Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     509
NP_001020014                                                           20     509
NP_055903                                                              20     509
NP_006523                                                              17    2528
NP_001075956                                                           17    2528
NP_075065                                                              17    2528
XP_005256172                                                           17    2528
NP_001075955                                                           17    2528
NP_001191111                                                           17    3301
NP_714928                                                              17    3301
XP_005248009                                                           17    3301
XP_006713930                                                           17    3301
XP_006713929                                                           17    3301
XP_006713928                                                           17    3301
NP_060142                                                              17    4312
NP_005985                                                              17    4312
XP_006720645                                                           17    4312
XP_005254546                                                           17    4312
XP_005254545                                                           17    4312
XP_005254544                                                           17    4312
XP_005254543                                                           17    4312
NP_001640                                                              16    5631
XP_005274557                                                           16    5631
NP_114431                                                              16    7355
NP_001156889                                                           16    7355
NP_001156890                                                           16    7355
NP_002438                                                              16    7355
NP_001231866                                                           16    7355
NP_060103                                                              16    7355
XP_005272167                                                           16    7355
XP_005272166                                                           16    7355
XP_006714782                                                           16    7355
XP_006714781                                                           16    7355
XP_005272165                                                           16    7355
XP_005272164                                                           16    7355
XP_005272163                                                           16    7355
XP_005272162                                                           16    7355
XP_005272161                                                           16    7355
XP_005272160                                                           16    7355
XP_006714780                                                           16    7355
XP_005265227                                                           16    7355
NP_116165                                                              15    9605
NP_001269877                                                           15    9605
NP_055737                                                              15    9605
NP_001028225                                                           15    9605
NP_207646                                                              15    9605
NP_127497                                                              15    9605
NP_127500                                                              15    9605
NP_061852                                                              15    9605
NP_127499                                                              15    9605
NP_777603                                                              15    9605
NP_001229725                                                           15    9605
NP_001229724                                                           15    9605
NP_055484                                                              15    9605
NP_001167449                                                           15    9605
XP_005256320                                                           15    9605
XP_006720345                                                           15    9605
XP_005268192                                                           15    9605
XP_005268191                                                           15    9605
XP_006719066                                                           15    9605
XP_005253800                                                           15    9605
XP_005253795                                                           15    9605
XP_005253794                                                           15    9605
XP_005253793                                                           15    9605
XP_005253792                                                           15    9605
XP_006719061                                                           15    9605
XP_005253791                                                           15    9605
XP_005269685                                                           15    9605
XP_005269684                                                           15    9605
XP_005269683                                                           15    9605
XP_005269681                                                           15    9605
XP_006717770                                                           15    9605
XP_005269679                                                           15    9605
NP_005693                                                              15    9605
>NP_001155973
          Length = 1833

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHFLAQAQP 9
            S FLAQAQP
Sbjct: 1724 SRFLAQAQP 1732
>NP_001020014
          Length = 1029

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SHFLAQAQP 9
           S FLAQAQP
Sbjct: 920 SRFLAQAQP 928
>NP_055903
          Length = 1723

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHFLAQAQP 9
            S FLAQAQP
Sbjct: 1614 SRFLAQAQP 1622
>NP_006523
          Length = 621

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           SHF  +AQP
Sbjct: 342 SHFTQRAQP 350
>NP_001075956
          Length = 528

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HFLAQAQP 9
           HFL  AQP
Sbjct: 514 HFLMDAQP 521
>NP_075065
          Length = 541

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HFLAQAQP 9
           HFL  AQP
Sbjct: 527 HFLMDAQP 534
>XP_005256172
          Length = 515

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HFLAQAQP 9
           HFL  AQP
Sbjct: 501 HFLMDAQP 508
>NP_001075955
          Length = 544

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HFLAQAQP 9
           HFL  AQP
Sbjct: 530 HFLMDAQP 537
>NP_001191111
          Length = 388

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SHFLAQA 7
           SHF+AQA
Sbjct: 372 SHFVAQA 378
>NP_714928
          Length = 992

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   FLAQAQP 9
           FLA+AQP
Sbjct: 473 FLAEAQP 479
>XP_005248009
          Length = 535

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   FLAQAQP 9
           FLA+AQP
Sbjct: 473 FLAEAQP 479
>XP_006713930
          Length = 772

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   FLAQAQP 9
           FLA+AQP
Sbjct: 473 FLAEAQP 479
>XP_006713929
          Length = 930

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   FLAQAQP 9
           FLA+AQP
Sbjct: 473 FLAEAQP 479
>XP_006713928
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   FLAQAQP 9
           FLA+AQP
Sbjct: 473 FLAEAQP 479
>NP_060142
          Length = 1865

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 578 NHFIKTAQP 586
>NP_005985
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SHFLAQAQP 9
          S FLA AQP
Sbjct: 27 SAFLAAAQP 35
>XP_006720645
          Length = 1060

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 578 NHFIKTAQP 586
>XP_005254546
          Length = 1443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 136 NHFIKTAQP 144
>XP_005254545
          Length = 1864

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 578 NHFIKTAQP 586
>XP_005254544
          Length = 1884

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 578 NHFIKTAQP 586
>XP_005254543
          Length = 1885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SHFLAQAQP 9
           +HF+  AQP
Sbjct: 578 NHFIKTAQP 586
>NP_001640
          Length = 1616

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/10 (80%), Positives = 8/10 (80%), Gaps = 2/10 (20%)

Query: 2   HF--LAQAQP 9
           HF  LAQAQP
Sbjct: 348 HFTALAQAQP 357
>XP_005274557
          Length = 1615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 8/10 (80%), Positives = 8/10 (80%), Gaps = 2/10 (20%)

Query: 2   HF--LAQAQP 9
           HF  LAQAQP
Sbjct: 348 HFTALAQAQP 357
>NP_114431
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 277 HFIAQA 282
>NP_001156889
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 231 HFIAQA 236
>NP_001156890
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 167 HFIAQA 172
>NP_002438
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SHFLAQAQ 8
            +HFLAQ +
Sbjct: 1297 THFLAQGR 1304
>NP_001231866
          Length = 1351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SHFLAQAQ 8
            +HFLAQ +
Sbjct: 1248 THFLAQGR 1255
>NP_060103
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SHFLAQAQP 9
           ++++AQ QP
Sbjct: 418 NYYIAQVQP 426
>XP_005272167
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 158 HFIAQA 163
>XP_005272166
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 277 HFIAQA 282
>XP_006714782
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 194 HFIAQA 199
>XP_006714781
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 194 HFIAQA 199
>XP_005272165
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 194 HFIAQA 199
>XP_005272164
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 277 HFIAQA 282
>XP_005272163
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 204 HFIAQA 209
>XP_005272162
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 213 HFIAQA 218
>XP_005272161
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 231 HFIAQA 236
>XP_005272160
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 277 HFIAQA 282
>XP_006714780
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           HF+AQA
Sbjct: 277 HFIAQA 282
>XP_005265227
          Length = 1401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    SHFLAQAQ 8
            +HFLAQ +
Sbjct: 1298 THFLAQGR 1305
>NP_116165
          Length = 2540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 843 HLLGQAHP 850
>NP_001269877
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 661 HLLGQAHP 668
>NP_055737
          Length = 1429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           H+LAQA
Sbjct: 553 HYLAQA 558
>NP_001028225
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           H+LAQA
Sbjct: 553 HYLAQA 558
>NP_207646
          Length = 2572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    HFLAQAQP 9
            HFL   QP
Sbjct: 1791 HFLPSLQP 1798
>NP_127497
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           H+LAQA
Sbjct: 553 HYLAQA 558
>NP_127500
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           H+LAQA
Sbjct: 553 HYLAQA 558
>NP_061852
          Length = 2382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 822 AHFLPVGQP 830
>NP_127499
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HFLAQA 7
           H+LAQA
Sbjct: 553 HYLAQA 558
>NP_777603
          Length = 122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  SHFLAQA 7
          SH+ AQA
Sbjct: 33 SHYFAQA 39
>NP_001229725
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   SHFLAQAQP 9
           SHF    QP
Sbjct: 328 SHFTVNQQP 336
>NP_001229724
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   SHFLAQAQP 9
           SHF    QP
Sbjct: 328 SHFTVNQQP 336
>NP_055484
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   SHFLAQAQP 9
           SHF    QP
Sbjct: 451 SHFTVNQQP 459
>NP_001167449
          Length = 92

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1 SHFLAQA 7
         SH+ AQA
Sbjct: 3 SHYFAQA 9
>XP_005256320
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1   SHFLAQAQP 9
           SHF    QP
Sbjct: 451 SHFTVNQQP 459
>XP_006720345
          Length = 1522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           HFL   QP
Sbjct: 741 HFLPSLQP 748
>XP_005268192
          Length = 1602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           HFL   QP
Sbjct: 821 HFLPSLQP 828
>XP_005268191
          Length = 2572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2    HFLAQAQP 9
            HFL   QP
Sbjct: 1791 HFLPSLQP 1798
>XP_006719066
          Length = 2381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 821 AHFLPVGQP 829
>XP_005253800
          Length = 2013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 415 AHFLPVGQP 423
>XP_005253795
          Length = 2280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 822 AHFLPVGQP 830
>XP_005253794
          Length = 2391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 793 AHFLPVGQP 801
>XP_005253793
          Length = 2392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 794 AHFLPVGQP 802
>XP_005253792
          Length = 2419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 822 AHFLPVGQP 830
>XP_006719061
          Length = 2419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 821 AHFLPVGQP 829
>XP_005253791
          Length = 2420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SHFLAQAQP 9
           +HFL   QP
Sbjct: 822 AHFLPVGQP 830
>XP_005269685
          Length = 1700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 843 HLLGQAHP 850
>XP_005269684
          Length = 2032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 843 HLLGQAHP 850
>XP_005269683
          Length = 2252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 555 HLLGQAHP 562
>XP_005269681
          Length = 2321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 624 HLLGQAHP 631
>XP_006717770
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 661 HLLGQAHP 668
>XP_005269679
          Length = 2502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   HFLAQAQP 9
           H L QA P
Sbjct: 805 HLLGQAHP 812
>NP_005693
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  HFLAQAQP 9
          HFL  +QP
Sbjct: 72 HFLGFSQP 79
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.124    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,750
Number of extensions: 894
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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