Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001242941                                                           17    4312
NP_077816                                                              17    4312
NP_005955                                                              17    4312
NP_001243024                                                           17    4312
XP_005256710                                                           17    4312
XP_005256709                                                           17    4312
XP_005256708                                                           17    4312
XP_006720682                                                           17    4312
XP_005268318                                                           17    4312
NP_055318                                                              16    5631
NP_006050                                                              16    5631
XP_006719406                                                           16    5631
XP_006718277                                                           16    5631
XP_006718275                                                           16    5631
XP_006718274                                                           16    5631
XP_006718272                                                           16    5631
NP_003635                                                              16    7355
NP_958836                                                              16    7355
NP_958839                                                              16    7355
NP_001124303                                                           16    7355
NP_055791                                                              16    7355
NP_113674                                                              16    7355
NP_001248389                                                           16    7355
NP_001007102                                                           16    7355
NP_001248387                                                           16    7355
NP_001269461                                                           16    7355
NP_056154                                                              16    7355
NP_001248388                                                           16    7355
NP_001269460                                                           16    7355
NP_060009                                                              16    7355
NP_852107                                                              16    7355
NP_056518                                                              16    7355
XP_006723822                                                           16    7355
XP_005256892                                                           16    7355
XP_005256891                                                           16    7355
XP_005256890                                                           16    7355
XP_005256888                                                           16    7355
XP_005256889                                                           16    7355
XP_006721125                                                           16    7355
XP_005269704                                                           16    7355
XP_006717362                                                           16    7355
XP_005252310                                                           16    7355
NP_060509                                                              15    9605
NP_001239264                                                           15    9605
NP_060388                                                              15    9605
NP_001258875                                                           15    9605
NP_001138608                                                           15    9605
NP_689451                                                              15    9605
NP_001138606                                                           15    9605
NP_003053                                                              15    9605
NP_001138607                                                           15    9605
NP_001138609                                                           15    9605
NP_689452                                                              15    9605
NP_004368                                                              15    9605
NP_001129201                                                           15    9605
NP_001129204                                                           15    9605
NP_005479                                                              15    9605
NP_001129202                                                           15    9605
NP_065757                                                              15    9605
NP_001138917                                                           15    9605
NP_001138916                                                           15    9605
NP_000479                                                              15    9605
NP_116255                                                              15    9605
XP_005261074                                                           15    9605
XP_006724099                                                           15    9605
XP_006724098                                                           15    9605
XP_005254784                                                           15    9605
XP_005254783                                                           15    9605
XP_006714309                                                           15    9605
XP_005245255                                                           15    9605
>NP_001242941
          Length = 2007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1402 SQLADTKKK 1410
>NP_077816
          Length = 1499

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HLADSRKK 9
          HLAD+R K
Sbjct: 58 HLADNRLK 65
>NP_005955
          Length = 1976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1371 SQLADTKKK 1379
>NP_001243024
          Length = 1985

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1380 SQLADTKKK 1388
>XP_005256710
          Length = 1986

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1381 SQLADTKKK 1389
>XP_005256709
          Length = 1997

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1392 SQLADTKKK 1400
>XP_005256708
          Length = 2007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SHLADSRKK 9
            S LAD++KK
Sbjct: 1402 SQLADTKKK 1410
>XP_006720682
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HLADSRKK 9
          HLAD+R K
Sbjct: 58 HLADNRLK 65
>XP_005268318
          Length = 1499

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  HLADSRKK 9
          HLAD+R K
Sbjct: 58 HLADNRLK 65
>NP_055318
          Length = 2785

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SHLADSRKK 9
            SH+ D R+K
Sbjct: 1131 SHILDQREK 1139
>NP_006050
          Length = 1575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LADSRKK 9
            LAD+RKK
Sbjct: 1370 LADTRKK 1376
>XP_006719406
          Length = 2380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    SHLADSRKK 9
            SH+ D R+K
Sbjct: 1131 SHILDQREK 1139
>XP_006718277
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SHLADS 6
           SHLADS
Sbjct: 334 SHLADS 339
>XP_006718275
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SHLADS 6
           SHLADS
Sbjct: 334 SHLADS 339
>XP_006718274
          Length = 811

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SHLADS 6
           SHLADS
Sbjct: 242 SHLADS 247
>XP_006718272
          Length = 903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SHLADS 6
           SHLADS
Sbjct: 334 SHLADS 339
>NP_003635
          Length = 336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 181 HIADLRKQ 188
>NP_958836
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 261 HIADLRKQ 268
>NP_958839
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 321 HIADLRKQ 328
>NP_001124303
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 257 HIADLRKQ 264
>NP_055791
          Length = 1871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SHLADSR 7
           SHL+DS+
Sbjct: 397 SHLSDSK 403
>NP_113674
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 166 THLVSSRKR 174
>NP_001248389
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 130 THLVSSRKR 138
>NP_001007102
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 130 THLVSSRKR 138
>NP_001248387
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 168 THLVSSRKR 176
>NP_001269461
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           SH ++ RKK
Sbjct: 802 SHFSNKRKK 810
>NP_056154
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           SH ++ RKK
Sbjct: 802 SHFSNKRKK 810
>NP_001248388
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 130 THLVSSRKR 138
>NP_001269460
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           SH ++ RKK
Sbjct: 802 SHFSNKRKK 810
>NP_060009
          Length = 4116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ADSRKK 9
            ADSRKK
Sbjct: 1969 ADSRKK 1974
>NP_852107
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           SH ++ RKK
Sbjct: 802 SHFSNKRKK 810
>NP_056518
          Length = 280

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HLADSRKK 9
           HLA  RKK
Sbjct: 253 HLAQLRKK 260
>XP_006723822
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           SH ++ RKK
Sbjct: 811 SHFSNKRKK 819
>XP_005256892
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 198 HIADLRKQ 205
>XP_005256891
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 198 HIADLRKQ 205
>XP_005256890
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 198 HIADLRKQ 205
>XP_005256888
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 257 HIADLRKQ 264
>XP_005256889
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           H+AD RK+
Sbjct: 257 HIADLRKQ 264
>XP_006721125
          Length = 4070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ADSRKK 9
            ADSRKK
Sbjct: 1923 ADSRKK 1928
>XP_005269704
          Length = 1872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SHLADSR 7
           SHL+DS+
Sbjct: 397 SHLSDSK 403
>XP_006717362
          Length = 831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 145 THLVSSRKR 153
>XP_005252310
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           +HL  SRK+
Sbjct: 183 THLVSSRKR 191
>NP_060509
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           HLA+S+K
Sbjct: 103 HLANSKK 109
>NP_001239264
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SHLADSRKK 9
            SHL D R +
Sbjct: 1053 SHLKDDRSR 1061
>NP_060388
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           HL +S+KK
Sbjct: 176 HLEESQKK 183
>NP_001258875
          Length = 1530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HLADSRK 8
           HL+DS K
Sbjct: 978 HLSDSHK 984
>NP_001138608
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_689451
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_001138606
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 294 HLSDSR 299
>NP_003053
          Length = 1523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HLADSRK 8
           HL+DS K
Sbjct: 971 HLSDSHK 977
>NP_001138607
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_001138609
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_689452
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_004368
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HL+DSR
Sbjct: 328 HLSDSR 333
>NP_001129201
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           S LAD RK+
Sbjct: 342 SSLADQRKE 350
>NP_001129204
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           S LAD RK+
Sbjct: 375 SSLADQRKE 383
>NP_005479
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           S LAD RK+
Sbjct: 375 SSLADQRKE 383
>NP_001129202
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SHLADSRKK 9
           S LAD RK+
Sbjct: 330 SSLADQRKE 338
>NP_065757
          Length = 1147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 427 HMSDNRK 433
>NP_001138917
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 427 HMSDNRK 433
>NP_001138916
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 412 HMSDNRK 418
>NP_000479
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HLADSR 7
           HLADS+
Sbjct: 97  HLADSK 102
>NP_116255
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SHLADSRKK 9
            SHL D R +
Sbjct: 1053 SHLKDDRSR 1061
>XP_005261074
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 368 HMSDNRK 374
>XP_006724099
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 427 HMSDNRK 433
>XP_006724098
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HLADSRK 8
           H++D+RK
Sbjct: 427 HMSDNRK 433
>XP_005254784
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SHLADSRKK 9
            SHL D R +
Sbjct: 1053 SHLKDDRSR 1061
>XP_005254783
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SHLADSRKK 9
            SHL D R +
Sbjct: 1053 SHLKDDRSR 1061
>XP_006714309
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HLADSRKK 9
           HL +S+KK
Sbjct: 147 HLEESQKK 154
>XP_005245255
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HLADSR 7
          HLADS+
Sbjct: 49 HLADSK 54
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.115    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 656,107
Number of extensions: 1337
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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