Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_006718908                                                           19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_775922                                                              17    4312
NP_001275988                                                           16    7355
NP_001275990                                                           16    7355
NP_001275987                                                           16    7355
NP_112168                                                              16    7355
XP_006718343                                                           16    7355
XP_006718342                                                           16    7355
XP_006718341                                                           16    7355
NP_001095896                                                           15    9605
NP_006531                                                              15    9605
NP_443161                                                              15    9605
NP_001129628                                                           15    9605
NP_000250                                                              15    9605
NP_001135967                                                           15    9605
NP_001137359                                                           15    9605
NP_775105                                                              15    9605
NP_001036148                                                           15    9605
NP_004279                                                              15    9605
NP_004227                                                              15    9605
NP_055725                                                              15    9605
XP_005254459                                                           15    9605
XP_005254458                                                           15    9605
XP_005254457                                                           15    9605
XP_005254456                                                           15    9605
XP_005254455                                                           15    9605
XP_005254454                                                           15    9605
XP_005251190                                                           15    9605
XP_005251188                                                           15    9605
XP_005251189                                                           15    9605
XP_005251187                                                           15    9605
XP_005251186                                                           15    9605
XP_005251185                                                           15    9605
XP_006715506                                                           15    9605
XP_006715505                                                           15    9605
XP_006715504                                                           15    9605
XP_006715503                                                           15    9605
XP_006715502                                                           15    9605
XP_005263921                                                           15    9605
XP_005263920                                                           15    9605
XP_005263919                                                           15    9605
XP_006710380                                                           15    9605
XP_005245788                                                           15    9605
XP_006710379                                                           15    9605
XP_006710378                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 2310 SILKQMIKK 2318
>XP_006718908
          Length = 1708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SILKQMIKQ 9
           SILKQMIK+
Sbjct: 962 SILKQMIKK 970
>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 1962 SILKQMIKK 1970
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 2304 SILKQMIKK 2312
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 2310 SILKQMIKK 2318
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 2310 SILKQMIKK 2318
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SILKQMIKQ 9
            SILKQMIK+
Sbjct: 2310 SILKQMIKK 2318
>NP_775922
          Length = 6996

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SILKQMIK 8
            SILK+M+K
Sbjct: 1201 SILKEMLK 1208
>NP_001275988
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 169 SVLKQLMK 176
>NP_001275990
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 356 SVLKQLMK 363
>NP_001275987
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 315 SVLKQLMK 322
>NP_112168
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 356 SVLKQLMK 363
>XP_006718343
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 315 SVLKQLMK 322
>XP_006718342
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 356 SVLKQLMK 363
>XP_006718341
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LKQ++K
Sbjct: 315 SVLKQLMK 322
>NP_001095896
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKQMIK 8
           LKQMIK
Sbjct: 967 LKQMIK 972
>NP_006531
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>NP_443161
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SILKQMIKQ 9
           S+LK+ +KQ
Sbjct: 392 SVLKEELKQ 400
>NP_001129628
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SILKQMIKQ 9
           S+LK  IKQ
Sbjct: 138 SVLKDHIKQ 146
>NP_000250
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1684 LIKQVVKQ 1691
>NP_001135967
          Length = 1828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1657 LIKQVVKQ 1664
>NP_001137359
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LKQMIK 8
          LKQMIK
Sbjct: 72 LKQMIK 77
>NP_775105
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>NP_001036148
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>NP_004279
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ILKQMIKQ 9
           +LKQ +KQ
Sbjct: 180 VLKQTLKQ 187
>NP_004227
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LKQMIK 8
          LKQMIK
Sbjct: 72 LKQMIK 77
>NP_055725
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SILKQMIKQ 9
           S+LK  IKQ
Sbjct: 138 SVLKDHIKQ 146
>XP_005254459
          Length = 1825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1654 LIKQVVKQ 1661
>XP_005254458
          Length = 1852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1681 LIKQVVKQ 1688
>XP_005254457
          Length = 1853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1682 LIKQVVKQ 1689
>XP_005254456
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1706 LIKQVVKQ 1713
>XP_005254455
          Length = 1880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1709 LIKQVVKQ 1716
>XP_005254454
          Length = 1880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    ILKQMIKQ 9
            ++KQ++KQ
Sbjct: 1709 LIKQVVKQ 1716
>XP_005251190
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_005251188
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_005251189
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_005251187
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_005251186
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_005251185
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SILKQMIKQ 9
          +ILK+ +KQ
Sbjct: 71 AILKETVKQ 79
>XP_006715506
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>XP_006715505
          Length = 1673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>XP_006715504
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>XP_006715503
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>XP_006715502
          Length = 1707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SILKQMIK 8
           S+LK+M+K
Sbjct: 481 SLLKRMLK 488
>XP_005263921
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKQMIK 8
           LKQMIK
Sbjct: 974 LKQMIK 979
>XP_005263920
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKQMIK 8
           LKQMIK
Sbjct: 982 LKQMIK 987
>XP_005263919
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LKQMIK 8
           LKQMIK
Sbjct: 989 LKQMIK 994
>XP_006710380
          Length = 1398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SILKQMIKQ 9
           S+LK+ +KQ
Sbjct: 392 SVLKEELKQ 400
>XP_005245788
          Length = 1434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SILKQMIKQ 9
           S+LK+ +KQ
Sbjct: 392 SVLKEELKQ 400
>XP_006710379
          Length = 1452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SILKQMIKQ 9
           S+LK+ +KQ
Sbjct: 392 SVLKEELKQ 400
>XP_006710378
          Length = 1478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SILKQMIKQ 9
           S+LK+ +KQ
Sbjct: 392 SVLKEELKQ 400
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.131    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 329,928
Number of extensions: 631
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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