Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           19     869
NP_000170                                                              19     869
NP_001268422                                                           19     869
NP_001268423                                                           19     869
XP_005264328                                                           19     869
NP_056508                                                              16    5631
NP_057646                                                              16    7355
NP_001277131                                                           16    7355
NP_849191                                                              16    7355
NP_001092105                                                           16    7355
NP_998771                                                              16    7355
NP_001136277                                                           15    9605
NP_005620                                                              15    9605
NP_115495                                                              15    9605
NP_001371                                                              15    9605
NP_001277152                                                           15    9605
NP_005519                                                              15    9605
NP_055043                                                              15    9605
NP_001269665                                                           15    9605
NP_001020016                                                           15    9605
NP_001139807                                                           15    9605
NP_060527                                                              15    9605
NP_116201                                                              15    9605
NP_877499                                                              15    9605
NP_964012                                                              15    9605
NP_008865                                                              15    9605
NP_001248309                                                           15    9605
NP_112195                                                              15    9605
NP_059132                                                              15    9605
XP_005261703                                                           15    9605
XP_005261705                                                           15    9605
XP_005261704                                                           15    9605
XP_005261701                                                           15    9605
XP_006724330                                                           15    9605
XP_006724329                                                           15    9605
XP_005261700                                                           15    9605
XP_006724328                                                           15    9605
XP_006718593                                                           15    9605
XP_006718592                                                           15    9605
XP_006713311                                                           15    9605
XP_006713310                                                           15    9605
XP_005264819                                                           15    9605
XP_006713309                                                           15    9605
XP_006710903                                                           15    9605
XP_006710057                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SIFFVELSE 9
            S FFVELSE
Sbjct: 1058 STFFVELSE 1066
>NP_000170
          Length = 1360

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SIFFVELSE 9
            S FFVELSE
Sbjct: 1188 STFFVELSE 1196
>NP_001268422
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIFFVELSE 9
           S FFVELSE
Sbjct: 886 STFFVELSE 894
>NP_001268423
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SIFFVELSE 9
           S FFVELSE
Sbjct: 886 STFFVELSE 894
>XP_005264328
          Length = 1261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SIFFVELSE 9
            S FFVELSE
Sbjct: 1089 STFFVELSE 1097
>NP_056508
          Length = 942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  IFFVELSE 9
          +F++ELSE
Sbjct: 65 LFYLELSE 72
>NP_057646
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SIFFVELSE 9
           SIFFV+ S+
Sbjct: 504 SIFFVKSSD 512
>NP_001277131
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FFVELS 8
           FFVELS
Sbjct: 380 FFVELS 385
>NP_849191
          Length = 994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FFVELS 8
           FFVELS
Sbjct: 505 FFVELS 510
>NP_001092105
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   FFVELS 8
           FFVELS
Sbjct: 505 FFVELS 510
>NP_998771
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SIFFVE 6
          SIFFVE
Sbjct: 70 SIFFVE 75
>NP_001136277
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           IFF+E+S
Sbjct: 105 IFFLEIS 111
>NP_005620
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           IFF+E+S
Sbjct: 105 IFFLEIS 111
>NP_115495
          Length = 6306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    FFVELSE 9
            FFVEL E
Sbjct: 5464 FFVELYE 5470
>NP_001371
          Length = 1865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIFFVELS 8
            S+F VE+S
Sbjct: 1481 SVFMVEIS 1488
>NP_001277152
          Length = 1886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SIFFVELS 8
            S+F VE+S
Sbjct: 1502 SVFMVEIS 1509
>NP_005519
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVELSE 9
          FVELSE
Sbjct: 76 FVELSE 81
>NP_055043
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IFFVELS 8
          +FF+ELS
Sbjct: 90 LFFLELS 96
>NP_001269665
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SIFFVE 6
           SIFF+E
Sbjct: 437 SIFFIE 442
>NP_001020016
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IFFVELS 8
          +FF+ELS
Sbjct: 80 LFFMELS 86
>NP_001139807
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IFFVELS 8
          +FF+ELS
Sbjct: 7  LFFLELS 13
>NP_060527
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           +FF+ELS
Sbjct: 114 LFFLELS 120
>NP_116201
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SIFFVE 6
           SIFF+E
Sbjct: 486 SIFFIE 491
>NP_877499
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           +FF+ELS
Sbjct: 114 LFFLELS 120
>NP_964012
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           +FF+ELS
Sbjct: 153 LFFMELS 159
>NP_008865
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           +FF+ELS
Sbjct: 99  LFFMELS 105
>NP_001248309
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IFFVELS 8
          +FF+ELS
Sbjct: 84 LFFMELS 90
>NP_112195
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SIFFVELSE 9
           S+FFV+  E
Sbjct: 166 SVFFVKYEE 174
>NP_059132
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_005261703
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_005261705
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_005261704
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_005261701
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_006724330
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_006724329
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_005261700
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_006724328
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SIFFVELSE 9
          +IFF+E S+
Sbjct: 78 NIFFLETSD 86
>XP_006718593
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVELSE 9
          FVELSE
Sbjct: 76 FVELSE 81
>XP_006718592
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  FVELSE 9
          FVELSE
Sbjct: 76 FVELSE 81
>XP_006713311
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SIFFVELS 8
           SIFF+E S
Sbjct: 185 SIFFLERS 192
>XP_006713310
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SIFFVELS 8
           SIFF+E S
Sbjct: 284 SIFFLERS 291
>XP_005264819
          Length = 1128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SIFFVELS 8
           SIFF+E S
Sbjct: 397 SIFFLERS 404
>XP_006713309
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SIFFVELS 8
           SIFF+E S
Sbjct: 397 SIFFLERS 404
>XP_006710903
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IFFVELS 8
           +FF+ELS
Sbjct: 153 LFFMELS 159
>XP_006710057
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  IFFVELS 8
          IFF+E+S
Sbjct: 47 IFFLEIS 53
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.144    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 318,146
Number of extensions: 229
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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