Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_065988                                                              16    5631
XP_005267986                                                           16    5631
NP_006690                                                              16    7355
NP_008971                                                              16    7355
NP_653333                                                              16    7355
XP_005258523                                                           16    7355
XP_005258522                                                           16    7355
XP_005258520                                                           16    7355
XP_005258521                                                           16    7355
XP_005258519                                                           16    7355
XP_005258518                                                           16    7355
XP_005258516                                                           16    7355
XP_006710365                                                           16    7355
NP_001185498                                                           16    7355
NP_001685                                                              16    7355
NP_001166126                                                           15    9605
NP_060730                                                              15    9605
NP_699197                                                              15    9605
NP_001004301                                                           15    9605
NP_114102                                                              15    9605
NP_002263                                                              15    9605
NP_065856                                                              15    9605
XP_005259182                                                           15    9605
XP_006723069                                                           15    9605
XP_006722575                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SINDEISVS 9
            SI+DEISVS
Sbjct: 1564 SIHDEISVS 1572
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SINDEISVS 9
            SI+DEISVS
Sbjct: 1564 SIHDEISVS 1572
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SINDEISVS 9
            SI+DEISVS
Sbjct: 1564 SIHDEISVS 1572
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SINDEISVS 9
            SI+DEISVS
Sbjct: 1564 SIHDEISVS 1572
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SINDEISVS 9
            SI+DEISVS
Sbjct: 1564 SIHDEISVS 1572
>NP_065988
          Length = 2048

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           S NDE SVS
Sbjct: 948 SFNDEKSVS 956
>XP_005267986
          Length = 2022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           S NDE SVS
Sbjct: 922 SFNDEKSVS 930
>NP_006690
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SINDEISV 8
           S+N E+SV
Sbjct: 257 SVNSEVSV 264
>NP_008971
          Length = 856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 263 INEEISV 269
>NP_653333
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 163 INEEISV 169
>XP_005258523
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 163 INEEISV 169
>XP_005258522
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 163 INEEISV 169
>XP_005258520
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 163 INEEISV 169
>XP_005258521
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 163 INEEISV 169
>XP_005258519
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 174 INEEISV 180
>XP_005258518
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 174 INEEISV 180
>XP_005258516
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           IN+EISV
Sbjct: 263 INEEISV 269
>XP_006710365
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SINDEISV 8
           S+N E+SV
Sbjct: 257 SVNSEVSV 264
>NP_001185498
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SINDEISV 8
          S+ND+IS+
Sbjct: 79 SLNDDISL 86
>NP_001685
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SINDEISV 8
          S+ND+IS+
Sbjct: 79 SLNDDISL 86
>NP_001166126
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           +IND  SVS
Sbjct: 233 AINDAFSVS 241
>NP_060730
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           +IND  SVS
Sbjct: 167 AINDAFSVS 175
>NP_699197
          Length = 3571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SINDEISVS 9
            S+N ++SVS
Sbjct: 3198 SVNRQVSVS 3206
>NP_001004301
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           SIND  S+S
Sbjct: 167 SINDASSIS 175
>NP_114102
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SINDEI 6
           SINDE+
Sbjct: 155 SINDEV 160
>NP_002263
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SINDEIS 7
           S+NDEI+
Sbjct: 264 SLNDEIN 270
>NP_065856
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           +ND+ISV
Sbjct: 177 LNDQISV 183
>XP_005259182
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SINDEI 6
           SINDE+
Sbjct: 155 SINDEV 160
>XP_006723069
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SINDEISVS 9
           SIND  S+S
Sbjct: 167 SINDASSIS 175
>XP_006722575
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   INDEISV 8
           +ND+ISV
Sbjct: 221 LNDQISV 227
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.293    0.116    0.259 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 461,698
Number of extensions: 549
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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