Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           21     175
NP_001257437                                                           21     175
NP_006281                                                              21     175
XP_006715618                                                           21     175
XP_005267176                                                           21     175
NP_001229416                                                           18    1482
NP_001229417                                                           18    1482
NP_055852                                                              18    1482
XP_005269712                                                           18    1482
XP_006717788                                                           18    1482
XP_005269710                                                           18    1482
XP_005269709                                                           18    1482
XP_005269708                                                           18    1482
XP_005269706                                                           18    1482
XP_005269705                                                           18    1482
NP_620572                                                              17    2528
NP_620578                                                              17    3301
NP_000401                                                              17    3301
NP_620576                                                              17    3301
NP_620573                                                              17    3301
NP_620579                                                              17    3301
NP_835464                                                              17    3301
XP_006715138                                                           17    3301
NP_001020402                                                           17    4312
NP_620575                                                              16    5631
NP_620577                                                              16    5631
NP_001264264                                                           16    5631
NP_001073346                                                           16    5631
NP_001013683                                                           16    5631
NP_008920                                                              16    5631
XP_006715892                                                           16    5631
XP_006715891                                                           16    5631
XP_005250161                                                           16    5631
XP_005250142                                                           16    5631
XP_005250141                                                           16    5631
NP_005142                                                              16    7355
NP_001032411" target = "next">NP_001032411                                                           16    7355
NP_683692                                                              16    7355
XP_005248208                                                           16    7355
XP_005248207                                                           16    7355
XP_006714021                                                           16    7355
NP_001191225                                                           15    9605
NP_001191223                                                           15    9605
NP_001191221                                                           15    9605
NP_001037855                                                           15    9605
NP_001037858                                                           15    9605
NP_001139                                                              15    9605
NP_001032                                                              15    9605
NP_001245283                                                           15    9605
NP_056011                                                              15    9605
NP_001124479                                                           15    9605
NP_004238                                                              15    9605
NP_001245282                                                           15    9605
NP_001136077                                                           15    9605
NP_008980                                                              15    9605
NP_510961                                                              15    9605
NP_001184169                                                           15    9605
NP_001184167                                                           15    9605
NP_001184166                                                           15    9605
NP_001184163                                                           15    9605
NP_008926                                                              15    9605
XP_006715019                                                           15    9605
XP_006715018                                                           15    9605
XP_006715016                                                           15    9605
XP_005248854                                                           15    9605
XP_006714257                                                           15    9605
XP_005263002                                                           15    9605
XP_005262999                                                           15    9605
XP_006714252                                                           15    9605
XP_006714251                                                           15    9605
XP_006714250                                                           15    9605
XP_005262928                                                           15    9605
XP_005262927                                                           15    9605
XP_005262926                                                           15    9605
>NP_001257436
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SETT MKCR
Sbjct: 471 SETTAMKCR 479
>NP_001257437
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SETT MKCR
Sbjct: 471 SETTAMKCR 479
>NP_006281
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SETT MKCR
Sbjct: 471 SETTAMKCR 479
>XP_006715618
          Length = 577

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SETT MKCR
Sbjct: 258 SETTAMKCR 266
>XP_005267176
          Length = 790

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SETT MKCR
Sbjct: 471 SETTAMKCR 479
>NP_001229416
          Length = 1837

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>NP_001229417
          Length = 1892

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>NP_055852
          Length = 1842

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>XP_005269712
          Length = 1800

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 863 SEMSTMRCR 871
>XP_006717788
          Length = 1829

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>XP_005269710
          Length = 1834

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>XP_005269709
          Length = 1871

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 863 SEMSTMRCR 871
>XP_005269708
          Length = 1897

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>XP_005269706
          Length = 1900

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>XP_005269705
          Length = 1905

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           SE +TM+CR
Sbjct: 897 SEMSTMRCR 905
>NP_620572
          Length = 242

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           S+ TT++CR
Sbjct: 112 SKVTTLRCR 120
>NP_620578
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S  TT++CR
Sbjct: 195 SSVTTLRCR 203
>NP_000401
          Length = 348

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S  TT++CR
Sbjct: 218 SSVTTLRCR 226
>NP_620576
          Length = 260

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S  TT++CR
Sbjct: 130 SSVTTLRCR 138
>NP_620573
          Length = 256

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S  TT++CR
Sbjct: 126 SSVTTLRCR 134
>NP_620579
          Length = 168

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  SETTTMKCR 9
          S  TT++CR
Sbjct: 38 SSVTTLRCR 46
>NP_835464
          Length = 692

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SETTTMKCR 9
           S TT+++CR
Sbjct: 288 SRTTSVRCR 296
>XP_006715138
          Length = 337

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S  TT++CR
Sbjct: 218 SSVTTLRCR 226
>NP_001020402
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SETTTMKCR 9
          S+TT +KC+
Sbjct: 67 SQTTQVKCQ 75
>NP_620575
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           + TT++CR
Sbjct: 205 QVTTLRCR 212
>NP_620577
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           + TT++CR
Sbjct: 117 QVTTLRCR 124
>NP_001264264
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>NP_001073346
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>NP_001013683
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SETTTMKCR 9
           S+T T +CR
Sbjct: 119 SDTATYECR 127
>NP_008920
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>XP_006715892
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ETTTMKCR 9
          ETT+ +CR
Sbjct: 13 ETTSTECR 20
>XP_006715891
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>XP_005250161
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>XP_005250142
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>XP_005250141
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETTTMKCR 9
           ETT+ +CR
Sbjct: 296 ETTSTECR 303
>NP_005142
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   TTMKC 8
           TTMKC
Sbjct: 253 TTMKC 257
>NP_001032411" target = "next">NP_001032411
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   TTMKC 8
           TTMKC
Sbjct: 218 TTMKC 222
>NP_683692
          Length = 3051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SETTTMKC 8
            S  TT+KC
Sbjct: 2157 SSATTIKC 2164
>XP_005248208
          Length = 3097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SETTTMKC 8
            S  TT+KC
Sbjct: 2157 SSATTIKC 2164
>XP_005248207
          Length = 3098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SETTTMKC 8
            S  TT+KC
Sbjct: 2157 SSATTIKC 2164
>XP_006714021
          Length = 3112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    SETTTMKC 8
            S  TT+KC
Sbjct: 2157 SSATTIKC 2164
>NP_001191225
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  TTTMKCR 9
          TTT  CR
Sbjct: 67 TTTKSCR 73
>NP_001191223
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  TTTMKCR 9
          TTT  CR
Sbjct: 58 TTTKSCR 64
>NP_001191221
          Length = 239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  TTTMKCR 9
          TTT  CR
Sbjct: 67 TTTKSCR 73
>NP_001037855
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  TTTMKCR 9
          TTT  CR
Sbjct: 58 TTTKSCR 64
>NP_001037858
          Length = 158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3  TTTMKCR 9
          TTT  CR
Sbjct: 58 TTTKSCR 64
>NP_001139
          Length = 3957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3446 SRSTTSSCR 3454
>NP_001032
          Length = 1827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    TTTMKCR 9
            TTT +CR
Sbjct: 1405 TTTNQCR 1411
>NP_001245283
          Length = 962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   ETTTMKC 8
           ET+++KC
Sbjct: 658 ETSSLKC 664
>NP_056011
          Length = 1609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETTTMKCR 9
           E+T M CR
Sbjct: 746 ESTLMDCR 753
>NP_001124479
          Length = 1610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETTTMKCR 9
           E+T M CR
Sbjct: 747 ESTLMDCR 754
>NP_004238
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   ETTTMKC 8
           ET+++KC
Sbjct: 668 ETSSLKC 674
>NP_001245282
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   ETTTMKC 8
           ET+++KC
Sbjct: 668 ETSSLKC 674
>NP_001136077
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   ETTTMKC 8
           ET+++KC
Sbjct: 633 ETSSLKC 639
>NP_008980
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 45 ENTTLRC 51
>NP_510961
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 45 ENTTLRC 51
>NP_001184169
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>NP_001184167
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>NP_001184166
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>NP_001184163
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 45 ENTTLRC 51
>NP_008926
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>XP_006715019
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 4  ENTTLRC 10
>XP_006715018
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>XP_006715016
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>XP_005248854
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2  ETTTMKC 8
          E TT++C
Sbjct: 49 ENTTLRC 55
>XP_006714257
          Length = 4145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3455 SRSTTSSCR 3463
>XP_005263002
          Length = 4072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3413 SRSTTSSCR 3421
>XP_005262999
          Length = 4147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3457 SRSTTSSCR 3465
>XP_006714252
          Length = 4153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3463 SRSTTSSCR 3471
>XP_006714251
          Length = 4165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3475 SRSTTSSCR 3483
>XP_006714250
          Length = 4190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    SETTTMKCR 9
            S +TT  CR
Sbjct: 3500 SRSTTSSCR 3508
>XP_005262928
          Length = 965

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETTTMKCR 9
           E+T M CR
Sbjct: 102 ESTLMDCR 109
>XP_005262927
          Length = 1526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETTTMKCR 9
           E+T M CR
Sbjct: 663 ESTLMDCR 670
>XP_005262926
          Length = 1609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETTTMKCR 9
           E+T M CR
Sbjct: 747 ESTLMDCR 754
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.109    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,598
Number of extensions: 873
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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