Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001253990                                                           18    1482
NP_055563                                                              18    1482
NP_001253988                                                           18    1935
NP_852002                                                              18    1935
NP_001156956                                                           18    1935
NP_079506                                                              18    1935
NP_001150                                                              17    4312
NP_065935                                                              17    4312
NP_001275743                                                           17    4312
NP_115826                                                              17    4312
XP_006723903                                                           17    4312
XP_006723902                                                           17    4312
XP_006716698                                                           17    4312
XP_006716696                                                           17    4312
XP_006716695                                                           17    4312
XP_006716694                                                           17    4312
XP_006716693                                                           17    4312
XP_006716692                                                           17    4312
XP_006716691                                                           17    4312
XP_006716690                                                           17    4312
XP_006716689                                                           17    4312
NP_004706                                                              16    5631
NP_001189433                                                           16    5631
NP_430255                                                              16    5631
NP_006006                                                              16    5631
NP_624361                                                              16    5631
NP_001177848                                                           16    5631
NP_001177847                                                           16    5631
NP_003241                                                              16    5631
XP_006722637                                                           16    5631
XP_005266839                                                           16    5631
NP_036400                                                              16    7355
NP_001278240                                                           16    7355
NP_001026866                                                           16    7355
NP_001025178                                                           16    7355
NP_001119                                                              16    7355
XP_005258767                                                           16    7355
XP_005258766                                                           16    7355
XP_005258765                                                           16    7355
XP_006723187                                                           16    7355
XP_005258763                                                           16    7355
XP_005258764                                                           16    7355
XP_006723186                                                           16    7355
XP_005258762                                                           16    7355
XP_006723185                                                           16    7355
XP_006723184                                                           16    7355
XP_005258761                                                           16    7355
NP_000050                                                              15    9605
NP_003211                                                              15    9605
NP_001027451                                                           15    9605
NP_001035890                                                           15    9605
NP_777577                                                              15    9605
NP_001230208                                                           15    9605
NP_001120686                                                           15    9605
NP_000122                                                              15    9605
NP_062562                                                              15    9605
XP_006721229                                                           15    9605
XP_005256350                                                           15    9605
XP_006720026                                                           15    9605
XP_006715238                                                           15    9605
>NP_001253990
          Length = 450

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGVLHTRIR 9
          +GVLH R+R
Sbjct: 8  NGVLHCRVR 16
>NP_055563
          Length = 470

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGVLHTRIR 9
          +GVLH R+R
Sbjct: 28 NGVLHCRVR 36
>NP_001253988
          Length = 458

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGVLHTRIR 9
          +GVLH R+R
Sbjct: 28 NGVLHCRLR 36
>NP_852002
          Length = 520

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           GVLHT IR
Sbjct: 409 GVLHTLIR 416
>NP_001156956
          Length = 546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           GVLHT IR
Sbjct: 435 GVLHTLIR 442
>NP_079506
          Length = 546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           GVLHT IR
Sbjct: 435 GVLHTLIR 442
>NP_001150
          Length = 1338

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    GVLHTR 7
            G+LHTR
Sbjct: 1226 GILHTR 1231
>NP_065935
          Length = 1983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           G+LH R+R
Sbjct: 443 GLLHPRVR 450
>NP_001275743
          Length = 1632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1436 SGLLHVAIR 1444
>NP_115826
          Length = 1641

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1445 SGLLHVAIR 1453
>XP_006723903
          Length = 1989

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           G+LH R+R
Sbjct: 443 GLLHPRVR 450
>XP_006723902
          Length = 1787

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVLHTRIR 9
           G+LH R+R
Sbjct: 241 GLLHPRVR 248
>XP_006716698
          Length = 1481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1445 SGLLHVAIR 1453
>XP_006716696
          Length = 1585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1377 SGLLHVAIR 1385
>XP_006716695
          Length = 1585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1377 SGLLHVAIR 1385
>XP_006716694
          Length = 1632

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1436 SGLLHVAIR 1444
>XP_006716693
          Length = 1644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1436 SGLLHVAIR 1444
>XP_006716692
          Length = 1644

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1436 SGLLHVAIR 1444
>XP_006716691
          Length = 1653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1445 SGLLHVAIR 1453
>XP_006716690
          Length = 1653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1445 SGLLHVAIR 1453
>XP_006716689
          Length = 1653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SGVLHTRIR 9
            SG+LH  IR
Sbjct: 1445 SGLLHVAIR 1453
>NP_004706
          Length = 961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLHTRIR 9
           +LHTR+R
Sbjct: 220 MLHTRLR 226
>NP_001189433
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLHTRIR 9
           +LHTR+R
Sbjct: 101 MLHTRLR 107
>NP_430255
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLHTRIR 9
           +LHTR+R
Sbjct: 220 MLHTRLR 226
>NP_006006
          Length = 2285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SGVLHTRI 8
            SG+LH RI
Sbjct: 1839 SGLLHWRI 1846
>NP_624361
          Length = 2068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SGVLHTRI 8
            SG+LH RI
Sbjct: 1622 SGLLHWRI 1629
>NP_001177848
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGVLHTR 7
           SG+LH R
Sbjct: 450 SGILHAR 456
>NP_001177847
          Length = 451

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGVLHTR 7
           SG+LH R
Sbjct: 411 SGILHAR 417
>NP_003241
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGVLHTR 7
           SG+LH R
Sbjct: 450 SGILHAR 456
>XP_006722637
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLHTRIR 9
           +LHTR+R
Sbjct: 119 MLHTRLR 125
>XP_005266839
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VLHTRIR 9
           +LHTR+R
Sbjct: 220 MLHTRLR 226
>NP_036400
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>NP_001278240
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>NP_001026866
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>NP_001025178
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVLHTRI 8
           GVLHT +
Sbjct: 189 GVLHTSV 195
>NP_001119
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GVLHTRI 8
           GVLHT +
Sbjct: 189 GVLHTSV 195
>XP_005258767
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258766
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258765
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_006723187
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258763
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258764
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_006723186
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258762
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_006723185
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_006723184
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>XP_005258761
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GVLHTR 7
           GVLHT+
Sbjct: 198 GVLHTK 203
>NP_000050
          Length = 3418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SGVLHTRIR 9
           SG+LH+ ++
Sbjct: 636 SGLLHSSVK 644
>NP_003211
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGVLHT 6
           SG+LHT
Sbjct: 105 SGLLHT 110
>NP_001027451
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGVLHT 6
           SG+LHT
Sbjct: 99  SGLLHT 104
>NP_001035890
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGVLHT 6
           SG+LHT
Sbjct: 101 SGLLHT 106
>NP_777577
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGVLHT 6
          SG+LHT
Sbjct: 29 SGLLHT 34
>NP_001230208
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGVLHT 6
          SG+LHT
Sbjct: 29 SGLLHT 34
>NP_001120686
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGVLHT 6
          SG+LHT
Sbjct: 29 SGLLHT 34
>NP_000122
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GVLHTRIR 9
          GVLH R R
Sbjct: 53 GVLHRRRR 60
>NP_062562
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GVLHTRIR 9
          GVLH R R
Sbjct: 31 GVLHRRRR 38
>XP_006721229
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGVLHT 6
          SG+LHT
Sbjct: 29 SGLLHT 34
>XP_005256350
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGVLHT 6
          SG+LHT
Sbjct: 29 SGLLHT 34
>XP_006720026
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GVLHTRIR 9
          GVLH R R
Sbjct: 31 GVLHRRRR 38
>XP_006715238
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGVLHT 6
           SG+LHT
Sbjct: 150 SGLLHT 155
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.142    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 677,185
Number of extensions: 1009
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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