Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              21     229
XP_005273257                                                           21     229
NP_150375                                                              20     390
NP_775185                                                              20     390
NP_061985                                                              18    1482
XP_006722680                                                           18    1482
XP_006722679                                                           18    1482
NP_057319                                                              18    1935
NP_056080                                                              18    1935
NP_001165980                                                           18    1935
NP_001165988                                                           18    1935
XP_006721115                                                           18    1935
XP_006721114                                                           18    1935
XP_005255414                                                           18    1935
XP_005246453                                                           18    1935
XP_006712435                                                           18    1935
XP_006726509                                                           17    3301
XP_006716286                                                           17    3301
NP_001101                                                              16    5631
NP_000353                                                              16    5631
NP_061836                                                              16    5631
NP_387505                                                              16    5631
XP_005261051                                                           16    5631
XP_005254174                                                           16    5631
XP_006713181                                                           16    5631
NP_001025031                                                           16    5631
NP_005920                                                              16    7355
NP_060580                                                              16    7355
NP_201573                                                              16    7355
XP_005256100                                                           16    7355
XP_005256099                                                           16    7355
XP_006713707                                                           16    7355
XP_006713706                                                           16    7355
XP_006713705                                                           16    7355
NP_036499                                                              16    7355
NP_057427                                                              15    9605
NP_061875                                                              15    9605
NP_694953                                                              15    9605
NP_001121797                                                           15    9605
NP_036577                                                              15    9605
NP_001188408                                                           15    9605
NP_001188401                                                           15    9605
NP_001185950                                                           15    9605
NP_699197                                                              15    9605
NP_055295                                                              15    9605
NP_001188402                                                           15    9605
NP_079092                                                              15    9605
NP_078948                                                              15    9605
NP_078811                                                              15    9605
XP_005249902                                                           15    9605
XP_005263278                                                           15    9605
XP_005263277                                                           15    9605
XP_005264434                                                           15    9605
XP_005264433                                                           15    9605
XP_005264432                                                           15    9605
XP_005264431                                                           15    9605
>NP_064450
          Length = 1722

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SESLCSIRR 9
            SES+CSIRR
Sbjct: 1461 SESICSIRR 1469
>XP_005273257
          Length = 1726

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SESLCSIRR 9
            SES+CSIRR
Sbjct: 1465 SESICSIRR 1473
>NP_150375
          Length = 1196

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           ESLCSIRR
Sbjct: 265 ESLCSIRR 272
>NP_775185
          Length = 732

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           ESLCSIRR
Sbjct: 265 ESLCSIRR 272
>NP_061985
          Length = 2146

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SESLCSIR 8
           SE+LCS+R
Sbjct: 221 SEALCSVR 228
>XP_006722680
          Length = 1636

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SESLCSIR 8
           SE+LCS+R
Sbjct: 221 SEALCSVR 228
>XP_006722679
          Length = 2128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SESLCSIR 8
           SE+LCS+R
Sbjct: 221 SEALCSVR 228
>NP_057319
          Length = 403

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E++CS+RR
Sbjct: 119 ETICSVRR 126
>NP_056080
          Length = 733

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E+LC+IRR
Sbjct: 536 ENLCTIRR 543
>NP_001165980
          Length = 733

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E+LC+IRR
Sbjct: 536 ENLCTIRR 543
>NP_001165988
          Length = 733

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E+LC+IRR
Sbjct: 536 ENLCTIRR 543
>XP_006721115
          Length = 403

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E++CS+RR
Sbjct: 119 ETICSVRR 126
>XP_006721114
          Length = 403

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E++CS+RR
Sbjct: 119 ETICSVRR 126
>XP_005255414
          Length = 534

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E++CS+RR
Sbjct: 250 ETICSVRR 257
>XP_005246453
          Length = 675

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E+LC+IRR
Sbjct: 478 ENLCTIRR 485
>XP_006712435
          Length = 733

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ESLCSIRR 9
           E+LC+IRR
Sbjct: 536 ENLCTIRR 543
>XP_006726509
          Length = 142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SESLCSIR 8
          ++SLCS+R
Sbjct: 51 NQSLCSVR 58
>XP_006716286
          Length = 142

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  SESLCSIR 8
          ++SLCS+R
Sbjct: 51 NQSLCSVR 58
>NP_001101
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SLCSIR 8
           SLCSIR
Sbjct: 433 SLCSIR 438
>NP_000353
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  SESLCSIR 8
          SESLC ++
Sbjct: 87 SESLCGLK 94
>NP_061836
          Length = 2320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SESLCSIRR 9
            SES+CS R+
Sbjct: 1652 SESVCSGRK 1660
>NP_387505
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SESLCSIRR 9
            SES+CS R+
Sbjct: 1652 SESVCSGRK 1660
>XP_005261051
          Length = 2242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SESLCSIRR 9
            SES+CS R+
Sbjct: 1574 SESVCSGRK 1582
>XP_005254174
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SLCSIR 8
           SLCSIR
Sbjct: 402 SLCSIR 407
>XP_006713181
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ESLCSIRR 9
           E  CSIRR
Sbjct: 370 EPCCSIRR 377
>NP_001025031
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SESLCSI 7
           +ESLCS+
Sbjct: 519 AESLCSV 525
>NP_005920
          Length = 738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SESLCSIRR 9
           SESLC + R
Sbjct: 182 SESLCRLCR 190
>NP_060580
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCSIRR 9
           LCS+RR
Sbjct: 181 LCSLRR 186
>NP_201573
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SESLCSIRR 9
           SESLC + R
Sbjct: 182 SESLCRLCR 190
>XP_005256100
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCSIRR 9
           LCS+RR
Sbjct: 181 LCSLRR 186
>XP_005256099
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LCSIRR 9
           LCS+RR
Sbjct: 181 LCSLRR 186
>XP_006713707
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SESLCSIRR 9
           SESLC + R
Sbjct: 182 SESLCRLCR 190
>XP_006713706
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SESLCSIRR 9
           SESLC + R
Sbjct: 182 SESLCRLCR 190
>XP_006713705
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SESLCSIRR 9
           SESLC + R
Sbjct: 182 SESLCRLCR 190
>NP_036499
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SLCSIRR 9
          +LCSIR+
Sbjct: 84 NLCSIRK 90
>NP_057427
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    ESLCSIRR 9
            ESLC + R
Sbjct: 1553 ESLCEVYR 1560
>NP_061875
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 633 SESICEI 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 662 SESICEI 668
>NP_694953
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   SESLCSIRR 9
           S   CS+RR
Sbjct: 434 SSRCCSVRR 442
>NP_001121797
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  ESLCSIR 8
          ES+CS R
Sbjct: 32 ESICSAR 38
>NP_036577
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  ESLCSIR 8
          ES+CS R
Sbjct: 32 ESICSAR 38
>NP_001188408
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SESLCSIR 8
           +E +CS+R
Sbjct: 594 TEKICSLR 601
>NP_001188401
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SESLCSIR 8
           +E +CS+R
Sbjct: 576 TEKICSLR 583
>NP_001185950
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  ESLCSIR 8
          ES+CS R
Sbjct: 32 ESICSAR 38
>NP_699197
          Length = 3571

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   SESLCSIR 8
           SES C +R
Sbjct: 429 SESYCRVR 436
>NP_055295
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SESLCSIR 8
           SESLC ++
Sbjct: 308 SESLCLVQ 315
>NP_001188402
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SESLCSIR 8
           +E +CS+R
Sbjct: 509 TEKICSLR 516
>NP_079092
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SLCSIR 8
           SLCS+R
Sbjct: 480 SLCSLR 485
>NP_078948
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SESLC +
Sbjct: 765 SESLCRV 771
>NP_078811
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SESLCSIR 8
           +E +CS+R
Sbjct: 594 TEKICSLR 601
>XP_005249902
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   SLCSIR 8
           SLCS+R
Sbjct: 557 SLCSLR 562
>XP_005263278
          Length = 620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SESLC +
Sbjct: 482 SESLCRV 488
>XP_005263277
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SESLC +
Sbjct: 621 SESLCRV 627
>XP_005264434
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 550 SESICEI 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 579 SESICEI 585
>XP_005264433
          Length = 899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 635 SESICEI 641
>XP_005264432
          Length = 899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 635 SESICEI 641
>XP_005264431
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 635 SESICEI 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SESLCSI 7
           SES+C I
Sbjct: 664 SESICEI 670
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.126    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 676,536
Number of extensions: 686
Number of successful extensions: 59
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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