Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001600                                                              18    1135
XP_006725008                                                           18    1135
XP_005244808                                                           18    1135
NP_001010926                                                           18    1135
NP_001275701                                                           18    1935
NP_004561                                                              18    1935
NP_001275703                                                           18    1935
XP_005253450                                                           18    1935
XP_006719151                                                           18    1935
NP_001106819                                                           16    7355
NP_001106820                                                           16    7355
NP_001388                                                              16    7355
NP_001106818                                                           16    7355
NP_001243275                                                           16    7355
NP_056257                                                              16    7355
NP_002855                                                              16    7355
NP_000005                                                              16    7355
NP_001026872                                                           16    7355
NP_001243277                                                           16    7355
NP_001243276                                                           16    7355
NP_001243670                                                           16    7355
NP_001243671                                                           16    7355
XP_006719119                                                           16    7355
XP_006713148                                                           16    7355
XP_006713147                                                           16    7355
XP_006710461                                                           16    7355
NP_008958                                                              15    9605
NP_005498                                                              15    9605
NP_057250                                                              15    9605
NP_003433                                                              15    9605
NP_055051                                                              15    9605
NP_057595                                                              15    9605
NP_001269586                                                           15    9605
NP_001269585                                                           15    9605
XP_005254792                                                           15    9605
XP_005254791                                                           15    9605
XP_005253440                                                           15    9605
XP_005253183                                                           15    9605
XP_005253179                                                           15    9605
XP_005253178                                                           15    9605
XP_005247133                                                           15    9605
XP_005273371                                                           15    9605
XP_005273370                                                           15    9605
>NP_001600
          Length = 432

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   SFCLSEA 7
           SFCLSEA
Sbjct: 173 SFCLSEA 179
>XP_006725008
          Length = 198

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SFCLSEAVQ 9
           S+CL EAVQ
Sbjct: 125 SWCLQEAVQ 133
>XP_005244808
          Length = 198

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SFCLSEAVQ 9
           S+CL EAVQ
Sbjct: 125 SWCLQEAVQ 133
>NP_001010926
          Length = 166

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SFCLSEAVQ 9
           S+CL EAVQ
Sbjct: 93  SWCLQEAVQ 101
>NP_001275701
          Length = 1486

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SFCLSEAVQ 9
            SF LSEAVQ
Sbjct: 1343 SFFLSEAVQ 1351
>NP_004561
          Length = 1445

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SFCLSEAVQ 9
            SF LSEAVQ
Sbjct: 1302 SFFLSEAVQ 1310
>NP_001275703
          Length = 1264

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SFCLSEAVQ 9
            SF LSEAVQ
Sbjct: 1121 SFFLSEAVQ 1129
>XP_005253450
          Length = 1486

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SFCLSEAVQ 9
            SF LSEAVQ
Sbjct: 1343 SFFLSEAVQ 1351
>XP_006719151
          Length = 1486

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SFCLSEAVQ 9
            SF LSEAVQ
Sbjct: 1343 SFFLSEAVQ 1351
>NP_001106819
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SFCLSEA 7
          S CLSEA
Sbjct: 81 SVCLSEA 87
>NP_001106820
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SFCLSEA 7
           S CLSEA
Sbjct: 94  SVCLSEA 100
>NP_001388
          Length = 770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SFCLSEA 7
           S CLSEA
Sbjct: 97  SVCLSEA 103
>NP_001106818
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SFCLSEA 7
          S CLSEA
Sbjct: 85 SVCLSEA 91
>NP_001243275
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FCLSEAVQ 9
           F +SEAVQ
Sbjct: 449 FLMSEAVQ 456
>NP_056257
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           CL EAVQ
Sbjct: 377 CLIEAVQ 383
>NP_002855
          Length = 1482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SFCLSE 6
           +FCLSE
Sbjct: 775 AFCLSE 780
>NP_000005
          Length = 1474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SFCLSE 6
           +FCLSE
Sbjct: 769 AFCLSE 774
>NP_001026872
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FCLSEAVQ 9
           F +SEAVQ
Sbjct: 449 FLMSEAVQ 456
>NP_001243277
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FCLSEAVQ 9
           F +SEAVQ
Sbjct: 391 FLMSEAVQ 398
>NP_001243276
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FCLSEAVQ 9
           F +SEAVQ
Sbjct: 503 FLMSEAVQ 510
>NP_001243670
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           CL EAVQ
Sbjct: 377 CLIEAVQ 383
>NP_001243671
          Length = 804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           CL EAVQ
Sbjct: 437 CLIEAVQ 443
>XP_006719119
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SFCLSE 6
           +FCLSE
Sbjct: 769 AFCLSE 774
>XP_006713148
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           CL EAVQ
Sbjct: 437 CLIEAVQ 443
>XP_006713147
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           CL EAVQ
Sbjct: 437 CLIEAVQ 443
>XP_006710461
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SFCLSEA 7
          S CLSEA
Sbjct: 80 SVCLSEA 86
>NP_008958
          Length = 1522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SFCLSEAV 8
            ++CL EA+
Sbjct: 1483 NYCLPEAI 1490
>NP_005498
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  FCLSE 6
          FCLSE
Sbjct: 38 FCLSE 42
>NP_057250
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FCLSE 6
           FCLSE
Sbjct: 202 FCLSE 206
>NP_003433
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 27 TLCLTEAV 34
>NP_055051
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           C SEA+Q
Sbjct: 544 CKSEAIQ 550
>NP_057595
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FCLSE 6
           FCLSE
Sbjct: 164 FCLSE 168
>NP_001269586
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 27 TLCLTEAV 34
>NP_001269585
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 27 TLCLTEAV 34
>XP_005254792
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FCLSE 6
           FCLSE
Sbjct: 193 FCLSE 197
>XP_005254791
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FCLSE 6
           FCLSE
Sbjct: 195 FCLSE 199
>XP_005253440
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FCLSE 6
           FCLSE
Sbjct: 131 FCLSE 135
>XP_005253183
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 42 TLCLTEAV 49
>XP_005253179
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 42 TLCLTEAV 49
>XP_005253178
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SFCLSEAV 8
          + CL+EAV
Sbjct: 42 TLCLTEAV 49
>XP_005247133
          Length = 1517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    SFCLSEAV 8
            ++CL EA+
Sbjct: 1478 NYCLPEAI 1485
>XP_005273371
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           C SEA+Q
Sbjct: 483 CKSEAIQ 489
>XP_005273370
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CLSEAVQ 9
           C SEA+Q
Sbjct: 543 CKSEAIQ 549
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.125    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 493,854
Number of extensions: 330
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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