Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003290                                                              18    1935
NP_001276052                                                           17    4312
NP_006078                                                              17    4312
NP_821133                                                              17    4312
NP_001276058                                                           17    4312
NP_001276060                                                           17    4312
NP_001276059                                                           17    4312
NP_001276056                                                           17    4312
NP_817124                                                              17    4312
NP_073731                                                              17    4312
NP_476436                                                              17    4312
NP_476437                                                              17    4312
NP_006079                                                              17    4312
NP_036434                                                              16    5631
NP_061897                                                              16    5631
NP_056051                                                              16    5631
XP_006714219                                                           16    5631
XP_006714218                                                           16    5631
XP_006714217                                                           16    5631
XP_006714216                                                           16    5631
XP_005264436                                                           16    5631
XP_006712098                                                           16    5631
XP_006712097                                                           16    5631
XP_005270731                                                           16    5631
XP_005270730                                                           16    5631
XP_006710560                                                           16    5631
XP_006710559                                                           16    5631
XP_006710558                                                           16    5631
XP_006710557                                                           16    5631
XP_006710556                                                           16    5631
XP_006710555                                                           16    5631
XP_005270727                                                           16    5631
XP_006710554                                                           16    5631
XP_005270725                                                           16    5631
XP_005270724                                                           16    5631
XP_006710553                                                           16    5631
XP_005270723                                                           16    5631
XP_006710552                                                           16    5631
XP_006710551                                                           16    5631
XP_006710550                                                           16    5631
XP_006710549                                                           16    5631
XP_006710548                                                           16    5631
NP_757386                                                              16    7355
NP_054828                                                              16    7355
NP_055736                                                              16    7355
NP_001008701                                                           16    7355
XP_005260059                                                           16    7355
XP_005259876                                                           16    7355
XP_006722752                                                           16    7355
XP_005259875                                                           16    7355
XP_006722751                                                           16    7355
NP_821080                                                              15    9605
NP_878918                                                              15    9605
NP_055995                                                              15    9605
NP_006601                                                              15    9605
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_596870                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001060                                                              15    9605
XP_006720147                                                           15    9605
XP_005267517                                                           15    9605
XP_005267516                                                           15    9605
XP_005267515                                                           15    9605
XP_005267514                                                           15    9605
XP_005267513                                                           15    9605
XP_005267512                                                           15    9605
XP_005267511                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_003290
          Length = 803

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIRKEAESS 9
           S RKEAESS
Sbjct: 544 SSRKEAESS 552
>NP_001276052
          Length = 495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 171 VRKEAES 177
>NP_006078
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 120 VRKEAES 126
>NP_821133
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 120 VRKEAES 126
>NP_001276058
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 120 VRKEAES 126
>NP_001276060
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRKEAES 8
          +RKEAES
Sbjct: 48 VRKEAES 54
>NP_001276059
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  IRKEAES 8
          +RKEAES
Sbjct: 48 VRKEAES 54
>NP_001276056
          Length = 489

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 165 VRKEAES 171
>NP_817124
          Length = 444

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 120 VRKEAES 126
>NP_073731
          Length = 504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           S+R+EAE+S
Sbjct: 159 SLRQEAENS 167
>NP_476436
          Length = 503

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           S+R+EAE+S
Sbjct: 159 SLRQEAENS 167
>NP_476437
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           S+R+EAE+S
Sbjct: 159 SLRQEAENS 167
>NP_006079
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKEAES
Sbjct: 120 VRKEAES 126
>NP_036434
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>NP_061897
          Length = 2071

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SIRKEAES 8
            +I+KEAES
Sbjct: 1435 NIKKEAES 1442
>NP_056051
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1181 TVRKQSESS 1189
>XP_006714219
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           ++RK++ESS
Sbjct: 747 TVRKQSESS 755
>XP_006714218
          Length = 846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           ++RK++ESS
Sbjct: 552 TVRKQSESS 560
>XP_006714217
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           ++RK++ESS
Sbjct: 725 TVRKQSESS 733
>XP_006714216
          Length = 1026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SIRKEAESS 9
           ++RK++ESS
Sbjct: 738 TVRKQSESS 746
>XP_005264436
          Length = 1881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SIRKEAES 8
            +I+KEAES
Sbjct: 1435 NIKKEAES 1442
>XP_006712098
          Length = 2059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SIRKEAES 8
            +I+KEAES
Sbjct: 1423 NIKKEAES 1430
>XP_006712097
          Length = 2070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SIRKEAES 8
            +I+KEAES
Sbjct: 1435 NIKKEAES 1442
>XP_005270731
          Length = 1177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_005270730
          Length = 1177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_006710560
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710559
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710558
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710557
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710556
          Length = 1195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710555
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_005270727
          Length = 1403

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_006710554
          Length = 1421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_005270725
          Length = 1446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_005270724
          Length = 1446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1130 TVRKQSESS 1138
>XP_006710553
          Length = 1451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1135 TVRKQSESS 1143
>XP_005270723
          Length = 1459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1143 TVRKQSESS 1151
>XP_006710552
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710551
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710550
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710549
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>XP_006710548
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    SIRKEAESS 9
            ++RK++ESS
Sbjct: 1148 TVRKQSESS 1156
>NP_757386
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           IRKEA+ S
Sbjct: 241 IRKEAQKS 248
>NP_054828
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SIRKEAESS 9
          S+RK+A++S
Sbjct: 76 SLRKDAQNS 84
>NP_055736
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1151 TVRKQTESS 1159
>NP_001008701
          Length = 1474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1156 TVRKQTESS 1164
>XP_005260059
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  IRKEAESS 9
          IRKEA+ S
Sbjct: 31 IRKEAQKS 38
>XP_005259876
          Length = 1498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1156 TVRKQTESS 1164
>XP_006722752
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1120 TVRKQTESS 1128
>XP_005259875
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1151 TVRKQTESS 1159
>XP_006722751
          Length = 1498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            ++RK+ ESS
Sbjct: 1156 TVRKQTESS 1164
>NP_821080
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKE+ES
Sbjct: 120 VRKESES 126
>NP_878918
          Length = 6907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>NP_055995
          Length = 6885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>NP_006601
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RKEAES 8
           RKEAES
Sbjct: 555 RKEAES 560
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_596870
          Length = 5604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_001060
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IRKEAES 8
           +RKE+ES
Sbjct: 120 VRKESES 126
>XP_006720147
          Length = 4788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267517
          Length = 6883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267516
          Length = 6884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267515
          Length = 6899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267514
          Length = 6908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267513
          Length = 6921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267512
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_005267511
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SIRKEAESS 9
            +I K+AESS
Sbjct: 2099 TIMKQAESS 2107
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 468 VRKEAEKT 475
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 468 VRKEAEKT 475
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IRKEAESS 9
           +RKEAE +
Sbjct: 467 VRKEAEKT 474
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.280   0.0979    0.202 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 395,721
Number of extensions: 472
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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