Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              19     665
XP_005248577                                                           19     665
XP_005248576                                                           19     665
NP_001006620                                                           17    3301
NP_001077058                                                           16    5631
NP_001942                                                              16    5631
NP_001077057                                                           16    5631
XP_006716497                                                           16    5631
NP_001164604                                                           16    7355
NP_068578                                                              16    7355
NP_001269240                                                           16    7355
NP_001164603                                                           16    7355
NP_001269241                                                           16    7355
NP_974197                                                              16    7355
NP_974198                                                              16    7355
NP_005707                                                              16    7355
NP_974199                                                              16    7355
NP_974223                                                              16    7355
XP_006724897                                                           16    7355
XP_006724895                                                           16    7355
XP_005274773                                                           16    7355
XP_005274771                                                           16    7355
XP_006724894                                                           16    7355
XP_006716762                                                           16    7355
XP_006716761                                                           16    7355
XP_006716760                                                           16    7355
XP_006716759                                                           16    7355
XP_006716757                                                           16    7355
XP_005251165                                                           16    7355
XP_005251164                                                           16    7355
XP_005251163                                                           16    7355
XP_006716755                                                           16    7355
XP_006716754                                                           16    7355
XP_006716753                                                           16    7355
NP_663306                                                              15    9605
NP_003179                                                              15    9605
NP_663304                                                              15    9605
NP_663305                                                              15    9605
NP_006558                                                              15    9605
XP_005248868                                                           15    9605
XP_005248869                                                           15    9605
>NP_005912
          Length = 1512

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SISGDMVEA 9
           SISGD+VEA
Sbjct: 626 SISGDVVEA 634
>XP_005248577
          Length = 1349

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SISGDMVEA 9
           SISGD+VEA
Sbjct: 463 SISGDVVEA 471
>XP_005248576
          Length = 1375

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SISGDMVEA 9
           SISGD+VEA
Sbjct: 489 SISGDVVEA 497
>NP_001006620
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   SISGDMVE 8
           SISGD VE
Sbjct: 356 SISGDKVE 363
>NP_001077058
          Length = 185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SISGDMVE 8
           SISGD+++
Sbjct: 136 SISGDIID 143
>NP_001942
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SISGDMVE 8
           SISGD+++
Sbjct: 297 SISGDIID 304
>NP_001077057
          Length = 345

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SISGDMVE 8
           SISGD+++
Sbjct: 296 SISGDIID 303
>XP_006716497
          Length = 185

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SISGDMVE 8
           SISGD+++
Sbjct: 136 SISGDIID 143
>NP_001164604
          Length = 192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ISGDMVEA 9
          +SG+++EA
Sbjct: 75 VSGELIEA 82
>NP_068578
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 113 VSGELIEA 120
>NP_001269240
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 127 VSGELIEA 134
>NP_001164603
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 113 VSGELIEA 120
>NP_001269241
          Length = 230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 113 VSGELIEA 120
>NP_974197
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GDMVEA 9
           GDM+EA
Sbjct: 175 GDMIEA 180
>NP_974198
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GDMVEA 9
          GDM+EA
Sbjct: 78 GDMIEA 83
>NP_005707
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GDMVEA 9
           GDM+EA
Sbjct: 175 GDMIEA 180
>NP_974199
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GDMVEA 9
           GDM+EA
Sbjct: 175 GDMIEA 180
>NP_974223
          Length = 236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  GDMVEA 9
          GDM+EA
Sbjct: 78 GDMIEA 83
>XP_006724897
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ISGDMVEA 9
          +SG+++EA
Sbjct: 80 VSGELIEA 87
>XP_006724895
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 121 VSGELIEA 128
>XP_005274773
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 127 VSGELIEA 134
>XP_005274771
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 134 VSGELIEA 141
>XP_006724894
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   ISGDMVEA 9
           +SG+++EA
Sbjct: 135 VSGELIEA 142
>XP_006716762
          Length = 1571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1276 SISGDM 1281
>XP_006716761
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SISGDM 6
          SISGDM
Sbjct: 18 SISGDM 23
>XP_006716760
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SISGDM 6
           SISGDM
Sbjct: 133 SISGDM 138
>XP_006716759
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SISGDM 6
           SISGDM
Sbjct: 149 SISGDM 154
>XP_006716757
          Length = 1356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1061 SISGDM 1066
>XP_005251165
          Length = 1532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1237 SISGDM 1242
>XP_005251164
          Length = 1552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1257 SISGDM 1262
>XP_005251163
          Length = 1574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1279 SISGDM 1284
>XP_006716755
          Length = 1634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1339 SISGDM 1344
>XP_006716754
          Length = 1655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1360 SISGDM 1365
>XP_006716753
          Length = 1656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SISGDM 6
            SISGDM
Sbjct: 1361 SISGDM 1366
>NP_663306
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SISGDMVEA 9
          S +G+M+EA
Sbjct: 13 SSAGEMIEA 21
>NP_003179
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SISGDMVEA 9
          S +G+M+EA
Sbjct: 13 SSAGEMIEA 21
>NP_663304
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SISGDMVEA 9
          S +G+M+EA
Sbjct: 13 SSAGEMIEA 21
>NP_663305
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SISGDMVEA 9
          S +G+M+EA
Sbjct: 13 SSAGEMIEA 21
>NP_006558
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SISGDMVE 8
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
>XP_005248868
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SISGDMVE 8
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
>XP_005248869
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SISGDMVE 8
           +I GD+VE
Sbjct: 387 TIGGDLVE 394
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.120    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,074
Number of extensions: 573
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package