Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              19     665
NP_001009936                                                           17    2528
NP_001931                                                              17    3301
NP_001007027                                                           17    3301
NP_000946                                                              17    3301
NP_783329                                                              17    4312
NP_783328                                                              17    4312
NP_072046                                                              17    4312
NP_055633                                                              17    4312
XP_006726573                                                           17    4312
XP_006718461                                                           17    4312
XP_006718460                                                           17    4312
XP_006717415                                                           17    4312
XP_006712020                                                           17    4312
XP_005264233                                                           17    4312
XP_005264232                                                           17    4312
XP_006710285                                                           17    4312
NP_005561                                                              16    5631
NP_004200                                                              16    5631
XP_005276508                                                           16    5631
XP_005268314                                                           16    5631
XP_005275803                                                           16    5631
NP_116023                                                              16    7355
NP_001277738                                                           16    7355
NP_387512                                                              16    7355
NP_001269492                                                           16    7355
NP_000787                                                              16    7355
NP_620411                                                              16    7355
NP_057290                                                              16    7355
NP_620689                                                              16    7355
NP_001274265                                                           16    7355
NP_001274264                                                           16    7355
NP_001073153                                                           16    7355
NP_001073152                                                           16    7355
NP_065177                                                              16    7355
XP_006723595                                                           16    7355
XP_005271777                                                           16    7355
XP_005251676                                                           16    7355
XP_005266003                                                           16    7355
XP_005266002                                                           16    7355
XP_005265998                                                           16    7355
XP_006713585                                                           16    7355
XP_006713202                                                           16    7355
XP_005264809                                                           16    7355
XP_006713201                                                           16    7355
NP_077719                                                              15    9605
NP_612486                                                              15    9605
NP_061939                                                              15    9605
NP_056094                                                              15    9605
NP_001258751                                                           15    9605
NP_001073626                                                           15    9605
NP_115885                                                              15    9605
NP_005413                                                              15    9605
NP_001180247                                                           15    9605
XP_006726466                                                           15    9605
XP_005254235                                                           15    9605
XP_005254233                                                           15    9605
XP_005254234                                                           15    9605
XP_006719806                                                           15    9605
XP_006719623                                                           15    9605
XP_005269136                                                           15    9605
XP_005269138                                                           15    9605
XP_006719364                                                           15    9605
XP_006719363                                                           15    9605
XP_005271710                                                           15    9605
XP_006712969                                                           15    9605
XP_005270959                                                           15    9605
XP_005270958                                                           15    9605
XP_006710730                                                           15    9605
XP_006710208                                                           15    9605
NP_001177983                                                           15    9605
>NP_115803
          Length = 1156

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SGASQALPS 9
           SGAS+ALPS
Sbjct: 418 SGASRALPS 426
>NP_001009936
          Length = 207

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SGASQALPS 9
           SGA Q LPS
Sbjct: 171 SGADQRLPS 179
>NP_001931
          Length = 1190

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ASQALPS 9
           ASQALPS
Sbjct: 401 ASQALPS 407
>NP_001007027
          Length = 1190

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   ASQALPS 9
           ASQALPS
Sbjct: 401 ASQALPS 407
>NP_000946
          Length = 402

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          SGAS ALP
Sbjct: 32 SGASPALP 39
>NP_783329
          Length = 166

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>NP_783328
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>NP_072046
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>NP_055633
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           +GA QA+PS
Sbjct: 664 AGAPQAVPS 672
>XP_006726573
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           SG+S +LPS
Sbjct: 136 SGSSSSLPS 144
>XP_006718461
          Length = 1247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           +GA QA+PS
Sbjct: 664 AGAPQAVPS 672
>XP_006718460
          Length = 1392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           +GA QA+PS
Sbjct: 809 AGAPQAVPS 817
>XP_006717415
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           SG+S +LPS
Sbjct: 136 SGSSSSLPS 144
>XP_006712020
          Length = 806

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>XP_005264233
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>XP_005264232
          Length = 912

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SGASQALPS 9
          SGAS+ LP+
Sbjct: 82 SGASELLPN 90
>XP_006710285
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           SG+S +LPS
Sbjct: 136 SGSSSSLPS 144
>NP_005561
          Length = 510

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   GASQALPS 9
           GASQAL S
Sbjct: 182 GASQALAS 189
>NP_004200
          Length = 229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           +GASQA P
Sbjct: 187 TGASQAYP 194
>XP_005276508
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SGA +ALP
Sbjct: 177 SGAERALP 184
>XP_005268314
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SGA +ALP
Sbjct: 177 SGAERALP 184
>XP_005275803
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SGA +ALP
Sbjct: 177 SGAERALP 184
>NP_116023
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SGASQALP 8
           SGAS  LP
Sbjct: 737 SGASMVLP 744
>NP_001277738
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          +GASQA P
Sbjct: 21 TGASQARP 28
>NP_387512
          Length = 367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          +GASQA P
Sbjct: 21 TGASQARP 28
>NP_001269492
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          +GASQA P
Sbjct: 21 TGASQARP 28
>NP_000787
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          +GASQA P
Sbjct: 21 TGASQARP 28
>NP_620411
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ASQALPS 9
           +SQALPS
Sbjct: 338 SSQALPS 344
>NP_057290
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GASQALPS 9
          GASQ LP+
Sbjct: 14 GASQYLPN 21
>NP_620689
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  GASQALPS 9
          GA+Q+LP+
Sbjct: 45 GAAQSLPA 52
>NP_001274265
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 175 SGSSTALP 182
>NP_001274264
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 113 SGSSTALP 120
>NP_001073153
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 194 SGSSTALP 201
>NP_001073152
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 175 SGSSTALP 182
>NP_065177
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 194 SGSSTALP 201
>XP_006723595
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ASQALPS 9
           +SQALPS
Sbjct: 398 SSQALPS 404
>XP_005271777
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ASQALPS 9
           +SQALPS
Sbjct: 159 SSQALPS 165
>XP_005251676
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   SGASQALP 8
           SGAS  LP
Sbjct: 737 SGASMVLP 744
>XP_005266003
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 175 SGSSTALP 182
>XP_005266002
          Length = 203

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          SG+S ALP
Sbjct: 92 SGSSTALP 99
>XP_005265998
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           SG+S ALP
Sbjct: 175 SGSSTALP 182
>XP_006713585
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  SGASQALP 8
          +GASQA P
Sbjct: 21 TGASQARP 28
>XP_006713202
          Length = 273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GASQALPS 9
          GASQ LP+
Sbjct: 14 GASQYLPN 21
>XP_005264809
          Length = 320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GASQALPS 9
          GASQ LP+
Sbjct: 14 GASQYLPN 21
>XP_006713201
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  GASQALPS 9
          GASQ LP+
Sbjct: 14 GASQYLPN 21
>NP_077719
          Length = 2471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GASQALPS 9
            GAS  LPS
Sbjct: 2213 GASTVLPS 2220
>NP_612486
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GASQALP 8
          GAS ALP
Sbjct: 77 GASAALP 83
>NP_061939
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SGASQALPS 9
           S ASQA+P+
Sbjct: 845 SKASQAVPT 853
>NP_056094
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GASQALPS 9
           GA++A PS
Sbjct: 605 GAAEAFPS 612
>NP_001258751
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 GASQALP 8
         GA+Q+LP
Sbjct: 2 GAAQSLP 8
>NP_001073626
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 118 SQALPS 123
>NP_115885
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 118 SQALPS 123
>NP_005413
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GASQALPS 9
           GAS A PS
Sbjct: 726 GASYAFPS 733
>NP_001180247
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 241 SQALPS 246
>XP_006726466
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           S +SQALP
Sbjct: 932 SDSSQALP 939
>XP_005254235
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GASQALP 8
          GAS ALP
Sbjct: 77 GASAALP 83
>XP_005254233
          Length = 1228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GASQALP 8
          GAS ALP
Sbjct: 77 GASAALP 83
>XP_005254234
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  GASQALP 8
          GAS ALP
Sbjct: 77 GASAALP 83
>XP_006719806
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 457 SQALPS 462
>XP_006719623
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 118 SQALPS 123
>XP_005269136
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 152 SQALPS 157
>XP_005269138
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 166 SQALPS 171
>XP_006719364
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GASQALPS 9
           GA++A PS
Sbjct: 768 GAAEAFPS 775
>XP_006719363
          Length = 944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GASQALPS 9
           GA++A PS
Sbjct: 788 GAAEAFPS 795
>XP_005271710
          Length = 2150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GASQALPS 9
           GAS A PS
Sbjct: 726 GASYAFPS 733
>XP_006712969
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           S +SQALP
Sbjct: 932 SDSSQALP 939
>XP_005270959
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GASQALPS 9
            GAS  LPS
Sbjct: 2174 GASTVLPS 2181
>XP_005270958
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GASQALPS 9
            GAS  LPS
Sbjct: 2174 GASTVLPS 2181
>XP_006710730
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GASQALPS 9
            GAS  LPS
Sbjct: 2174 GASTVLPS 2181
>XP_006710208
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SGASQALP 8
           S +SQALP
Sbjct: 288 SDSSQALP 295
>NP_001177983
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQALPS 9
           SQALPS
Sbjct: 344 SQALPS 349
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.105    0.261 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 550,516
Number of extensions: 1128
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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