Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     509
NP_001243495                                                           17    2528
NP_004092                                                              17    2528
NP_066301                                                              17    3301
NP_065434                                                              17    3301
XP_005254491                                                           17    3301
XP_005268848                                                           17    3301
XP_005268846                                                           17    3301
XP_005268845                                                           17    3301
XP_005268844                                                           17    3301
XP_005268843                                                           17    3301
XP_005251089                                                           17    3301
XP_005251088                                                           17    3301
NP_057329                                                              17    4312
NP_001005172                                                           17    4312
NP_060720                                                              17    4312
NP_009171                                                              17    4312
NP_001166033                                                           17    4312
XP_006716420                                                           17    4312
XP_006716419                                                           17    4312
XP_006714295                                                           17    4312
XP_005244919                                                           17    4312
NP_001138631                                                           17    4312
NP_001135780                                                           17    4312
NP_079461                                                              16    5631
XP_005257260                                                           16    5631
XP_005257258                                                           16    5631
XP_006721872                                                           16    5631
XP_006721871                                                           16    5631
XP_006721870                                                           16    5631
XP_006721869                                                           16    5631
NP_005674                                                              16    7355
NP_001018048                                                           16    7355
NP_056001                                                              16    7355
NP_001018047                                                           16    7355
NP_150648                                                              16    7355
NP_004264                                                              16    7355
NP_001263280                                                           16    7355
NP_569707                                                              16    7355
NP_002831                                                              16    7355
NP_001005171                                                           16    7355
XP_006718138                                                           16    7355
XP_005247009                                                           16    7355
XP_006710864                                                           16    7355
XP_005271139                                                           16    7355
XP_006710863                                                           16    7355
XP_006710862                                                           16    7355
XP_006710861                                                           16    7355
XP_005271138                                                           16    7355
XP_006710860                                                           16    7355
XP_006710859                                                           16    7355
XP_005271137                                                           16    7355
XP_006710858                                                           16    7355
XP_005271136                                                           16    7355
NP_803875                                                              16    7355
NP_598375                                                              15    9605
NP_055855                                                              15    9605
NP_689884                                                              15    9605
NP_001171471                                                           15    9605
NP_002282                                                              15    9605
NP_689975                                                              15    9605
XP_005262773                                                           15    9605
XP_006714140                                                           15    9605
XP_006714139                                                           15    9605
XP_005262771                                                           15    9605
XP_005262770                                                           15    9605
XP_005262769                                                           15    9605
XP_005262768                                                           15    9605
NP_068747                                                              15    9605
>NP_073713
          Length = 985

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIPFKMAYE 9
           SIP KMAYE
Sbjct: 263 SIPSKMAYE 271
>NP_001243495
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SIPFKMAY 8
           ++PFK+AY
Sbjct: 123 TLPFKIAY 130
>NP_004092
          Length = 374

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SIPFKMAY 8
           ++PFK+AY
Sbjct: 145 TLPFKIAY 152
>NP_066301
          Length = 538

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIPFKMAY 8
           SIP KM Y
Sbjct: 243 SIPLKMCY 250
>NP_065434
          Length = 573

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 435 PFQLAYE 441
>XP_005254491
          Length = 151

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IPFKMAY 8
           IPF+M+Y
Sbjct: 143 IPFRMSY 149
>XP_005268848
          Length = 422

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 284 PFQLAYE 290
>XP_005268846
          Length = 436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 298 PFQLAYE 304
>XP_005268845
          Length = 462

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 324 PFQLAYE 330
>XP_005268844
          Length = 483

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 345 PFQLAYE 351
>XP_005268843
          Length = 547

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PFKMAYE 9
           PF++AYE
Sbjct: 409 PFQLAYE 415
>XP_005251089
          Length = 480

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIPFKMAY 8
           SIP KM Y
Sbjct: 341 SIPLKMCY 348
>XP_005251088
          Length = 636

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIPFKMAY 8
           SIP KM Y
Sbjct: 341 SIPLKMCY 348
>NP_057329
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           S+PF +AY
Sbjct: 178 SVPFLLAY 185
>NP_001005172
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIPFKMAY 8
          SIPF +AY
Sbjct: 30 SIPFCLAY 37
>NP_060720
          Length = 658

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           ++PFK  YE
Sbjct: 506 ALPFKRRYE 514
>NP_009171
          Length = 340

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IPFKMAYE 9
           +PF+ AYE
Sbjct: 136 LPFEKAYE 143
>NP_001166033
          Length = 634

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           ++PFK  YE
Sbjct: 482 ALPFKRRYE 490
>XP_006716420
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           ++PFK  YE
Sbjct: 506 ALPFKRRYE 514
>XP_006716419
          Length = 676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           ++PFK  YE
Sbjct: 506 ALPFKRRYE 514
>XP_006714295
          Length = 256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           S+PF +AY
Sbjct: 134 SVPFLLAY 141
>XP_005244919
          Length = 210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IPFKMAYE 9
          +PF+ AYE
Sbjct: 6  LPFEKAYE 13
>NP_001138631
          Length = 637

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           ++PFK  YE
Sbjct: 485 ALPFKRRYE 493
>NP_001135780
          Length = 2156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    PFKMAYE 9
            PFK+A+E
Sbjct: 1862 PFKVAFE 1868
>NP_079461
          Length = 1990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1810 IPLKPAYE 1817
>XP_005257260
          Length = 1990

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1810 IPLKPAYE 1817
>XP_005257258
          Length = 2000

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1820 IPLKPAYE 1827
>XP_006721872
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1857 IPLKPAYE 1864
>XP_006721871
          Length = 2037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1857 IPLKPAYE 1864
>XP_006721870
          Length = 2064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1884 IPLKPAYE 1891
>XP_006721869
          Length = 2074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IPFKMAYE 9
            IP K AYE
Sbjct: 1894 IPLKPAYE 1901
>NP_005674
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SIPFKM 6
          S+PFKM
Sbjct: 76 SLPFKM 81
>NP_001018048
          Length = 3069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    IPFKMAY 8
            +P+K+AY
Sbjct: 2117 LPYKIAY 2123
>NP_056001
          Length = 3095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    IPFKMAY 8
            +P+K+AY
Sbjct: 2117 LPYKIAY 2123
>NP_001018047
          Length = 3135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    IPFKMAY 8
            +P+K+AY
Sbjct: 2078 LPYKIAY 2084
>NP_150648
          Length = 3174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    IPFKMAY 8
            +P+K+AY
Sbjct: 2117 LPYKIAY 2123
>NP_004264
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SIPFKMA 7
           S+PFK+A
Sbjct: 431 SMPFKLA 437
>NP_001263280
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SIPFKMAYE 9
           S PFK  YE
Sbjct: 371 SKPFKYIYE 379
>NP_569707
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1032 AVPFKILY 1039
>NP_002831
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1041 AVPFKILY 1048
>NP_001005171
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  SIPFKMAY 8
          SIPF  AY
Sbjct: 30 SIPFCFAY 37
>XP_006718138
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SIPFKMA 7
           S+PFK+A
Sbjct: 431 SMPFKLA 437
>XP_005247009
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SIPFKM 6
          S+PFKM
Sbjct: 76 SLPFKM 81
>XP_006710864
          Length = 1729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           ++PFK+ Y
Sbjct: 852 AVPFKILY 859
>XP_005271139
          Length = 1796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           ++PFK+ Y
Sbjct: 930 AVPFKILY 937
>XP_006710863
          Length = 1811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           ++PFK+ Y
Sbjct: 934 AVPFKILY 941
>XP_006710862
          Length = 1820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           ++PFK+ Y
Sbjct: 943 AVPFKILY 950
>XP_006710861
          Length = 1902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1036 AVPFKILY 1043
>XP_005271138
          Length = 1909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1032 AVPFKILY 1039
>XP_006710860
          Length = 1911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1045 AVPFKILY 1052
>XP_006710859
          Length = 1913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1036 AVPFKILY 1043
>XP_005271137
          Length = 1918

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1041 AVPFKILY 1048
>XP_006710858
          Length = 1922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1045 AVPFKILY 1052
>XP_005271136
          Length = 1922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SIPFKMAY 8
            ++PFK+ Y
Sbjct: 1045 AVPFKILY 1052
>NP_803875
          Length = 4243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIPFKMAY 8
           S P KMAY
Sbjct: 248 SFPQKMAY 255
>NP_598375
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 635 TIPFGVAY 642
>NP_055855
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  PFKMAY 8
          PFK AY
Sbjct: 41 PFKSAY 46
>NP_689884
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  PFKMAY 8
          PFK AY
Sbjct: 41 PFKSAY 46
>NP_001171471
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  PFKMAY 8
          PFK AY
Sbjct: 41 PFKSAY 46
>NP_002282
          Length = 1786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           +IP+ M Y+
Sbjct: 603 NIPYSMEYD 611
>NP_689975
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIPFKMAYE 9
           S PF+ A+E
Sbjct: 105 SFPFQWAWE 113
>XP_005262773
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SIPFKMAY 8
          +IPF +AY
Sbjct: 91 TIPFGVAY 98
>XP_006714140
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 263 TIPFGVAY 270
>XP_006714139
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 635 TIPFGVAY 642
>XP_005262771
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 529 TIPFGVAY 536
>XP_005262770
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 529 TIPFGVAY 536
>XP_005262769
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 568 TIPFGVAY 575
>XP_005262768
          Length = 1064

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SIPFKMAY 8
           +IPF +AY
Sbjct: 598 TIPFGVAY 605
>NP_068747
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SIPFKMAYE 9
           S+PF   YE
Sbjct: 167 SVPFPDTYE 175
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.135    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 558,247
Number of extensions: 898
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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