Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_071756                                                              18    1482
NP_004934                                                              17    3301
NP_002728                                                              17    4312
NP_005364                                                              17    4312
NP_001265225                                                           17    4312
NP_001265224                                                           17    4312
NP_919278                                                              17    4312
XP_006722035                                                           17    4312
XP_006712460                                                           17    4312
XP_006712459                                                           17    4312
NP_055486                                                              16    5631
NP_001728                                                              16    5631
NP_671736                                                              16    5631
NP_004458                                                              16    5631
NP_963847                                                              16    5631
NP_963846                                                              16    5631
NP_000981                                                              16    5631
XP_005273507                                                           16    5631
XP_005249622                                                           16    5631
XP_005249621                                                           16    5631
NP_001121132                                                           16    7355
NP_055689                                                              16    7355
NP_001268885                                                           16    7355
NP_001020414                                                           16    7355
NP_001020413                                                           16    7355
NP_001560                                                              16    7355
NP_001127928                                                           16    7355
NP_659474                                                              16    7355
NP_115686                                                              16    7355
XP_005274725                                                           16    7355
XP_005252330                                                           16    7355
XP_005263605                                                           16    7355
XP_005263604                                                           16    7355
XP_005263602                                                           16    7355
XP_005263600                                                           16    7355
NP_001243632                                                           15    9605
NP_001243633                                                           15    9605
NP_002033                                                              15    9605
NP_001254511                                                           15    9605
NP_001135797                                                           15    9605
NP_001135796                                                           15    9605
NP_003044                                                              15    9605
NP_001129163                                                           15    9605
NP_057735                                                              15    9605
NP_689854                                                              15    9605
NP_037374                                                              15    9605
NP_001017923                                                           15    9605
NP_002034                                                              15    9605
XP_006723875                                                           15    9605
XP_006723874                                                           15    9605
XP_005260273                                                           15    9605
XP_006723871                                                           15    9605
XP_006723870                                                           15    9605
XP_006723869                                                           15    9605
XP_005267373                                                           15    9605
XP_006719336                                                           15    9605
XP_006719335                                                           15    9605
XP_006715501                                                           15    9605
NP_001005214                                                           15    9605
NP_001072988                                                           15    9605
NP_009007                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGFYKLLYI 9
           SGFYKLL I
Sbjct: 664 SGFYKLLSI 672
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SGFYKLLYI 9
           SGFYKLL I
Sbjct: 664 SGFYKLLSI 672
>NP_071756
          Length = 291

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGFYKLLYI 9
          SGF+ LLY+
Sbjct: 45 SGFFGLLYV 53
>NP_004934
          Length = 674

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GFYKLL 7
          GFYKLL
Sbjct: 31 GFYKLL 36
>NP_002728
          Length = 672

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGFYKLL 7
           SG+YKLL
Sbjct: 272 SGWYKLL 278
>NP_005364
          Length = 635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGFYKLLY 8
          SG Y+LLY
Sbjct: 60 SGTYQLLY 67
>NP_001265225
          Length = 730

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GFYKLLY 8
           GF KLLY
Sbjct: 295 GFQKLLY 301
>NP_001265224
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GFYKLLY 8
           GF KLLY
Sbjct: 349 GFQKLLY 355
>NP_919278
          Length = 1925

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GFYKLLY 8
           GF KLLY
Sbjct: 360 GFQKLLY 366
>XP_006722035
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SGFYKLL 7
           SG+YKLL
Sbjct: 272 SGWYKLL 278
>XP_006712460
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GFYKLLY 8
           GF KLLY
Sbjct: 349 GFQKLLY 355
>XP_006712459
          Length = 1914

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   GFYKLLY 8
           GF KLLY
Sbjct: 349 GFQKLLY 355
>NP_055486
          Length = 1083

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SGFYKLLYI 9
           +G+Y+ LY+
Sbjct: 205 NGYYRSLYL 213
>NP_001728
          Length = 559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GFYKLLYI 9
           G Y+L+Y+
Sbjct: 354 GLYELIYV 361
>NP_671736
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGFYKL 6
          SGFYK+
Sbjct: 94 SGFYKI 99
>NP_004458
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGFYKL 6
          SGFYK+
Sbjct: 94 SGFYKI 99
>NP_963847
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGFYKL 6
          SGFYK+
Sbjct: 94 SGFYKI 99
>NP_963846
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SGFYKL 6
          SGFYK+
Sbjct: 94 SGFYKI 99
>NP_000981
          Length = 148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SGFYKLL 7
           SG+YK+L
Sbjct: 106 SGYYKVL 112
>XP_005273507
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGFYKL 6
           SGFYK+
Sbjct: 144 SGFYKI 149
>XP_005249622
          Length = 1021

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SGFYKLLYI 9
           +G+Y+ LY+
Sbjct: 205 NGYYRSLYL 213
>XP_005249621
          Length = 1058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   SGFYKLLYI 9
           +G+Y+ LY+
Sbjct: 180 NGYYRSLYL 188
>NP_001121132
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>NP_055689
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>NP_001268885
          Length = 3631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    FYKLLY 8
            FYKLL+
Sbjct: 2720 FYKLLF 2725
>NP_001020414
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFY L+Y
Sbjct: 281 NGFYCLVY 288
>NP_001020413
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFY L+Y
Sbjct: 281 NGFYCLVY 288
>NP_001560
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFY L+Y
Sbjct: 281 NGFYCLVY 288
>NP_001127928
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFYK+ +
Sbjct: 166 NGFYKVFF 173
>NP_659474
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFYK+ +
Sbjct: 166 NGFYKVFF 173
>NP_115686
          Length = 183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  FYKLLYI 9
          FY+ LYI
Sbjct: 80 FYRALYI 86
>XP_005274725
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SGFYKLLY 8
           +GFY L+Y
Sbjct: 307 NGFYCLVY 314
>XP_005252330
          Length = 163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  FYKLLYI 9
          FY+ LYI
Sbjct: 80 FYRALYI 86
>XP_005263605
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>XP_005263604
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>XP_005263602
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>XP_005263600
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GFYKLLYI 9
           G Y LLY+
Sbjct: 639 GLYGLLYV 646
>NP_001243632
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 248 TGWYNRLYI 256
>NP_001243633
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 178 TGWYNRLYI 186
>NP_002033
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 265 TGWYNRLYI 273
>NP_001254511
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 178 TGWYNRLYI 186
>NP_001135797
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           SG Y LL++
Sbjct: 187 SGTYTLLFV 195
>NP_001135796
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           SG Y LL++
Sbjct: 187 SGTYTLLFV 195
>NP_003044
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           SG Y LL++
Sbjct: 187 SGTYTLLFV 195
>NP_001129163
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           SG Y LL++
Sbjct: 187 SGTYTLLFV 195
>NP_057735
          Length = 836

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGFYKL 6
           SGFY+L
Sbjct: 159 SGFYEL 164
>NP_689854
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGFYKLL 7
           +GFYK L
Sbjct: 565 TGFYKCL 571
>NP_037374
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  SGFYKLLY 8
          SGF  +LY
Sbjct: 8  SGFLSILY 15
>NP_001017923
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GFYKLLYI 9
          GF  LLY+
Sbjct: 61 GFLMLLYV 68
>NP_002034
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 245 TGWYNRLYI 253
>XP_006723875
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  FYKLLY 8
          FYKLL+
Sbjct: 19 FYKLLH 24
>XP_006723874
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKLLY 8
           FYKLL+
Sbjct: 119 FYKLLH 124
>XP_005260273
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKLLY 8
           FYKLL+
Sbjct: 135 FYKLLH 140
>XP_006723871
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKLLY 8
           FYKLL+
Sbjct: 134 FYKLLH 139
>XP_006723870
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKLLY 8
           FYKLL+
Sbjct: 135 FYKLLH 140
>XP_006723869
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FYKLLY 8
           FYKLL+
Sbjct: 135 FYKLLH 140
>XP_005267373
          Length = 231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  GFYKLLYI 9
          GF  LLY+
Sbjct: 61 GFLMLLYV 68
>XP_006719336
          Length = 1779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGFYKLL 7
           +GFYK L
Sbjct: 509 TGFYKCL 515
>XP_006719335
          Length = 1793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SGFYKLL 7
           +GFYK L
Sbjct: 565 TGFYKCL 571
>XP_006715501
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SGFYKLLYI 9
           +G+Y  LYI
Sbjct: 266 TGWYNRLYI 274
>NP_001005214
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GFYKLLYI 9
           G +KL+Y+
Sbjct: 99  GVFKLIYL 106
>NP_001072988
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SGFYKL 6
           SGFY+L
Sbjct: 159 SGFYEL 164
>NP_009007
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YKLLYI 9
           YKL+YI
Sbjct: 357 YKLVYI 362
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.160    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 561,007
Number of extensions: 853
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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