Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_055029                                                              18    1482
NP_001029097                                                           17    4312
XP_006718022                                                           17    4312
XP_005270165                                                           17    4312
NP_001786                                                              16    5631
NP_005756                                                              16    5631
NP_003957                                                              16    5631
NP_001243275                                                           16    5631
NP_001026872                                                           16    5631
NP_001243277                                                           16    5631
NP_001243276                                                           16    5631
XP_006714571                                                           16    5631
XP_006714570                                                           16    5631
XP_006714569                                                           16    5631
NP_057002                                                              16    5631
NP_056390                                                              16    7355
NP_001096616                                                           16    7355
NP_001096618                                                           16    7355
NP_001096617                                                           16    7355
NP_060811                                                              16    7355
NP_001265460                                                           16    7355
NP_001265462                                                           16    7355
XP_006725074                                                           16    7355
XP_006725073                                                           16    7355
XP_006715929                                                           16    7355
XP_005250018                                                           16    7355
XP_005250017                                                           16    7355
XP_005250016                                                           16    7355
XP_006715928                                                           16    7355
XP_006715927                                                           16    7355
XP_006715573                                                           16    7355
XP_006715572                                                           16    7355
NP_997219                                                              16    7355
NP_000477                                                              15    9605
NP_036596                                                              15    9605
NP_060151                                                              15    9605
NP_056379                                                              15    9605
NP_787074                                                              15    9605
NP_003921                                                              15    9605
NP_060066                                                              15    9605
NP_001239029                                                           15    9605
NP_001239032                                                           15    9605
NP_001239031                                                           15    9605
NP_001191689                                                           15    9605
XP_005254804                                                           15    9605
XP_006720791                                                           15    9605
XP_005254803                                                           15    9605
XP_005254800                                                           15    9605
XP_005254799                                                           15    9605
XP_005249958                                                           15    9605
XP_006714356                                                           15    9605
NP_004937                                                              15    9605
NP_003913                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 677 SIGFSVHQN 685
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 329 SIGFSVHQN 337
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 677 SIGFSVHQN 685
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 677 SIGFSVHQN 685
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 677 SIGFSVHQN 685
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIGFSVRQN 9
           SIGFSV QN
Sbjct: 677 SIGFSVHQN 685
>NP_055029
          Length = 288

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SIGFSVRQ 8
           SIGF+VRQ
Sbjct: 119 SIGFAVRQ 126
>NP_001029097
          Length = 392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          S+GFSV Q+
Sbjct: 53 SVGFSVLQH 61
>XP_006718022
          Length = 309

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          S+GFSV Q+
Sbjct: 53 SVGFSVLQH 61
>XP_005270165
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          S+GFSV Q+
Sbjct: 14 SVGFSVLQH 22
>NP_001786
          Length = 784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SIGFSVRQ 8
           SIG+S+R+
Sbjct: 404 SIGYSIRR 411
>NP_005756
          Length = 350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SIGFSVRQN 9
          S+GFSV+++
Sbjct: 49 SMGFSVKED 57
>NP_003957
          Length = 1074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 613 IGFQVRQ 619
>NP_001243275
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 682 IGFQVRQ 688
>NP_001026872
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 682 IGFQVRQ 688
>NP_001243277
          Length = 1057

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 624 IGFQVRQ 630
>NP_001243276
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 736 IGFQVRQ 742
>XP_006714571
          Length = 917

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 456 IGFQVRQ 462
>XP_006714570
          Length = 1074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 613 IGFQVRQ 619
>XP_006714569
          Length = 1074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGFSVRQ 8
           IGF VRQ
Sbjct: 613 IGFQVRQ 619
>NP_057002
          Length = 163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SIGFSVR 7
          SIGF+VR
Sbjct: 50 SIGFAVR 56
>NP_056390
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIGFSVRQN 9
            S+G S RQN
Sbjct: 1104 SVGVSNRQN 1112
>NP_001096616
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIGFSVRQN 9
            S+G S RQN
Sbjct: 1104 SVGVSNRQN 1112
>NP_001096618
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIGFSVRQN 9
            S+G S RQN
Sbjct: 1098 SVGVSNRQN 1106
>NP_001096617
          Length = 1320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SIGFSVRQN 9
            S+G S RQN
Sbjct: 1125 SVGVSNRQN 1133
>NP_060811
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 23 NLGFQLREN 31
>NP_001265460
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 23 NLGFQLREN 31
>NP_001265462
          Length = 605

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 23 NLGFQLREN 31
>XP_006725074
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 33 NLGFQLREN 41
>XP_006725073
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 33 NLGFQLREN 41
>XP_006715929
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 10 SLGFSVGQ 17
>XP_005250018
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 10 SLGFSVGQ 17
>XP_005250017
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 10 SLGFSVGQ 17
>XP_005250016
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 10 SLGFSVGQ 17
>XP_006715928
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 51 SLGFSVGQ 58
>XP_006715927
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 51 SLGFSVGQ 58
>XP_006715573
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 33 NLGFQLREN 41
>XP_006715572
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  SIGFSVRQN 9
          ++GF +R+N
Sbjct: 33 NLGFQLREN 41
>NP_997219
          Length = 595

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SIGFSVRQ 8
          S+GFSV Q
Sbjct: 10 SLGFSVGQ 17
>NP_000477
          Length = 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SIGFSV 6
           SIGFSV
Sbjct: 163 SIGFSV 168
>NP_036596
          Length = 1013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IGFSVRQN 9
           IGF + QN
Sbjct: 118 IGFGLEQN 125
>NP_060151
          Length = 184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  GFSVRQN 9
          GF+V QN
Sbjct: 41 GFTVNQN 47
>NP_056379
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SIGFSVRQN 9
          S+G S+R N
Sbjct: 63 SLGLSLRHN 71
>NP_787074
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IGFSVRQN 9
           I FS+R N
Sbjct: 149 IAFSIRDN 156
>NP_003921
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GFSVRQN 9
           G+SVR N
Sbjct: 168 GYSVRMN 174
>NP_060066
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IGFSVR 7
            +GFSVR
Sbjct: 1179 VGFSVR 1184
>NP_001239029
          Length = 1637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IGFSVR 7
            +GFSVR
Sbjct: 1179 VGFSVR 1184
>NP_001239032
          Length = 1610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IGFSVR 7
            +GFSVR
Sbjct: 1179 VGFSVR 1184
>NP_001239031
          Length = 1623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IGFSVR 7
            +GFSVR
Sbjct: 1179 VGFSVR 1184
>NP_001191689
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   IGFSVRQN 9
           IGF + QN
Sbjct: 118 IGFGLEQN 125
>XP_005254804
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2695 MGFSLRQ 2701
>XP_006720791
          Length = 4853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2752 MGFSLRQ 2758
>XP_005254803
          Length = 4854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2760 MGFSLRQ 2766
>XP_005254800
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2760 MGFSLRQ 2766
>XP_005254799
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2760 MGFSLRQ 2766
>XP_005249958
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GFSVRQN 9
           G+SVR N
Sbjct: 168 GYSVRMN 174
>XP_006714356
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  IGFSVRQN 9
          IGF + QN
Sbjct: 69 IGFGLEQN 76
>NP_004937
          Length = 1830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    IGFSVR 7
            IGFS+R
Sbjct: 1066 IGFSIR 1071
>NP_003913
          Length = 4861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IGFSVRQ 8
            +GFS+RQ
Sbjct: 2760 MGFSLRQ 2766
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.133    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 396,336
Number of extensions: 657
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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