Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           21     229
NP_858045                                                              21     229
NP_006525                                                              21     229
NP_001167559                                                           21     229
NP_003296                                                              18    1935
NP_001124170                                                           18    1935
NP_003696                                                              17    3301
XP_005246980                                                           17    3301
NP_001153682                                                           17    4312
NP_065188                                                              17    4312
NP_001027566                                                           17    4312
NP_001027567                                                           17    4312
NP_055066                                                              17    4312
NP_940971                                                              17    4312
NP_542376                                                              17    4312
NP_004361                                                              17    4312
XP_006715896                                                           17    4312
XP_006715895                                                           17    4312
XP_006715894                                                           17    4312
XP_006715893                                                           17    4312
XP_005267118                                                           17    4312
XP_006715581                                                           17    4312
XP_006715580                                                           17    4312
XP_006715579                                                           17    4312
XP_006715397                                                           17    4312
NP_001074011                                                           16    5631
NP_001175                                                              16    7355
NP_004280                                                              16    7355
NP_001273028                                                           16    7355
NP_068817                                                              16    7355
NP_001239160                                                           16    7355
NP_001013683                                                           16    7355
NP_005272                                                              16    7355
NP_005275                                                              16    7355
XP_005271911                                                           16    7355
NP_002309                                                              15    9605
NP_849189                                                              15    9605
NP_002541                                                              15    9605
NP_002542                                                              15    9605
NP_005672                                                              15    9605
NP_001188465                                                           15    9605
NP_647603                                                              15    9605
NP_057422                                                              15    9605
NP_055797                                                              15    9605
XP_005267486                                                           15    9605
XP_006720145                                                           15    9605
XP_005267485                                                           15    9605
XP_005267483                                                           15    9605
XP_005267482                                                           15    9605
XP_005267481                                                           15    9605
XP_005267480                                                           15    9605
XP_005267479                                                           15    9605
XP_005267478                                                           15    9605
XP_005267477                                                           15    9605
XP_005269574                                                           15    9605
XP_006717681                                                           15    9605
XP_005273400                                                           15    9605
XP_006711676                                                           15    9605
NP_001128251                                                           15    9605
>NP_001167558
          Length = 1423

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SFNSMINQM 9
            SFNSM+NQM
Sbjct: 1134 SFNSMMNQM 1142
>NP_858045
          Length = 1424

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SFNSMINQM 9
            SFNSM+NQM
Sbjct: 1134 SFNSMMNQM 1142
>NP_006525
          Length = 1420

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SFNSMINQM 9
            SFNSM+NQM
Sbjct: 1134 SFNSMMNQM 1142
>NP_001167559
          Length = 1415

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SFNSMINQM 9
            SFNSM+NQM
Sbjct: 1129 SFNSMMNQM 1137
>NP_003296
          Length = 848

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SFNSMINQ 8
           SFNS++NQ
Sbjct: 764 SFNSILNQ 771
>NP_001124170
          Length = 921

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SFNSMINQ 8
           SFNS++NQ
Sbjct: 837 SFNSILNQ 844
>NP_003696
          Length = 678

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SFNSMINQM 9
           +FNS++N M
Sbjct: 221 AFNSLLNNM 229
>XP_005246980
          Length = 661

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SFNSMINQM 9
           +FNS++N M
Sbjct: 204 AFNSLLNNM 212
>NP_001153682
          Length = 676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 223 FNSLLNNM 230
>NP_065188
          Length = 1221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 119 SFNSSANEM 127
>NP_001027566
          Length = 1193

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 119 SFNSSANEM 127
>NP_001027567
          Length = 1222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 119 SFNSSANEM 127
>NP_055066
          Length = 675

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 223 FNSLLNNM 230
>NP_940971
          Length = 1250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 119 SFNSSANEM 127
>NP_542376
          Length = 1899

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FNSMINQM 9
            FN M+NQ+
Sbjct: 1759 FNQMLNQI 1766
>NP_004361
          Length = 3063

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FNSMINQM 9
            FN M+NQ+
Sbjct: 2923 FNQMLNQI 2930
>XP_006715896
          Length = 457

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 234 FNSLLNNM 241
>XP_006715895
          Length = 568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 115 FNSLLNNM 122
>XP_006715894
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 234 FNSLLNNM 241
>XP_006715893
          Length = 687

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FNS++N M
Sbjct: 234 FNSLLNNM 241
>XP_005267118
          Length = 1222

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 120 SFNSSANEM 128
>XP_006715581
          Length = 1223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 120 SFNSSANEM 128
>XP_006715580
          Length = 1249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 118 SFNSSANEM 126
>XP_006715579
          Length = 1251

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFNS  N+M
Sbjct: 120 SFNSSANEM 128
>XP_006715397
          Length = 2972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    FNSMINQM 9
            FN M+NQ+
Sbjct: 2832 FNQMLNQI 2839
>NP_001074011
          Length = 1133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SFNSMINQM 9
           S NS+I+QM
Sbjct: 735 SLNSIIHQM 743
>NP_001175
          Length = 2644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    FNSMINQ 8
            FNS+IN+
Sbjct: 2341 FNSLINK 2347
>NP_004280
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SFNSMINQ 8
           SFNSM+++
Sbjct: 561 SFNSMLSR 568
>NP_001273028
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           ++NSMIN
Sbjct: 334 TYNSMIN 340
>NP_068817
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FNSMINQ 8
           FNS +NQ
Sbjct: 239 FNSAVNQ 245
>NP_001239160
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FNSMINQ 8
           FNS +NQ
Sbjct: 239 FNSAVNQ 245
>NP_001013683
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SFNSMINQ 8
           SF+S INQ
Sbjct: 210 SFHSSINQ 217
>NP_005272
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           ++NSMIN
Sbjct: 287 TYNSMIN 293
>NP_005275
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           ++NSMIN
Sbjct: 319 TYNSMIN 325
>XP_005271911
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FNSMINQ 8
           FNS +NQ
Sbjct: 239 FNSAVNQ 245
>NP_002309
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NSMINQM 9
           NS+INQ+
Sbjct: 170 NSLINQI 176
>NP_849189
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           SFN+++N
Sbjct: 125 SFNALVN 131
>NP_002541
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FN++IN M
Sbjct: 280 FNTVINPM 287
>NP_002542
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FNSMINQM 9
           FN++IN M
Sbjct: 286 FNTVINPM 293
>NP_005672
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFN+  N+M
Sbjct: 117 SFNTFANRM 125
>NP_001188465
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFN+  N+M
Sbjct: 117 SFNTFANRM 125
>NP_647603
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SFNSMINQM 9
          SFN+  N+M
Sbjct: 3  SFNTFANRM 11
>NP_057422
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   FNSMINQM 9
           F+S++N+M
Sbjct: 806 FSSLLNEM 813
>NP_055797
          Length = 2341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2170 SMVNQM 2175
>XP_005267486
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 1250 SMVNQM 1255
>XP_006720145
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 1252 SMVNQM 1257
>XP_005267485
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 1288 SMVNQM 1293
>XP_005267483
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2059 SMVNQM 2064
>XP_005267482
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2072 SMVNQM 2077
>XP_005267481
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2122 SMVNQM 2127
>XP_005267480
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2165 SMVNQM 2170
>XP_005267479
          Length = 2344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2173 SMVNQM 2178
>XP_005267478
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2177 SMVNQM 2182
>XP_005267477
          Length = 2349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SMINQM 9
            SM+NQM
Sbjct: 2178 SMVNQM 2183
>XP_005269574
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           SFN+++N
Sbjct: 137 SFNALVN 143
>XP_006717681
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SFNSMIN 7
           SFN+++N
Sbjct: 143 SFNALVN 149
>XP_005273400
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SFNSMINQM 9
           SFN+  N+M
Sbjct: 117 SFNTFANRM 125
>XP_006711676
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SFNSMINQM 9
          SFN+  N+M
Sbjct: 3  SFNTFANRM 11
>NP_001128251
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   FNSMINQM 9
           F+S++N+M
Sbjct: 846 FSSLLNEM 853
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.120    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 332,903
Number of extensions: 415
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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