: 640 SELKVLSYL 648
>NP_001258681
          Length = 275

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL YL
Sbjct: 213 SKMKVLEYL 221
>NP_001011544
          Length = 400

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL Y+
Sbjct: 366 SKMKVLEYI 374
>NP_005357
          Length = 429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL Y+
Sbjct: 395 SKMKVLEYI 403
>NP_001275896
          Length = 445

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           KLKVLSY
Sbjct: 439 KLKVLSY 445
>NP_001275894
          Length = 577

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           KLKVLSY
Sbjct: 571 KLKVLSY 577
>NP_077817
          Length = 597

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           KLKVLSY
Sbjct: 591 KLKVLSY 597
>NP_001275893
          Length = 579

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           KLKVLSY
Sbjct: 573 KLKVLSY 579
>XP_005247863
          Length = 597

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           KLKVLSY
Sbjct: 591 KLKVLSY 597
>NP_036604
          Length = 466

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SKLKVLSYL 9
          SKLK L YL
Sbjct: 63 SKLKKLEYL 71
>NP_002358
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL +L
Sbjct: 281 SKMKVLEFL 289
>NP_002355
          Length = 319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL +L
Sbjct: 284 SKMKVLEFL 292
>NP_872312
          Length = 347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL +L
Sbjct: 284 SKMKVLEFL 292
>XP_006716601
          Length = 469

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SKLKVLSYL 9
          SKLK L YL
Sbjct: 66 SKLKKLEYL 74
>NP_055085
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKVLSYL 9
           LKVLSY+
Sbjct: 338 LKVLSYI 344
>NP_001229965
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKVLSYL 9
           LKVLSY+
Sbjct: 338 LKVLSYI 344
>NP_001119807
          Length = 487

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKVLSYL 9
           LKVLSY+
Sbjct: 338 LKVLSYI 344
>XP_006723055
          Length = 260

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKVLSYL 9
           LKVLSY+
Sbjct: 111 LKVLSYI 117
>XP_005258525
          Length = 278

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKVLSYL 9
           LKVLSY+
Sbjct: 129 LKVLSYI 135
>NP_056224
          Length = 3123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    LKVLSYL 9
            LK+LSY+
Sbjct: 1130 LKILSYI 1136
>NP_001139681
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           +LKVL YL
Sbjct: 237 QLKVLQYL 244
>NP_001230713
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           +LKVL YL
Sbjct: 225 QLKVLQYL 232
>NP_001137311
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           +LKVL YL
Sbjct: 239 QLKVLQYL 246
>NP_002590
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           +LKVL YL
Sbjct: 246 QLKVLQYL 253
>NP_619648
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           K+KVL Y+
Sbjct: 477 KMKVLEYM 484
>XP_005274097
          Length = 940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLKVLSYL 9
           +LKVL YL
Sbjct: 245 QLKVLQYL 252
>XP_006714236
          Length = 771

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           S LKV+S+L
Sbjct: 747 SDLKVISFL 755
>XP_006714235
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           S LKV+S+L
Sbjct: 817 SDLKVISFL 825
>NP_071745
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           +LKVLSY
Sbjct: 136 ELKVLSY 142
>NP_001123612
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KLKVLSY 8
           +LKVLSY
Sbjct: 136 ELKVLSY 142
>NP_000397
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 115 KVLSYL 120
>NP_001012781
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 115 KVLSYL 120
>NP_001093391
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 286 SKMKVLEFV 294
>NP_573403
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 497 SKLRSLSY 504
>NP_775970
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 280 SKMKVLEFV 288
>NP_001264236
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 282 SKMKVLEFV 290
>NP_001073880
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 345 KVLSYL 350
>NP_001005333
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 699 SKMKVLRFI 707
>NP_877496
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 497 SKLRSLSY 504
>NP_001005332
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 643 SKMKVLRFI 651
>NP_619649
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 259 SKMKVLKFV 267
>XP_005260559
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 314 SKLRSLSY 321
>XP_005260558
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 314 SKLRSLSY 321
>XP_006723918
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 409 SKLRSLSY 416
>XP_005260557
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 409 SKLRSLSY 416
>XP_005260556
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 409 SKLRSLSY 416
>XP_005260555
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 409 SKLRSLSY 416
>XP_005260554
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 409 SKLRSLSY 416
>XP_006723917
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 497 SKLRSLSY 504
>XP_005260553
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SKLKVLSY 8
           SKL+ LSY
Sbjct: 497 SKLRSLSY 504
>XP_006722724
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 310 KVLSYL 315
>XP_005259839
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 310 KVLSYL 315
>XP_006722723
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 344 KVLSYL 349
>XP_006722722
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KVLSYL 9
           KVLSYL
Sbjct: 356 KVLSYL 361
>NP_008917
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SKLKVLSYL 9
           SK+KVL ++
Sbjct: 643 SKMKVLRFI 651
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.133    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 396,766
Number of extensions: 591
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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