Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              18    1935
XP_005269721                                                           18    1935
NP_031371                                                              17    3301
XP_005266819                                                           17    3301
XP_006722604                                                           17    3301
NP_003226                                                              17    4312
XP_005251100                                                           17    4312
XP_006716686                                                           17    4312
XP_005251099                                                           17    4312
XP_005251097                                                           17    4312
XP_005251095                                                           17    4312
XP_006716685                                                           17    4312
XP_005276293                                                           16    5631
XP_005264833                                                           16    5631
XP_005276006                                                           16    5631
NP_116250                                                              16    7355
NP_112210                                                              16    7355
NP_001229577                                                           16    7355
NP_001245207                                                           16    7355
NP_001245205                                                           16    7355
NP_001245206                                                           16    7355
XP_006715649                                                           16    7355
XP_006715648                                                           16    7355
XP_005266874                                                           16    7355
XP_005266873                                                           16    7355
XP_005248994                                                           16    7355
XP_005248993                                                           16    7355
XP_005248992                                                           16    7355
XP_005248990                                                           16    7355
XP_005248991                                                           16    7355
XP_006715084                                                           16    7355
NP_443145                                                              16    7355
NP_001248344                                                           15    9605
NP_694534                                                              15    9605
NP_008871                                                              15    9605
NP_001248343                                                           15    9605
NP_001137236                                                           15    9605
NP_001137235                                                           15    9605
XP_006719213                                                           15    9605
XP_006719212                                                           15    9605
NP_002999                                                              15    9605
>NP_036462
          Length = 2073

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           SGQS SSQK
Sbjct: 501 SGQSPSSQK 509
>XP_005269721
          Length = 2073

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           SGQS SSQK
Sbjct: 501 SGQSPSSQK 509
>NP_031371
          Length = 1845

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SGQSLSSQK 9
            +G SLSSQK
Sbjct: 1710 AGPSLSSQK 1718
>XP_005266819
          Length = 1790

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SGQSLSSQK 9
            +G SLSSQK
Sbjct: 1655 AGPSLSSQK 1663
>XP_006722604
          Length = 1847

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    SGQSLSSQK 9
            +G SLSSQK
Sbjct: 1712 AGPSLSSQK 1720
>NP_003226
          Length = 2768

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_005251100
          Length = 2103

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_006716686
          Length = 2111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_005251099
          Length = 2121

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_005251097
          Length = 2178

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_005251095
          Length = 2704

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1806 QSLSSQK 1812
>XP_006716685
          Length = 2747

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    QSLSSQK 9
            QSLSSQK
Sbjct: 1870 QSLSSQK 1876
>XP_005276293
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SGQSLSSQK 9
           SGQ LSS K
Sbjct: 369 SGQLLSSSK 377
>XP_005264833
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SGQSLSSQK 9
           SGQ LSS K
Sbjct: 369 SGQLLSSSK 377
>XP_005276006
          Length = 695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SGQSLSSQK 9
           SGQ LSS K
Sbjct: 369 SGQLLSSSK 377
>NP_116250
          Length = 654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           S QSL++QK
Sbjct: 238 SSQSLAAQK 246
>NP_112210
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 180 NGQSLSSSQ 188
>NP_001229577
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 180 NGQSLSSSQ 188
>NP_001245207
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>NP_001245205
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>NP_001245206
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>XP_006715649
          Length = 584

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           S QSL++QK
Sbjct: 168 SSQSLAAQK 176
>XP_006715648
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           S QSL++QK
Sbjct: 238 SSQSLAAQK 246
>XP_005266874
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>XP_005266873
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>XP_005248994
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGQSLSSQK 9
          +GQSLSS +
Sbjct: 88 NGQSLSSSQ 96
>XP_005248993
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGQSLSSQK 9
          +GQSLSS +
Sbjct: 88 NGQSLSSSQ 96
>XP_005248992
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 180 NGQSLSSSQ 188
>XP_005248990
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 180 NGQSLSSSQ 188
>XP_005248991
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 180 NGQSLSSSQ 188
>XP_006715084
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGQSLSSQK 9
           +GQSLSS +
Sbjct: 181 NGQSLSSSQ 189
>NP_443145
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   GQSLSSQ 8
           G+SLSSQ
Sbjct: 352 GESLSSQ 358
>NP_001248344
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 110 SGESLSS 116
>NP_694534
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 107 SGESLSS 113
>NP_008871
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 120 SGESLSS 126
>NP_001248343
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 107 SGESLSS 113
>NP_001137236
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GQSLSSQK 9
          GQ  SSQK
Sbjct: 25 GQDTSSQK 32
>NP_001137235
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GQSLSSQK 9
          GQ  SSQK
Sbjct: 25 GQDTSSQK 32
>XP_006719213
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 107 SGESLSS 113
>XP_006719212
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGQSLSS 7
           SG+SLSS
Sbjct: 107 SGESLSS 113
>NP_002999
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGQSLSSQ 8
           SG+ LSSQ
Sbjct: 151 SGKGLSSQ 158
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.277   0.0947    0.205 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 406,964
Number of extensions: 678
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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