Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
NP_055296                                                              18    1935
XP_005265948                                                           17    3301
NP_065768                                                              16    5631
XP_006724654                                                           16    5631
XP_006724653                                                           16    5631
NP_001161328                                                           16    7355
NP_060653                                                              16    7355
NP_919226                                                              16    7355
NP_001240756                                                           16    7355
NP_291025                                                              16    7355
XP_005253633                                                           16    7355
XP_005253632                                                           16    7355
XP_006719537                                                           16    7355
XP_006719536                                                           16    7355
XP_005253630                                                           16    7355
XP_005253629                                                           16    7355
NP_060644                                                              16    7355
NP_064630                                                              15    9605
NP_001025054                                                           15    9605
NP_976241                                                              15    9605
NP_998754                                                              15    9605
NP_055917                                                              15    9605
NP_031375                                                              15    9605
NP_001269280                                                           15    9605
NP_001093254                                                           15    9605
XP_005249598                                                           15    9605
XP_005249596                                                           15    9605
XP_005249594                                                           15    9605
XP_005249593                                                           15    9605
XP_005267114                                                           15    9605
XP_005246837                                                           15    9605
XP_005246836                                                           15    9605
XP_006712758                                                           15    9605
XP_005246834                                                           15    9605
XP_006710633                                                           15    9605
XP_006710632                                                           15    9605
XP_006710631                                                           15    9605
XP_006710630                                                           15    9605
XP_006710629                                                           15    9605
XP_006710628                                                           15    9605
XP_006710627                                                           15    9605
XP_006710626                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           S VANKQPS
Sbjct: 288 SAVANKQPS 296
>NP_055296
          Length = 518

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  GVANKQPS 9
          GVAN++PS
Sbjct: 18 GVANQEPS 25
>XP_005265948
          Length = 273

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VANKQPS 9
           VANKQP+
Sbjct: 183 VANKQPA 189
>NP_065768
          Length = 1493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           S +AN+QPS
Sbjct: 520 SELANQQPS 528
>XP_006724654
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           S +AN+QPS
Sbjct: 362 SELANQQPS 370
>XP_006724653
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           S +AN+QPS
Sbjct: 404 SELANQQPS 412
>NP_001161328
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 807 SGLGSKRPS 815
>NP_060653
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 806 SGLGSKRPS 814
>NP_919226
          Length = 1209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SGVANKQP 8
            SG+ N QP
Sbjct: 996  SGILNTQP 1003
>NP_001240756
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SGVANKQPS 9
          SG+++ QPS
Sbjct: 17 SGLSSSQPS 25
>NP_291025
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SGVANKQ 7
           SGV NKQ
Sbjct: 712 SGVENKQ 718
>XP_005253633
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 806 SGLGSKRPS 814
>XP_005253632
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 806 SGLGSKRPS 814
>XP_006719537
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 807 SGLGSKRPS 815
>XP_006719536
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 807 SGLGSKRPS 815
>XP_005253630
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 807 SGLGSKRPS 815
>XP_005253629
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SG+ +K+PS
Sbjct: 807 SGLGSKRPS 815
>NP_060644
          Length = 1059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVANKQPS 9
           GVA K+P+
Sbjct: 500 GVARKEPA 507
>NP_064630
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    VANKQP 8
            +ANKQP
Sbjct: 1467 MANKQP 1472
>NP_001025054
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  GVANKQPS 9
          G+A +QPS
Sbjct: 56 GLAEEQPS 63
>NP_976241
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 608 SGVSDTQPA 616
>NP_998754
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 556 SGVSDTQPA 564
>NP_055917
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
>NP_031375
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VANKQPS 9
           VAN QPS
Sbjct: 839 VANVQPS 845
>NP_001269280
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SGVANKQP 8
           SGV  +QP
Sbjct: 166 SGVVRRQP 173
>NP_001093254
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SGVANKQP 8
           SGV  +QP
Sbjct: 478 SGVVRRQP 485
>XP_005249598
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VANKQPS 9
           VAN QPS
Sbjct: 792 VANVQPS 798
>XP_005249596
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VANKQPS 9
           VAN QPS
Sbjct: 805 VANVQPS 811
>XP_005249594
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VANKQPS 9
           VAN QPS
Sbjct: 805 VANVQPS 811
>XP_005249593
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VANKQPS 9
           VAN QPS
Sbjct: 839 VANVQPS 845
>XP_005267114
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    VANKQP 8
            +ANKQP
Sbjct: 1467 MANKQP 1472
>XP_005246837
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 583 SGVSDTQPA 591
>XP_005246836
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 608 SGVSDTQPA 616
>XP_006712758
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 608 SGVSDTQPA 616
>XP_005246834
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGVANKQPS 9
           SGV++ QP+
Sbjct: 608 SGVSDTQPA 616
>XP_006710633
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 436 ANKQPA 441
>XP_006710632
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 575 ANKQPA 580
>XP_006710631
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
>XP_006710630
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
>XP_006710629
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 611 ANKQPA 616
>XP_006710628
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
>XP_006710627
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
>XP_006710626
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ANKQPS 9
           ANKQP+
Sbjct: 612 ANKQPA 617
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.109    0.285 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 698,634
Number of extensions: 1314
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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