Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1482
XP_006716142                                                           18    1482
XP_005250088                                                           18    1482
XP_006716141                                                           18    1482
XP_005250085                                                           18    1482
XP_006716140                                                           18    1482
XP_005250084                                                           18    1482
XP_005250083                                                           18    1482
XP_005250082                                                           18    1482
NP_065850                                                              17    3301
XP_006717993                                                           17    3301
XP_006717992                                                           17    3301
XP_006717991                                                           17    3301
NP_998814                                                              17    4312
XP_005269584                                                           17    4312
XP_005269583                                                           17    4312
XP_006717688                                                           17    4312
XP_005269582                                                           17    4312
NP_001164269                                                           17    4312
NP_055412                                                              16    5631
XP_006715622                                                           16    5631
XP_005267190                                                           16    5631
XP_005267189                                                           16    5631
XP_005267187                                                           16    5631
XP_005267185                                                           16    5631
XP_005267184                                                           16    5631
NP_009055                                                              16    5631
NP_775835                                                              16    7355
XP_005250285                                                           16    7355
XP_006715971                                                           16    7355
XP_006715970                                                           16    7355
NP_821075                                                              15    9605
NP_443083                                                              15    9605
NP_821074                                                              15    9605
NP_001230405                                                           15    9605
NP_001263256                                                           15    9605
NP_001263255                                                           15    9605
NP_700357                                                              15    9605
NP_653186                                                              15    9605
NP_073744                                                              15    9605
NP_001030611                                                           15    9605
NP_061146                                                              15    9605
NP_001136438                                                           15    9605
NP_277039                                                              15    9605
NP_001008781                                                           15    9605
NP_065748                                                              15    9605
NP_954872                                                              15    9605
XP_006722610                                                           15    9605
XP_006719952                                                           15    9605
XP_006719951                                                           15    9605
XP_005266643                                                           15    9605
XP_006718827                                                           15    9605
XP_006718494                                                           15    9605
XP_005273799                                                           15    9605
XP_006718493                                                           15    9605
XP_005252192                                                           15    9605
XP_005270465                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 914 SGIGAVVLP 922
>XP_006716142
          Length = 4927

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_005250088
          Length = 4928

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_006716141
          Length = 4959

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_005250085
          Length = 4979

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_006716140
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_005250084
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>XP_005250083
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 914 SGIGAVVLP 922
>XP_005250082
          Length = 4983

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGI AVVLP
Sbjct: 915 SGIGAVVLP 923
>NP_065850
          Length = 436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GIRAVVLP 9
           G+R VVLP
Sbjct: 265 GLRCVVLP 272
>XP_006717993
          Length = 436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GIRAVVLP 9
           G+R VVLP
Sbjct: 265 GLRCVVLP 272
>XP_006717992
          Length = 436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GIRAVVLP 9
           G+R VVLP
Sbjct: 265 GLRCVVLP 272
>XP_006717991
          Length = 436

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GIRAVVLP 9
           G+R VVLP
Sbjct: 265 GLRCVVLP 272
>NP_998814
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GIRAVVLP 9
           GI++V+LP
Sbjct: 130 GIKSVILP 137
>XP_005269584
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  GIRAVVLP 9
          GI++V+LP
Sbjct: 14 GIKSVILP 21
>XP_005269583
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  GIRAVVLP 9
          GI++V+LP
Sbjct: 14 GIKSVILP 21
>XP_006717688
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GIRAVVLP 9
           GI++V+LP
Sbjct: 130 GIKSVILP 137
>XP_005269582
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GIRAVVLP 9
           GI++V+LP
Sbjct: 121 GIKSVILP 128
>NP_001164269
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GIRAVVLP 9
           G+RA+V P
Sbjct: 168 GVRAIVCP 175
>NP_055412
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGIRAVVLP 9
           SGI  +VLP
Sbjct: 148 SGISRIVLP 156
>XP_006715622
          Length = 2499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SGIR+ +LP
Sbjct: 927 SGIRSSLLP 935
>XP_005267190
          Length = 3424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1852 SGIRSSLLP 1860
>XP_005267189
          Length = 3425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1866 SGIRSSLLP 1874
>XP_005267187
          Length = 3433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1861 SGIRSSLLP 1869
>XP_005267185
          Length = 3437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1865 SGIRSSLLP 1873
>XP_005267184
          Length = 3438

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1866 SGIRSSLLP 1874
>NP_009055
          Length = 3433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SGIRAVVLP 9
            SGIR+ +LP
Sbjct: 1861 SGIRSSLLP 1869
>NP_775835
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R VVL
Sbjct: 734 SGVRQVVL 741
>XP_005250285
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R VVL
Sbjct: 735 SGVRQVVL 742
>XP_006715971
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R VVL
Sbjct: 735 SGVRQVVL 742
>XP_006715970
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R VVL
Sbjct: 735 SGVRQVVL 742
>NP_821075
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GIRAVVL 8
            G+RAVV+
Sbjct: 1036 GVRAVVM 1042
>NP_443083
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GIRAVVL 8
           G+RAVV+
Sbjct: 926 GVRAVVM 932
>NP_821074
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GIRAVVL 8
            G+RAVV+
Sbjct: 1044 GVRAVVM 1050
>NP_001230405
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GIRAVVL 8
            G+RAVV+
Sbjct: 1009 GVRAVVM 1015
>NP_001263256
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 400 SGLAALLLP 408
>NP_001263255
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 474 SGLAALLLP 482
>NP_700357
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 287 SGLAALLLP 295
>NP_653186
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 508 SGLAALLLP 516
>NP_073744
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGIRAVVLP 9
           S IRA +LP
Sbjct: 321 SKIRAFILP 329
>NP_001030611
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGIRAVVLP 9
           S IRA +LP
Sbjct: 308 SKIRAFILP 316
>NP_061146
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SGIRAVVLP 9
           SG+   VLP
Sbjct: 254 SGVEVTVLP 262
>NP_001136438
          Length = 1923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R V+L
Sbjct: 394 SGVRPVIL 401
>NP_277039
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGIRAVVL 8
          SGI A+VL
Sbjct: 74 SGIAAIVL 81
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GIRAVVLP 9
            G+R VV+P
Sbjct: 4134 GLRPVVVP 4141
>NP_065748
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGIRAVVLP 9
           +GI  VVLP
Sbjct: 397 AGILVVVLP 405
>NP_954872
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SGIRAVVLP 9
           SG+   VLP
Sbjct: 254 SGVEVTVLP 262
>XP_006722610
          Length = 1967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGIRAVVL 8
           SG+R V+L
Sbjct: 437 SGVRPVIL 444
>XP_006719952
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GIRAVVL 8
           G+RAVV+
Sbjct: 926 GVRAVVM 932
>XP_006719951
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GIRAVVL 8
           G+RAVV+
Sbjct: 926 GVRAVVM 932
>XP_005266643
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GIRAVVL 8
            G+RAVV+
Sbjct: 1029 GVRAVVM 1035
>XP_006718827
          Length = 3479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GIRAVVLP 9
            G+R VV+P
Sbjct: 3024 GLRPVVVP 3031
>XP_006718494
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 498 SGLAALLLP 506
>XP_005273799
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 533 SGLAALLLP 541
>XP_006718493
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SGIRAVVLP 9
           SG+ A++LP
Sbjct: 533 SGLAALLLP 541
>XP_005252192
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SGIRAVVLP 9
           S IRA +LP
Sbjct: 310 SKIRAFILP 318
>XP_005270465
          Length = 240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGIRAVVL 8
          SGI A+VL
Sbjct: 74 SGIAAIVL 81
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.144    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 375,296
Number of extensions: 662
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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