Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1135
XP_006716142                                                           18    1135
XP_005250088                                                           18    1135
XP_006716141                                                           18    1135
XP_005250085                                                           18    1135
XP_006716140                                                           18    1135
XP_005250084                                                           18    1135
XP_005250083                                                           18    1135
XP_005250082                                                           18    1135
NP_001001670                                                           16    7355
NP_997299                                                              16    7355
NP_001138669                                                           16    7355
XP_005276416                                                           16    7355
NP_036427                                                              15    9605
NP_001186210                                                           15    9605
XP_006724247                                                           15    9605
XP_006724246                                                           15    9605
XP_006724245                                                           15    9605
XP_006724244                                                           15    9605
XP_006724243                                                           15    9605
XP_005261477                                                           15    9605
XP_005261476                                                           15    9605
XP_005261474                                                           15    9605
XP_006724242                                                           15    9605
XP_005261473                                                           15    9605
XP_005261472                                                           15    9605

>NP_733751
          Length = 4911

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4184 SHGIAESAA 4192



>XP_006716142
          Length = 4927

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4200 SHGIAESAA 4208



>XP_005250088
          Length = 4928

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4201 SHGIAESAA 4209



>XP_006716141
          Length = 4959

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4232 SHGIAESAA 4240



>XP_005250085
          Length = 4979

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4256 SHGIAESAA 4264



>XP_006716140
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4255 SHGIAESAA 4263



>XP_005250084
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4255 SHGIAESAA 4263



>XP_005250083
          Length = 4982

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4255 SHGIAESAA 4263



>XP_005250082
          Length = 4983

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SHDIAESAA 9
            SH IAESAA
Sbjct: 4256 SHGIAESAA 4264



>NP_001001670
          Length = 1576

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HDIAES 7
           HD+AES
Sbjct: 462 HDLAES 467



>NP_997299
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HDIAES 7
           HD+AES
Sbjct: 459 HDLAES 464



>NP_001138669
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HDIAES 7
           HD+AES
Sbjct: 459 HDLAES 464



>XP_005276416
          Length = 1583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HDIAES 7
           HD+AES
Sbjct: 448 HDLAES 453



>NP_036427
          Length = 2220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>NP_001186210
          Length = 2220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724247
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724246
          Length = 2103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724245
          Length = 2191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724244
          Length = 2191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724243
          Length = 2196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_005261477
          Length = 2200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_005261476
          Length = 2210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 179 HDVSVSAA 186



>XP_005261474
          Length = 2225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_006724242
          Length = 2226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_005261473
          Length = 2250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



>XP_005261472
          Length = 2255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HDIAESAA 9
           HD++ SAA
Sbjct: 224 HDVSVSAA 231



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.105    0.257 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 345,843
Number of extensions: 283
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)