Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     509
NP_671714                                                              20     509
NP_006022                                                              20     509
XP_005261186                                                           20     509
XP_005261185                                                           20     509
XP_005261184                                                           20     509
XP_005261183                                                           20     509
XP_005261182                                                           20     509
XP_005261181                                                           20     509
XP_006715890                                                           20     509
XP_005250160                                                           20     509
XP_005250159                                                           20     509
NP_001162                                                              16    5631
NP_001002858                                                           16    5631
NP_001129487                                                           16    5631
NP_004030                                                              16    5631
NP_001002857                                                           16    5631
XP_005255367                                                           16    5631
XP_006725257                                                           16    5631
XP_006725256                                                           16    5631
XP_005255877                                                           16    5631
XP_005255876                                                           16    5631
XP_005255874                                                           16    5631
XP_006721218                                                           16    5631
XP_005255872                                                           16    5631
NP_710155                                                              16    5631
NP_001485                                                              16    7355
NP_001108628                                                           16    7355
NP_003165                                                              15    9605
NP_068506                                                              15    9605
NP_064587                                                              15    9605
NP_068817                                                              15    9605
NP_110419                                                              15    9605
NP_065937                                                              15    9605
XP_005271698                                                           15    9605
XP_005271696                                                           15    9605
XP_005271695                                                           15    9605
XP_005271694                                                           15    9605
XP_005271693                                                           15    9605
XP_005271690                                                           15    9605
XP_005271689                                                           15    9605
XP_005271688                                                           15    9605
XP_005271687                                                           15    9605
XP_006718760                                                           15    9605
XP_006718759                                                           15    9605
XP_006718758                                                           15    9605
XP_006718757                                                           15    9605
XP_006717559                                                           15    9605
XP_006717558                                                           15    9605
XP_006717557                                                           15    9605
XP_006717556                                                           15    9605
XP_005252630                                                           15    9605
XP_005252629                                                           15    9605
XP_005252628                                                           15    9605
XP_005252627                                                           15    9605
XP_005252626                                                           15    9605
XP_005252625                                                           15    9605
XP_005252624                                                           15    9605
XP_005252623                                                           15    9605
XP_005252622                                                           15    9605
XP_006717555                                                           15    9605
XP_005252621                                                           15    9605
XP_005250515                                                           15    9605
XP_005250514                                                           15    9605
XP_006714586                                                           15    9605
XP_005263030                                                           15    9605
NP_061877                                                              15    9605
NP_005130                                                              15    9605
>NP_005742
          Length = 3907

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3710 SFRKALIY 3717
>NP_671714
          Length = 3899

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3702 SFRKALIY 3709
>NP_006022
          Length = 3336

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3144 SFRKALIY 3151
>XP_005261186
          Length = 3139

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 2947 SFRKALIY 2954
>XP_005261185
          Length = 3229

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3037 SFRKALIY 3044
>XP_005261184
          Length = 3258

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3155 SFRKALIY 3162
>XP_005261183
          Length = 3268

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3076 SFRKALIY 3083
>XP_005261182
          Length = 3346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3154 SFRKALIY 3161
>XP_005261181
          Length = 3347

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3155 SFRKALIY 3162
>XP_006715890
          Length = 3860

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3663 SFRKALIY 3670
>XP_005250160
          Length = 3939

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3742 SFRKALIY 3749
>XP_005250159
          Length = 3952

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SFRKALIY 8
            SFRKALIY
Sbjct: 3755 SFRKALIY 3762
>NP_001162
          Length = 1503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           +RKA +YL
Sbjct: 768 YRKAAVYL 775
>NP_001002858
          Length = 357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FRKALIYL 9
           ++KAL+YL
Sbjct: 345 YQKALLYL 352
>NP_001129487
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FRKALIYL 9
           ++KAL+YL
Sbjct: 327 YQKALLYL 334
>NP_004030
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FRKALIYL 9
           ++KAL+YL
Sbjct: 327 YQKALLYL 334
>NP_001002857
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   FRKALIYL 9
           ++KAL+YL
Sbjct: 327 YQKALLYL 334
>XP_005255367
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           +RKA +YL
Sbjct: 869 YRKAAVYL 876
>XP_006725257
          Length = 972

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           +RKA +YL
Sbjct: 869 YRKAAVYL 876
>XP_006725256
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           +RKA +YL
Sbjct: 869 YRKAAVYL 876
>XP_005255877
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRKALIYL 9
          F KAL+YL
Sbjct: 82 FGKALLYL 89
>XP_005255876
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FRKALIYL 9
          F KAL+YL
Sbjct: 82 FGKALLYL 89
>XP_005255874
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           F KAL+YL
Sbjct: 137 FGKALLYL 144
>XP_006721218
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           F KAL+YL
Sbjct: 137 FGKALLYL 144
>XP_005255872
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           F KAL+YL
Sbjct: 160 FGKALLYL 167
>NP_710155
          Length = 407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           F KAL+YL
Sbjct: 137 FGKALLYL 144
>NP_001485
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           FRK L+Y+
Sbjct: 140 FRKFLVYV 147
>NP_001108628
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           FRK L+Y+
Sbjct: 95  FRKFLVYV 102
>NP_003165
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1493 KALIYL 1498
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1919 KALIYL 1924
>NP_064587
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  SFRKALIYL 9
          SFR ALI L
Sbjct: 3  SFRLALIQL 11
>NP_068817
          Length = 1093

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SFRKALIY 8
           SF+ AL+Y
Sbjct: 802 SFQSALLY 809
>NP_110419
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SFRKAL 6
           SFRKAL
Sbjct: 247 SFRKAL 252
>NP_065937
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 895 FRKVSVYL 902
>XP_005271698
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 738 FRKVSVYL 745
>XP_005271696
          Length = 1045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 863 FRKVSVYL 870
>XP_005271695
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 864 FRKVSVYL 871
>XP_005271694
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 896 FRKVSVYL 903
>XP_005271693
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 898 FRKVSVYL 905
>XP_005271690
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 936 FRKVSVYL 943
>XP_005271689
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 955 FRKVSVYL 962
>XP_005271688
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 957 FRKVSVYL 964
>XP_005271687
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FRKALIYL 9
           FRK  +YL
Sbjct: 958 FRKVSVYL 965
>XP_006718760
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SFRKAL 6
           SFRKAL
Sbjct: 247 SFRKAL 252
>XP_006718759
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SFRKAL 6
           SFRKAL
Sbjct: 247 SFRKAL 252
>XP_006718758
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SFRKAL 6
           SFRKAL
Sbjct: 247 SFRKAL 252
>XP_006718757
          Length = 611

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SFRKAL 6
           SFRKAL
Sbjct: 247 SFRKAL 252
>XP_006717559
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1571 KALIYL 1576
>XP_006717558
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1613 KALIYL 1618
>XP_006717557
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1645 KALIYL 1650
>XP_006717556
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1729 KALIYL 1734
>XP_005252630
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252629
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252628
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252627
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1961 KALIYL 1966
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1965 KALIYL 1970
>XP_005252625
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1982 KALIYL 1987
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 1997 KALIYL 2002
>XP_005252623
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 2007 KALIYL 2012
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 2013 KALIYL 2018
>XP_006717555
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 2033 KALIYL 2038
>XP_005252621
          Length = 2334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KALIYL 9
            KALIYL
Sbjct: 2039 KALIYL 2044
>XP_005250515
          Length = 1083

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  FRKALI 7
          FRKALI
Sbjct: 8  FRKALI 13
>XP_005250514
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  FRKALI 7
          FRKALI
Sbjct: 8  FRKALI 13
>XP_006714586
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SFRKALIY 8
           SF+ AL+Y
Sbjct: 744 SFQSALLY 751
>XP_005263030
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           FRKAL+ L
Sbjct: 152 FRKALLTL 159
>NP_061877
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  FRKALI 7
          FRKALI
Sbjct: 8  FRKALI 13
>NP_005130
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FRKALIYL 9
           FRKAL+ L
Sbjct: 152 FRKALLTL 159
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.152    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,505
Number of extensions: 510
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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