Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              18    1135
XP_006714104                                                           18    1135
XP_005265800                                                           18    1135
XP_006714103                                                           18    1135
XP_006714102                                                           18    1135
NP_066925                                                              18    1935
NP_001159575                                                           18    1935
NP_004229                                                              17    4312
NP_001271144                                                           17    4312
NP_001271143                                                           17    4312
NP_001271145                                                           17    4312
XP_006712916                                                           17    4312
XP_005247020                                                           17    4312
XP_005247019                                                           17    4312
XP_006712915                                                           17    4312
XP_005247018                                                           17    4312
XP_005247017                                                           17    4312
XP_005247015                                                           17    4312
XP_005247014                                                           17    4312
XP_005247013                                                           17    4312
XP_005247012                                                           17    4312
XP_005247011                                                           17    4312
NP_001161820                                                           16    5631
NP_001161819                                                           16    5631
NP_683759                                                              16    5631
NP_060514                                                              16    5631
NP_002045                                                              16    5631
NP_056382                                                              16    5631
XP_005254096                                                           16    5631
XP_005254095                                                           16    5631
NP_619642                                                              16    7355
NP_803884                                                              16    7355
NP_000889                                                              16    7355
XP_005272665                                                           16    7355
XP_005272664                                                           16    7355
NP_543009                                                              15    9605
NP_001072980                                                           15    9605
NP_071379                                                              15    9605
XP_005260849                                                           15    9605
XP_006721007                                                           15    9605
XP_005255620                                                           15    9605
NP_942093                                                              15    9605
>NP_006197
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SGLFVMVLE 9
          SGLFV VLE
Sbjct: 78 SGLFVTVLE 86
>XP_006714104
          Length = 832

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGLFVMVLE 9
           SGLFV VLE
Sbjct: 103 SGLFVTVLE 111
>XP_005265800
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  SGLFVMVLE 9
          SGLFV VLE
Sbjct: 78 SGLFVTVLE 86
>XP_006714103
          Length = 1111

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGLFVMVLE 9
           SGLFV VLE
Sbjct: 100 SGLFVTVLE 108
>XP_006714102
          Length = 1114

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGLFVMVLE 9
           SGLFV VLE
Sbjct: 103 SGLFVTVLE 111
>NP_066925
          Length = 252

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           +GLFVMVL
Sbjct: 202 AGLFVMVL 209
>NP_001159575
          Length = 195

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           +GLFVMVL
Sbjct: 145 AGLFVMVL 152
>NP_004229
          Length = 1992

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 665 SGMFIMVV 672
>NP_001271144
          Length = 2025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 671 SGMFIMVV 678
>NP_001271143
          Length = 2040

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>NP_001271145
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 368 SGMFIMVV 375
>XP_006712916
          Length = 1998

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 671 SGMFIMVV 678
>XP_005247020
          Length = 2013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>XP_005247019
          Length = 2025

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 671 SGMFIMVV 678
>XP_006712915
          Length = 2026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 671 SGMFIMVV 678
>XP_005247018
          Length = 2026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 671 SGMFIMVV 678
>XP_005247017
          Length = 2039

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 684 SGMFIMVV 691
>XP_005247015
          Length = 2041

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>XP_005247014
          Length = 2063

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>XP_005247013
          Length = 2067

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>XP_005247012
          Length = 2068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>XP_005247011
          Length = 2068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SGLFVMVL 8
           SG+F+MV+
Sbjct: 713 SGMFIMVV 720
>NP_001161820
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLFVMVLE 9
           SG FV V+E
Sbjct: 377 SGFFVAVIE 385
>NP_001161819
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLFVMVLE 9
           SG FV V+E
Sbjct: 415 SGFFVAVIE 423
>NP_683759
          Length = 466

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLFVMVLE 9
           SG FV V+E
Sbjct: 415 SGFFVAVIE 423
>NP_060514
          Length = 429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLFVMVLE 9
           SG FV V+E
Sbjct: 415 SGFFVAVIE 423
>NP_002045
          Length = 180

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  SGLFVMVLE 9
          +GLFVM+++
Sbjct: 8  AGLFVMLVQ 16
>NP_056382
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLFVMVLE 9
           +GLFV+V++
Sbjct: 682 AGLFVLVMK 690
>XP_005254096
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLFVMVLE 9
           +GLFV+V++
Sbjct: 682 AGLFVLVMK 690
>XP_005254095
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLFVMVLE 9
           +GLFV+V++
Sbjct: 682 AGLFVLVMK 690
>NP_619642
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SGLFVMV 7
           +GLFVM+
Sbjct: 679 AGLFVMI 685
>NP_803884
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SGLFVMV 7
           +GLFVM+
Sbjct: 425 AGLFVMI 431
>NP_000889
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SGLFVMVLE 9
          SGL V+VLE
Sbjct: 26 SGLNVVVLE 34
>XP_005272665
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SGLFVMVLE 9
          SGL V+VLE
Sbjct: 10 SGLNVVVLE 18
>XP_005272664
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  SGLFVMVLE 9
          SGL V+VLE
Sbjct: 10 SGLNVVVLE 18
>NP_543009
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGLFVMVL 8
          +GL VMVL
Sbjct: 9  AGLLVMVL 16
>NP_001072980
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GLFVMVL 8
          G FVMVL
Sbjct: 61 GCFVMVL 67
>NP_071379
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVMVLE 9
           FVMVLE
Sbjct: 359 FVMVLE 364
>XP_005260849
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVMVLE 9
           FVMVLE
Sbjct: 170 FVMVLE 175
>XP_006721007
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GLFVMVL 8
          G FVMVL
Sbjct: 61 GCFVMVL 67
>XP_005255620
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GLFVMVL 8
          G FVMVL
Sbjct: 61 GCFVMVL 67
>NP_942093
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVMVLE 9
           FVMVLE
Sbjct: 359 FVMVLE 364
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.150    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 319,750
Number of extensions: 337
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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