Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1135
NP_653080                                                              18    1135
XP_005267292                                                           18    1135
XP_005267291                                                           18    1135
XP_005267290                                                           18    1135
NP_001191676                                                           17    2528
NP_002904                                                              17    2528
NP_003591                                                              17    3301
NP_940838                                                              17    3301
NP_940837                                                              17    3301
NP_940839                                                              17    3301
NP_940835                                                              17    3301
NP_940836                                                              17    3301
XP_006723935                                                           17    3301
XP_005260591                                                           17    3301
XP_006723934                                                           17    3301
NP_078997                                                              17    4312
NP_001132931                                                           16    7355
NP_689822                                                              16    7355
NP_775969                                                              16    7355
NP_036616                                                              16    7355
NP_001164582                                                           16    7355
NP_001164581                                                           16    7355
NP_001164580                                                           16    7355
NP_005925                                                              16    7355
NP_001269736                                                           16    7355
NP_001269735                                                           16    7355
NP_001269734                                                           16    7355
NP_060184                                                              16    7355
NP_073737                                                              16    7355
XP_006724704                                                           16    7355
XP_005259618                                                           16    7355
XP_005246831                                                           16    7355
XP_005246830                                                           16    7355
XP_005273140                                                           16    7355
XP_006711814                                                           16    7355
XP_005273139                                                           16    7355
XP_005273138                                                           16    7355
NP_001120965                                                           15    9605
NP_066187                                                              15    9605
NP_001139                                                              15    9605
NP_079410                                                              15    9605
NP_009187                                                              15    9605
NP_055836                                                              15    9605
XP_005256233                                                           15    9605
XP_005256232                                                           15    9605
XP_005256231                                                           15    9605
XP_005256229                                                           15    9605
XP_005256228                                                           15    9605
XP_005256227                                                           15    9605
XP_006721346                                                           15    9605
XP_005256226                                                           15    9605
XP_006721345                                                           15    9605
XP_006721344                                                           15    9605
XP_006721343                                                           15    9605
XP_005256225                                                           15    9605
XP_006718490                                                           15    9605
XP_005248755                                                           15    9605
XP_005248754                                                           15    9605
XP_006714257                                                           15    9605
XP_006714256                                                           15    9605
XP_005263005                                                           15    9605
XP_006714254                                                           15    9605
XP_005263002                                                           15    9605
XP_005262999                                                           15    9605
XP_006714252                                                           15    9605
XP_006714251                                                           15    9605
XP_006714250                                                           15    9605
NP_001138684                                                           15    9605
NP_001138683                                                           15    9605
NP_001139113                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           SKESE KQS
Sbjct: 227 SKESEPKQS 235
>NP_653080
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           SKESE KQS
Sbjct: 129 SKESEPKQS 137
>XP_005267292
          Length = 1677

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           SKESE KQS
Sbjct: 122 SKESEPKQS 130
>XP_005267291
          Length = 1684

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           SKESE KQS
Sbjct: 129 SKESEPKQS 137
>XP_005267290
          Length = 1782

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           SKESE KQS
Sbjct: 227 SKESEPKQS 235
>NP_001191676
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   KESESKQS 9
           KESESK+S
Sbjct: 522 KESESKKS 529
>NP_002904
          Length = 1147

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   KESESKQS 9
           KESESK+S
Sbjct: 522 KESESKKS 529
>NP_003591
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>NP_940838
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>NP_940837
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>NP_940839
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>NP_940835
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>NP_940836
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>XP_006723935
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>XP_005260591
          Length = 403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 395 NKESASKQS 403
>XP_006723934
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           +KES SKQS
Sbjct: 411 NKESASKQS 419
>NP_078997
          Length = 3616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SKESESKQS 9
            +KESE KQ+
Sbjct: 3186 NKESEKKQT 3194
>NP_001132931
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 309 TKESESK 315
>NP_689822
          Length = 725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 309 TKESESK 315
>NP_775969
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESESKQS 9
           ESESK+S
Sbjct: 150 ESESKES 156
>NP_036616
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KESESKQS 9
          K SESK+S
Sbjct: 70 KSSESKES 77
>NP_001164582
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESESKQS 9
           ESESK+S
Sbjct: 150 ESESKES 156
>NP_001164581
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESESKQS 9
           ESESK+S
Sbjct: 150 ESESKES 156
>NP_001164580
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESESKQS 9
           ESESK+S
Sbjct: 150 ESESKES 156
>NP_005925
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+SESK S
Sbjct: 207 KDSESKSS 214
>NP_001269736
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 190 SRESESSRS 198
>NP_001269735
          Length = 635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 172 SRESESSRS 180
>NP_001269734
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 228 SRESESSRS 236
>NP_060184
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SKESESKQS 9
          +KE E+KQS
Sbjct: 27 AKELETKQS 35
>NP_073737
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 228 SRESESSRS 236
>XP_006724704
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESESKQS 9
           ESESK+S
Sbjct: 150 ESESKES 156
>XP_005259618
          Length = 517

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+SESK S
Sbjct: 165 KDSESKSS 172
>XP_005246831
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 228 SRESESSRS 236
>XP_005246830
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SKESESKQS 9
           S+ESES +S
Sbjct: 228 SRESESSRS 236
>XP_005273140
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 144 TKESESK 150
>XP_006711814
          Length = 603

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 187 TKESESK 193
>XP_005273139
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 350 TKESESK 356
>XP_005273138
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SKESESK 7
           +KESESK
Sbjct: 365 TKESESK 371
>NP_001120965
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1447 TKESESDQ 1454
>NP_066187
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1456 TKESESDQ 1463
>NP_001139
          Length = 3957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1456 TKESESDQ 1463
>NP_079410
          Length = 2881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>NP_009187
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+S SKQS
Sbjct: 326 KDSPSKQS 333
>NP_055836
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SKESESKQS 9
            S+E+E+KQ+
Sbjct: 2160 SEETETKQT 2168
>XP_005256233
          Length = 2391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  ESESKQ 8
          ESESKQ
Sbjct: 11 ESESKQ 16
>XP_005256232
          Length = 2424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  ESESKQ 8
          ESESKQ
Sbjct: 44 ESESKQ 49
>XP_005256231
          Length = 2573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_005256229
          Length = 2881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_005256228
          Length = 2882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_005256227
          Length = 2897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_006721346
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_005256226
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_006721345
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_006721344
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_006721343
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_005256225
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ESESKQ 8
           ESESKQ
Sbjct: 518 ESESKQ 523
>XP_006718490
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+S SKQS
Sbjct: 326 KDSPSKQS 333
>XP_005248755
          Length = 2465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SKESESKQS 9
            S+E+E+KQ+
Sbjct: 1902 SEETETKQT 1910
>XP_005248754
          Length = 2583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SKESESKQS 9
            S+E+E+KQ+
Sbjct: 2020 SEETETKQT 2028
>XP_006714257
          Length = 4145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1465 TKESESDQ 1472
>XP_006714256
          Length = 1901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1485 TKESESDQ 1492
>XP_005263005
          Length = 2019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1455 TKESESDQ 1462
>XP_006714254
          Length = 2049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1485 TKESESDQ 1492
>XP_005263002
          Length = 4072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1423 TKESESDQ 1430
>XP_005262999
          Length = 4147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1467 TKESESDQ 1474
>XP_006714252
          Length = 4153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1473 TKESESDQ 1480
>XP_006714251
          Length = 4165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1485 TKESESDQ 1492
>XP_006714250
          Length = 4190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SKESESKQ 8
            +KESES Q
Sbjct: 1510 TKESESDQ 1517
>NP_001138684
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+S SKQS
Sbjct: 182 KDSPSKQS 189
>NP_001138683
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KESESKQS 9
           K+S SKQS
Sbjct: 304 KDSPSKQS 311
>NP_001139113
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SKESESKQS 9
           SKE E +QS
Sbjct: 576 SKERERRQS 584
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.246   0.0747    0.142 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 472,969
Number of extensions: 975
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 20 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (13.7 bits)
S2: 28 (15.4 bits)

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