Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           20     299
NP_001185763                                                           20     299
NP_055459                                                              20     299
XP_006726410                                                           20     299
XP_006711719                                                           20     299
XP_006711718                                                           20     299
XP_006711717                                                           20     299
XP_006711716                                                           20     299
XP_006711715                                                           20     299
XP_006711714                                                           20     299
XP_006711713                                                           20     299
XP_006711712                                                           20     299
XP_006711711                                                           20     299
XP_006711710                                                           20     299
XP_006711709                                                           20     299
XP_005277503                                                           20     299
XP_005273038                                                           20     299
XP_006711708                                                           20     299
XP_005277500                                                           20     299
XP_006711707                                                           20     299
XP_005277499                                                           20     299
XP_006711706                                                           20     299
XP_006711705                                                           20     299
XP_006711164                                                           20     299
XP_006710143                                                           20     299
XP_006710142                                                           20     299
XP_006710141                                                           20     299
NP_001239264                                                           18    1482
NP_116255                                                              18    1482
XP_005254784                                                           18    1482
XP_005254783                                                           18    1482
NP_005251                                                              17    4312
NP_001073932                                                           16    5631
NP_001368                                                              16    5631
NP_004548                                                              16    5631
NP_060151                                                              16    5631
XP_005257785                                                           16    5631
XP_006718966                                                           16    5631
NP_115510                                                              16    5631
NP_149094                                                              16    7355
NP_683721                                                              16    7355
NP_003965                                                              16    7355
NP_001139806                                                           16    7355
NP_005986                                                              16    7355
XP_005256713                                                           16    7355
XP_006720059                                                           16    7355
XP_006716474                                                           16    7355
XP_005273738                                                           16    7355
XP_005273737                                                           16    7355
XP_006715737                                                           16    7355
XP_006710034                                                           16    7355
NP_055673                                                              15    9605
NP_001191344                                                           15    9605
NP_001191343                                                           15    9605
NP_114072                                                              15    9605
NP_071447                                                              15    9605
NP_003459                                                              15    9605
NP_777614                                                              15    9605
XP_006713148                                                           15    9605
XP_005245743                                                           15    9605
XP_005271164                                                           15    9605
XP_005271163                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1511 SEKDQAGLE 1519
>NP_001185763
          Length = 2362

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1555 SEKDQAGLE 1563
>NP_055459
          Length = 2346

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1555 SEKDQAGLE 1563
>XP_006726410
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1358 SEKDQAGLE 1366
>XP_006711719
          Length = 2302

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1511 SEKDQAGLE 1519
>XP_006711718
          Length = 1436

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SERDQAGLE 9
           SE+DQAGLE
Sbjct: 562 SEKDQAGLE 570
>XP_006711717
          Length = 2385

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1511 SEKDQAGLE 1519
>XP_006711716
          Length = 2411

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1620 SEKDQAGLE 1628
>XP_006711715
          Length = 2428

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1554 SEKDQAGLE 1562
>XP_006711714
          Length = 2429

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1555 SEKDQAGLE 1563
>XP_006711713
          Length = 2432

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1558 SEKDQAGLE 1566
>XP_006711712
          Length = 2473

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_006711711
          Length = 2482

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1608 SEKDQAGLE 1616
>XP_006711710
          Length = 2494

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1620 SEKDQAGLE 1628
>XP_006711709
          Length = 2495

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1621 SEKDQAGLE 1629
>XP_005277503
          Length = 2498

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_005273038
          Length = 2509

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_006711708
          Length = 2512

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_005277500
          Length = 2525

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_006711707
          Length = 2553

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_005277499
          Length = 2561

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_006711706
          Length = 2591

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1717 SEKDQAGLE 1725
>XP_006711705
          Length = 2592

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1718 SEKDQAGLE 1726
>XP_006711164
          Length = 2087

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SERDQAGLE 9
            SE+DQAGLE
Sbjct: 1358 SEKDQAGLE 1366
>XP_006710143
          Length = 562

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SERDQAGLE 9
           SE+DQAGLE
Sbjct: 397 SEKDQAGLE 405
>XP_006710142
          Length = 671

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SERDQAGLE 9
           SE+DQAGLE
Sbjct: 506 SEKDQAGLE 514
>XP_006710141
          Length = 672

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   SERDQAGLE 9
           SE+DQAGLE
Sbjct: 507 SEKDQAGLE 515
>NP_001239264
          Length = 1302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SE+DQAG E
Sbjct: 813 SEQDQAGTE 821
>NP_116255
          Length = 1302

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SE+DQAG E
Sbjct: 813 SEQDQAGTE 821
>XP_005254784
          Length = 1303

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SE+DQAG E
Sbjct: 813 SEQDQAGTE 821
>XP_005254783
          Length = 1303

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SE+DQAG E
Sbjct: 813 SEQDQAGTE 821
>NP_005251
          Length = 454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ERDQAGL 8
          ERD+AGL
Sbjct: 55 ERDRAGL 61
>NP_001073932
          Length = 4314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERDQAGLE 9
            E +QAGLE
Sbjct: 3110 ETEQAGLE 3117
>NP_001368
          Length = 4307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERDQAGLE 9
            E +QAGLE
Sbjct: 3110 ETEQAGLE 3117
>NP_004548
          Length = 2003

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    RDQAGL 8
            RDQAGL
Sbjct: 1796 RDQAGL 1801
>NP_060151
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SERDQAGL 8
           S RDQ+GL
Sbjct: 157 STRDQSGL 164
>XP_005257785
          Length = 1887

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RDQAGLE 9
           RDQ GLE
Sbjct: 450 RDQQGLE 456
>XP_006718966
          Length = 4300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERDQAGLE 9
            E +QAGLE
Sbjct: 3103 ETEQAGLE 3110
>NP_115510
          Length = 1663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RDQAGLE 9
           RDQ GLE
Sbjct: 284 RDQQGLE 290
>NP_149094
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDQAGLE 9
           RD+AG+E
Sbjct: 163 RDEAGVE 169
>NP_683721
          Length = 760

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SERDQAGL 8
           +ER QAGL
Sbjct: 554 AERGQAGL 561
>NP_003965
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           ++RD AGL+
Sbjct: 374 ADRDPAGLQ 382
>NP_001139806
          Length = 1562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERDQAGLE 9
            E D+AGLE
Sbjct: 1517 EVDEAGLE 1524
>NP_005986
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SERDQAGL 8
           ++RDQ GL
Sbjct: 355 ADRDQGGL 362
>XP_005256713
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    SERDQAGL 8
            SER++AG+
Sbjct: 1036 SEREEAGV 1043
>XP_006720059
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SER +AG+E
Sbjct: 589 SERCRAGME 597
>XP_006716474
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           ++RD AGL+
Sbjct: 220 ADRDPAGLQ 228
>XP_005273738
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           ++RD AGL+
Sbjct: 220 ADRDPAGLQ 228
>XP_005273737
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           ++RD AGL+
Sbjct: 280 ADRDPAGLQ 288
>XP_006715737
          Length = 1349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ERDQAGLE 9
            E D+AGLE
Sbjct: 1304 EVDEAGLE 1311
>XP_006710034
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SERDQAGLE 9
           SER +AG+E
Sbjct: 570 SERCRAGME 578
>NP_055673
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ERDQAGLE 9
          E D AGLE
Sbjct: 15 EEDGAGLE 22
>NP_001191344
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ERDQAG 7
           ERD+AG
Sbjct: 194 ERDEAG 199
>NP_001191343
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ERDQAG 7
           ERD+AG
Sbjct: 268 ERDEAG 273
>NP_114072
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RDQAGLE 9
          +D+AGLE
Sbjct: 62 QDEAGLE 68
>NP_071447
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ERDQAG 7
           ERD+AG
Sbjct: 299 ERDEAG 304
>NP_003459
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RDQAGLE 9
          +D+AGLE
Sbjct: 60 QDEAGLE 66
>NP_777614
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    SERDQAG 7
            SER++AG
Sbjct: 1036 SEREEAG 1042
>XP_006713148
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SERDQAG 7
           +E+DQAG
Sbjct: 669 NEQDQAG 675
>XP_005245743
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ERDQAGLE 9
          E D AGLE
Sbjct: 15 EEDGAGLE 22
>XP_005271164
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ERDQAG 7
           ERD+AG
Sbjct: 194 ERDEAG 199
>XP_005271163
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ERDQAG 7
           ERD+AG
Sbjct: 299 ERDEAG 304
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.120    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 592,927
Number of extensions: 955
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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