Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_001035706                                                           18    1935
XP_005255000                                                           18    1935
XP_005254998                                                           18    1935
NP_689914                                                              17    3301
NP_001123887                                                           17    3301
NP_110444                                                              17    3301
NP_776186                                                              17    4312
XP_006715947                                                           17    4312
XP_006713658                                                           17    4312
NP_056110                                                              16    5631
NP_001182612                                                           16    5631
NP_003234                                                              16    5631
NP_001182613                                                           16    5631
NP_004237                                                              16    5631
XP_005258159                                                           16    5631
XP_006722384                                                           16    5631
XP_005256918                                                           16    5631
XP_006710931                                                           16    5631
XP_006710930                                                           16    5631
NP_031386                                                              16    7355
NP_001186734                                                           16    7355
NP_001185739                                                           16    7355
NP_003618                                                              16    7355
XP_005274415                                                           16    7355
XP_005274414                                                           16    7355
NP_005281                                                              15    9605
NP_001185471                                                           15    9605
NP_001185472                                                           15    9605
NP_060028                                                              15    9605
NP_001257903                                                           15    9605
NP_997191                                                              15    9605
NP_689856                                                              15    9605
NP_001152956                                                           15    9605
NP_009121                                                              15    9605
NP_085053                                                              15    9605
NP_002799                                                              15    9605
NP_001265637                                                           15    9605
NP_001265638                                                           15    9605
XP_006722188                                                           15    9605
XP_005257762                                                           15    9605
XP_006722187                                                           15    9605
XP_005257760                                                           15    9605
XP_005257761                                                           15    9605
XP_006721269                                                           15    9605
XP_005269527                                                           15    9605
XP_005269526                                                           15    9605
XP_005265933                                                           15    9605
XP_006711682                                                           15    9605
NP_001020404                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   IVFYNSVF 9
           IVFYNSVF
Sbjct: 753 IVFYNSVF 760
>NP_001035706
          Length = 757

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VFYNSVF 9
           VFYNS+F
Sbjct: 226 VFYNSLF 232
>XP_005255000
          Length = 721

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VFYNSVF 9
           VFYNS+F
Sbjct: 226 VFYNSLF 232
>XP_005254998
          Length = 757

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VFYNSVF 9
           VFYNS+F
Sbjct: 226 VFYNSLF 232
>NP_689914
          Length = 5058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIVFYNSVF 9
            SI+F NS+F
Sbjct: 3461 SIIFSNSLF 3469
>NP_001123887
          Length = 279

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SIVFYNSVF 9
           SI  YNSV+
Sbjct: 191 SIALYNSVY 199
>NP_110444
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SIVFYNSVF 9
           SI  YNSV+
Sbjct: 160 SIALYNSVY 168
>NP_776186
          Length = 236

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VFYNSV 8
          VFYNSV
Sbjct: 83 VFYNSV 88
>XP_006715947
          Length = 738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIVFYNSVF 9
          S +F+N+VF
Sbjct: 22 STIFHNTVF 30
>XP_006713658
          Length = 212

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VFYNSV 8
          VFYNSV
Sbjct: 83 VFYNSV 88
>NP_056110
          Length = 2005

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIVFYNSVF 9
            SIV Y S+F
Sbjct: 1636 SIVMYKSLF 1644
>NP_001182612
          Length = 850

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IVFYNSV 8
           +V+YNS+
Sbjct: 516 VVYYNSI 522
>NP_003234
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IVFYNSV 8
           +V+YNS+
Sbjct: 517 VVYYNSI 523
>NP_001182613
          Length = 850

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IVFYNSV 8
           +V+YNS+
Sbjct: 516 VVYYNSI 522
>NP_004237
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVFYNS 7
           +VFYNS
Sbjct: 233 VVFYNS 238
>XP_005258159
          Length = 1817

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIVFYNSVF 9
            SIV Y S+F
Sbjct: 1448 SIVMYKSLF 1456
>XP_006722384
          Length = 1877

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIVFYNSVF 9
            SIV Y S+F
Sbjct: 1508 SIVMYKSLF 1516
>XP_005256918
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  IVFYNS 7
          +VFYNS
Sbjct: 80 VVFYNS 85
>XP_006710931
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IVFYNSV 8
           +V+YNS+
Sbjct: 517 VVYYNSI 523
>XP_006710930
          Length = 851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   IVFYNSV 8
           +V+YNS+
Sbjct: 517 VVYYNSI 523
>NP_031386
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SIVFYNSVF 9
          S VF NS+F
Sbjct: 75 SAVFLNSLF 83
>NP_001186734
          Length = 216

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SIVFYNSVF 9
          S VF NS+F
Sbjct: 75 SAVFLNSLF 83
>NP_001185739
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           ++ FY+SVF
Sbjct: 351 TVGFYSSVF 359
>NP_003618
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           ++ FY+SVF
Sbjct: 351 TVGFYSSVF 359
>XP_005274415
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           ++ FY+SVF
Sbjct: 367 TVGFYSSVF 375
>XP_005274414
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           ++ FY+SVF
Sbjct: 377 TVGFYSSVF 385
>NP_005281
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VFYNSVF 9
          VFY +VF
Sbjct: 38 VFYTAVF 44
>NP_001185471
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           S +F+N+VF
Sbjct: 423 SKLFFNNVF 431
>NP_001185472
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           S +F+N+VF
Sbjct: 413 SKLFFNNVF 421
>NP_060028
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           S +F+N+VF
Sbjct: 396 SKLFFNNVF 404
>NP_001257903
          Length = 5121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           S +F+N+VF
Sbjct: 396 SKLFFNNVF 404
>NP_997191
          Length = 1888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIVFYNSV 8
            ++ FYNS+
Sbjct: 1409 TVQFYNSI 1416
>NP_689856
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    SIVFYN 6
            S++FYN
Sbjct: 1231 SLIFYN 1236
>NP_001152956
          Length = 1736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIVFYNSV 8
            ++ FYNS+
Sbjct: 1409 TVQFYNSI 1416
>NP_009121
          Length = 1000

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVFYNS 7
           I+FYNS
Sbjct: 539 ILFYNS 544
>NP_085053
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>NP_002799
          Length = 908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VFYNSVF 9
           V YNS+F
Sbjct: 721 VSYNSIF 727
>NP_001265637
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VFYNSVF 9
           V YNS+F
Sbjct: 591 VSYNSIF 597
>NP_001265638
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VFYNSVF 9
           V YNS+F
Sbjct: 562 VSYNSIF 568
>XP_006722188
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>XP_005257762
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>XP_006722187
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>XP_005257760
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>XP_005257761
          Length = 127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          ++F+NS F
Sbjct: 58 LIFHNSCF 65
>XP_006721269
          Length = 5138

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SIVFYNSVF 9
           S +F+N+VF
Sbjct: 413 SKLFFNNVF 421
>XP_005269527
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVFYNS 7
           I+FYNS
Sbjct: 492 ILFYNS 497
>XP_005269526
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   IVFYNS 7
           I+FYNS
Sbjct: 539 ILFYNS 544
>XP_005265933
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SIVFYNSVF 9
          +IVF+ SVF
Sbjct: 25 NIVFWFSVF 33
>XP_006711682
          Length = 1739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIVFYNSV 8
            ++ FYNS+
Sbjct: 1260 TVQFYNSI 1267
>NP_001020404
          Length = 121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IVFYNSVF 9
          I+FY S+F
Sbjct: 67 ILFYISIF 74
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.147    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 459,393
Number of extensions: 738
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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