Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     299
XP_006717989                                                           20     299
NP_660335                                                              16    5631
NP_003310                                                              16    5631
NP_597676                                                              16    5631
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
NP_001230050                                                           16    5631
XP_006715926                                                           16    5631
XP_006715925                                                           16    5631
XP_005246888                                                           16    5631
XP_006712788                                                           16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
NP_001254479                                                           16    5631
NP_597681                                                              16    5631
NP_001244197                                                           16    7355
NP_015568                                                              16    7355
NP_004397                                                              16    7355
NP_060049                                                              16    7355
XP_006717742                                                           16    7355
XP_006717741                                                           16    7355
XP_006717740                                                           16    7355
XP_006717739                                                           16    7355
XP_006717738                                                           16    7355
XP_006717737                                                           16    7355
XP_006717736                                                           16    7355
XP_006717735                                                           16    7355
XP_006717734                                                           16    7355
XP_006717733                                                           16    7355
XP_006717732                                                           16    7355
XP_006717731                                                           16    7355
XP_006717730                                                           16    7355
XP_006717729                                                           16    7355
XP_006717728                                                           16    7355
XP_006717727                                                           16    7355
XP_006717726                                                           16    7355
XP_006717725                                                           16    7355
XP_006717724                                                           16    7355
XP_006717723                                                           16    7355
NP_001166176                                                           15    9605
NP_001036024                                                           15    9605
NP_001409                                                              15    9605
NP_001010888                                                           15    9605
NP_569733                                                              15    9605
NP_904324                                                              15    9605
NP_004703                                                              15    9605
NP_001032961                                                           15    9605
NP_001363                                                              15    9605
NP_057400                                                              15    9605
NP_001254795                                                           15    9605
NP_001093629                                                           15    9605
NP_001254794                                                           15    9605
XP_005262317                                                           15    9605
XP_005257851                                                           15    9605
XP_006721530                                                           15    9605
XP_006721529                                                           15    9605
XP_006721528                                                           15    9605
XP_006719745                                                           15    9605
XP_006719744                                                           15    9605
XP_005254044                                                           15    9605
XP_006715713                                                           15    9605
XP_006715712                                                           15    9605
XP_006712655                                                           15    9605
>NP_000305
          Length = 403

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SIKRADNDK 9
           SI+RADNDK
Sbjct: 305 SIERADNDK 313
>XP_006717989
          Length = 388

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SIKRADNDK 9
           SI+RADNDK
Sbjct: 290 SIERADNDK 298
>NP_660335
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IKRADNDK 9
          +KR D DK
Sbjct: 70 VKRTDEDK 77
>NP_003310
          Length = 26926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 13130 VKRADSD 13136
>NP_597676
          Length = 27051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 13255 VKRADSD 13261
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 20554 VKRADSD 20560
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 19627 VKRADSD 19633
>NP_001230050
          Length = 864

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIKRADND 8
          SI RA+ND
Sbjct: 77 SITRAEND 84
>XP_006715926
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IKRADNDK 9
          +KR D DK
Sbjct: 70 VKRTDEDK 77
>XP_006715925
          Length = 443

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IKRADNDK 9
          +KR D DK
Sbjct: 70 VKRTDEDK 77
>XP_005246888
          Length = 22663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKRADND 8
            +KRAD+D
Sbjct: 8867 VKRADSD 8873
>XP_006712788
          Length = 24022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 10226 VKRADSD 10232
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 20182 VKRADSD 20188
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 21688 VKRADSD 21694
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 22195 VKRADSD 22201
>NP_597681
          Length = 27118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     IKRADND 8
             +KRAD+D
Sbjct: 13322 VKRADSD 13328
>NP_001244197
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SIKRADNDK 9
           S KRAD D+
Sbjct: 157 SSKRADKDE 165
>NP_015568
          Length = 2413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2182 TFKQADND 2189
>NP_004397
          Length = 1785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 1554 TFKQADND 1561
>NP_060049
          Length = 2403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2172 TFKQADND 2179
>XP_006717742
          Length = 1750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 1519 TFKQADND 1526
>XP_006717741
          Length = 2266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2035 TFKQADND 2042
>XP_006717740
          Length = 2374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2143 TFKQADND 2150
>XP_006717739
          Length = 2387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2156 TFKQADND 2163
>XP_006717738
          Length = 2387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2156 TFKQADND 2163
>XP_006717737
          Length = 2395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2164 TFKQADND 2171
>XP_006717736
          Length = 2395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2164 TFKQADND 2171
>XP_006717735
          Length = 2395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2164 TFKQADND 2171
>XP_006717734
          Length = 2397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2166 TFKQADND 2173
>XP_006717733
          Length = 2397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2166 TFKQADND 2173
>XP_006717732
          Length = 2397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2166 TFKQADND 2173
>XP_006717731
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2187 TFKQADND 2194
>XP_006717730
          Length = 2505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2274 TFKQADND 2281
>XP_006717729
          Length = 2505

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2274 TFKQADND 2281
>XP_006717728
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2279 TFKQADND 2286
>XP_006717727
          Length = 2516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2285 TFKQADND 2292
>XP_006717726
          Length = 2516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2285 TFKQADND 2292
>XP_006717725
          Length = 2516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2285 TFKQADND 2292
>XP_006717724
          Length = 2516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2285 TFKQADND 2292
>XP_006717723
          Length = 2526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIKRADND 8
            + K+ADND
Sbjct: 2295 TFKQADND 2302
>NP_001166176
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIKRADNDK 9
           S+ R+D DK
Sbjct: 589 SLDRSDEDK 597
>NP_001036024
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIKRADNDK 9
           S+ R+D DK
Sbjct: 551 SLDRSDEDK 559
>NP_001409
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIKRADNDK 9
           S+ R+D DK
Sbjct: 589 SLDRSDEDK 597
>NP_001010888
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SIKRADNDK 9
          S+K +DN K
Sbjct: 50 SLKSSDNSK 58
>NP_569733
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIKRADND 8
           SIKR D D
Sbjct: 832 SIKRYDGD 839
>NP_904324
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIKRADND 8
           SIKR D D
Sbjct: 832 SIKRYDGD 839
>NP_004703
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SIKRADNDK 9
          SIK+  NDK
Sbjct: 48 SIKKKVNDK 56
>NP_001032961
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  KRADND 8
          KRA+ND
Sbjct: 8  KRAEND 13
>NP_001363
          Length = 4486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SIKRADNDK 9
            S+KR D D+
Sbjct: 2056 SLKRGDPDR 2064
>NP_057400
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  KRADND 8
          KRA+ND
Sbjct: 8  KRAEND 13
>NP_001254795
          Length = 153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KRADNDK 9
          +RAD+DK
Sbjct: 92 QRADSDK 98
>NP_001093629
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KRADNDK 9
           +RAD+DK
Sbjct: 230 QRADSDK 236
>NP_001254794
          Length = 157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KRADNDK 9
          +RAD+DK
Sbjct: 92 QRADSDK 98
>XP_005262317
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SIKRADNDK 9
          S+K +DN K
Sbjct: 50 SLKSSDNSK 58
>XP_005257851
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  SIKRADNDK 9
          SIK+  NDK
Sbjct: 39 SIKKKVNDK 47
>XP_006721530
          Length = 2746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SIKRADNDK 9
            S+KR D D+
Sbjct: 2056 SLKRGDPDR 2064
>XP_006721529
          Length = 2817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SIKRADNDK 9
            S+KR D D+
Sbjct: 2056 SLKRGDPDR 2064
>XP_006721528
          Length = 3869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SIKRADNDK 9
            S+KR D D+
Sbjct: 2056 SLKRGDPDR 2064
>XP_006719745
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIKRADND 8
           SIKR D D
Sbjct: 832 SIKRYDGD 839
>XP_006719744
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIKRADND 8
           SIKR D D
Sbjct: 832 SIKRYDGD 839
>XP_005254044
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SIKRADND 8
           SIKR D D
Sbjct: 832 SIKRYDGD 839
>XP_006715713
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KRADNDK 9
           +RAD+DK
Sbjct: 108 QRADSDK 114
>XP_006715712
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KRADNDK 9
           +RAD+DK
Sbjct: 230 QRADSDK 236
>XP_006712655
          Length = 1251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  KRADND 8
          KRA+ND
Sbjct: 8  KRAEND 13
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.121    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 564,359
Number of extensions: 1130
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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