Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_919047                                                              18    1482
XP_005250598                                                           18    1482
NP_001128144                                                           17    3301
NP_071346                                                              17    3301
XP_006718002                                                           17    3301
XP_005270081                                                           17    3301
NP_004514                                                              16    5631
NP_001495                                                              16    7355
NP_001136269                                                           16    7355
NP_001157790                                                           16    7355
NP_001034456                                                           16    7355
NP_001034455                                                           16    7355
NP_001687                                                              16    7355
NP_001157791                                                           16    7355
NP_001157789                                                           16    7355
NP_878267                                                              16    7355
NP_001448                                                              16    7355
NP_542384                                                              16    7355
XP_005262313                                                           16    7355
XP_005272199                                                           16    7355
XP_006713130                                                           16    7355
XP_005265039                                                           16    7355
XP_005265038                                                           16    7355
XP_005265035                                                           16    7355
XP_005265034                                                           16    7355
XP_005246728                                                           16    7355
XP_005264691                                                           16    7355
XP_005264690                                                           16    7355
NP_000382                                                              15    9605
NP_001092740                                                           15    9605
NP_037498                                                              15    9605
NP_002239                                                              15    9605
NP_001127666                                                           15    9605
NP_008949                                                              15    9605
NP_001090                                                              15    9605
XP_005259964                                                           15    9605
XP_005259963                                                           15    9605
XP_005259962                                                           15    9605
XP_006717396                                                           15    9605
XP_006717395                                                           15    9605
XP_005252375                                                           15    9605
XP_006717394                                                           15    9605
XP_006717393                                                           15    9605
XP_006717391                                                           15    9605
XP_006717390                                                           15    9605
XP_005252046                                                           15    9605
XP_006717007                                                           15    9605
XP_006717005                                                           15    9605
XP_006717004                                                           15    9605
XP_006717003                                                           15    9605
XP_005251736                                                           15    9605
>NP_919047
          Length = 520

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGLESRLDV 9
           SGLESR DV
Sbjct: 463 SGLESRPDV 471
>XP_005250598
          Length = 457

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGLESRLDV 9
           SGLESR DV
Sbjct: 400 SGLESRPDV 408
>NP_001128144
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGLESRLD 8
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>NP_071346
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGLESRLD 8
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>XP_006718002
          Length = 233

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGLESRLD 8
           SGLE R+D
Sbjct: 152 SGLEKRID 159
>XP_005270081
          Length = 240

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGLESRLD 8
           SGLE R+D
Sbjct: 159 SGLEKRID 166
>NP_004514
          Length = 1056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGLESRLD 8
           SGL S+LD
Sbjct: 511 SGLHSKLD 518
>NP_001495
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GLESRLDV 9
           G ESR+DV
Sbjct: 291 GRESRVDV 298
>NP_001136269
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GLESRLDV 9
           G ESR+DV
Sbjct: 338 GRESRVDV 345
>NP_001157790
          Length = 2591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>NP_001034456
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 166 LESRLDL 172
>NP_001034455
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 174 LESRLDL 180
>NP_001687
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 196 LESRLDL 202
>NP_001157791
          Length = 2578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>NP_001157789
          Length = 2633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>NP_878267
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLESRLDV 9
           SGLE  LD+
Sbjct: 349 SGLEIMLDI 357
>NP_001448
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>NP_542384
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 196 LESRLDL 202
>XP_005262313
          Length = 378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GLESRLDV 9
           G ESR+DV
Sbjct: 301 GRESRVDV 308
>XP_005272199
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GLESRLDV 9
           G+ES++DV
Sbjct: 866 GIESQVDV 873
>XP_006713130
          Length = 2109

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>XP_005265039
          Length = 2177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>XP_005265038
          Length = 2181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>XP_005265035
          Length = 2609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>XP_005265034
          Length = 2622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SGLESRLDV 9
           +GLE+R++V
Sbjct: 950 NGLENRVEV 958
>XP_005246728
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLESRLDV 9
           SGLE  LD+
Sbjct: 222 SGLEIMLDI 230
>XP_005264691
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 196 LESRLDL 202
>XP_005264690
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LESRLDV 9
           LESRLD+
Sbjct: 196 LESRLDL 202
>NP_000382
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGLESRLDV 9
           +G+E+ LDV
Sbjct: 269 AGIEASLDV 277
>NP_001092740
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   GLESRLDV 9
           GL+SR+++
Sbjct: 485 GLDSRMEI 492
>NP_037498
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 118 LESRLD 123
>NP_002239
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 485 LESRLD 490
>NP_001127666
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLESRLDV 9
           SGL+  LDV
Sbjct: 294 SGLQMALDV 302
>NP_008949
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 574 LESRLD 579
>NP_001090
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGLESRLDV 9
           SGL+  LDV
Sbjct: 294 SGLQMALDV 302
>XP_005259964
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 565 LESRLD 570
>XP_005259963
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 568 LESRLD 573
>XP_005259962
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 571 LESRLD 576
>XP_006717396
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 354 SGLESR 359
>XP_006717395
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 382 SGLESR 387
>XP_005252375
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717394
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 395 SGLESR 400
>XP_006717393
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717391
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 412 SGLESR 417
>XP_006717390
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SGLESR 6
           SGLESR
Sbjct: 412 SGLESR 417
>XP_005252046
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   GLESRLDV 9
           GL+SR+++
Sbjct: 499 GLDSRMEI 506
>XP_006717007
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717005
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LESRLD 8
          LESRLD
Sbjct: 22 LESRLD 27
>XP_006717004
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 574 LESRLD 579
>XP_006717003
          Length = 2278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 574 LESRLD 579
>XP_005251736
          Length = 2325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LESRLD 8
           LESRLD
Sbjct: 574 LESRLD 579
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.132    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 444,612
Number of extensions: 726
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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