Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1135
XP_005266703                                                           18    1135
NP_001095272                                                           16    5631
NP_057705                                                              16    5631
NP_055052                                                              16    5631
XP_005253027                                                           16    5631
XP_006718311                                                           16    5631
XP_006718310                                                           16    5631
XP_005253024                                                           16    5631
XP_005253022                                                           16    5631
XP_005253021                                                           16    5631
XP_005253020                                                           16    5631
XP_005253019                                                           16    5631
NP_001136105                                                           16    7355
NP_001122099                                                           16    7355
NP_001122098                                                           16    7355
NP_689621                                                              16    7355
NP_055123                                                              16    7355
NP_001092741                                                           16    7355
NP_064533                                                              16    7355
NP_001238784                                                           16    7355
NP_001238780                                                           16    7355
NP_001238781                                                           16    7355
NP_001238782                                                           16    7355
XP_006722397                                                           16    7355
XP_005258179                                                           16    7355
XP_005258178                                                           16    7355
XP_006722396                                                           16    7355
XP_005256637                                                           16    7355
XP_005256636                                                           16    7355
XP_005248493                                                           16    7355
XP_005248492                                                           16    7355
NP_619542                                                              15    9605
NP_659475                                                              15    9605
NP_001273171                                                           15    9605
NP_001511                                                              15    9605
NP_001276065                                                           15    9605
NP_004778                                                              15    9605
NP_001276064                                                           15    9605
NP_001159430                                                           15    9605
NP_057278                                                              15    9605
NP_006569                                                              15    9605
NP_001035936                                                           15    9605
NP_079216                                                              15    9605
NP_001159431                                                           15    9605
NP_061000                                                              15    9605
XP_005274600                                                           15    9605
XP_005257568                                                           15    9605
XP_005257567                                                           15    9605
XP_005257565                                                           15    9605
XP_006722037                                                           15    9605
XP_006721105                                                           15    9605
XP_006716465                                                           15    9605
XP_005273707                                                           15    9605
XP_005248271                                                           15    9605
XP_005248268                                                           15    9605
>NP_443179
          Length = 2170

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SENRISTSQ 9
            SENRIS SQ
Sbjct: 1463 SENRISRSQ 1471
>XP_005266703
          Length = 1501

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SENRISTSQ 9
           SENRIS SQ
Sbjct: 794 SENRISRSQ 802
>NP_001095272
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>NP_057705
          Length = 634

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>NP_055052
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SENRISTS 8
           +EN+ISTS
Sbjct: 239 NENQISTS 246
>XP_005253027
          Length = 629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_006718311
          Length = 636

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 35 SENKLQTAQ 43
>XP_006718310
          Length = 649

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_005253024
          Length = 680

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_005253022
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_005253021
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_005253020
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>XP_005253019
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SENRISTSQ 9
          SEN++ T+Q
Sbjct: 80 SENKLQTAQ 88
>NP_001136105
          Length = 880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 793 NQISTSQ 799
>NP_001122099
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 303 ENGLSTSQ 310
>NP_001122098
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 437 ENGLSTSQ 444
>NP_689621
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SENRISTS 8
           S+NRIS+S
Sbjct: 473 SKNRISSS 480
>NP_055123
          Length = 880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 793 NQISTSQ 799
>NP_001092741
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SENRISTS 8
           S+NRIS+S
Sbjct: 498 SKNRISSS 505
>NP_064533
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 423 ENGLSTSQ 430
>NP_001238784
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 407 NQISTSQ 413
>NP_001238780
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 407 NQISTSQ 413
>NP_001238781
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 407 NQISTSQ 413
>NP_001238782
          Length = 494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 407 NQISTSQ 413
>XP_006722397
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ENRISTSQ 9
          EN +STSQ
Sbjct: 35 ENGLSTSQ 42
>XP_005258179
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 423 ENGLSTSQ 430
>XP_005258178
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 315 ENGLSTSQ 322
>XP_006722396
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ENRISTSQ 9
           EN +STSQ
Sbjct: 368 ENGLSTSQ 375
>XP_005256637
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 792 NQISTSQ 798
>XP_005256636
          Length = 880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NRISTSQ 9
           N+ISTSQ
Sbjct: 793 NQISTSQ 799
>XP_005248493
          Length = 547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SENRISTS 8
           S+NRIS+S
Sbjct: 470 SKNRISSS 477
>XP_005248492
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SENRISTS 8
           S+NRIS+S
Sbjct: 471 SKNRISSS 478
>NP_619542
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 426 SENRIS 431
>NP_659475
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ENRISTSQ 9
           EN + TSQ
Sbjct: 124 ENEVKTSQ 131
>NP_001273171
          Length = 2084

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NRISTSQ 9
           NR+ TSQ
Sbjct: 721 NRVKTSQ 727
>NP_001511
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NRISTSQ 9
           NR+ TSQ
Sbjct: 721 NRVKTSQ 727
>NP_001276065
          Length = 1521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SENRIST 7
           S NRIST
Sbjct: 777 SNNRIST 783
>NP_004778
          Length = 1529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SENRIST 7
           S NRIST
Sbjct: 785 SNNRIST 791
>NP_001276064
          Length = 1525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SENRIST 7
           S NRIST
Sbjct: 781 SNNRIST 787
>NP_001159430
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>NP_057278
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENRIST 7
           ENR+ST
Sbjct: 367 ENRVST 372
>NP_006569
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ENRIST 7
           ENR+ST
Sbjct: 325 ENRVST 330
>NP_001035936
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>NP_079216
          Length = 1870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SENRIS 6
            SENRIS
Sbjct: 1725 SENRIS 1730
>NP_001159431
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>NP_061000
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>XP_005274600
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 444 SENRIS 449
>XP_005257568
          Length = 224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>XP_005257567
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>XP_005257565
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>XP_006722037
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   SENRIS 6
           SENRIS
Sbjct: 121 SENRIS 126
>XP_006721105
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NRISTSQ 9
           NR+ TSQ
Sbjct: 721 NRVKTSQ 727
>XP_006716465
          Length = 1826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SENRIS 6
            SENRIS
Sbjct: 1725 SENRIS 1730
>XP_005273707
          Length = 1847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    SENRIS 6
            SENRIS
Sbjct: 1725 SENRIS 1730
>XP_005248271
          Length = 1404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SENRIST 7
           S NRIST
Sbjct: 660 SNNRIST 666
>XP_005248268
          Length = 1533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SENRIST 7
           S NRIST
Sbjct: 789 SNNRIST 795
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283   0.0969    0.211 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 384,757
Number of extensions: 530
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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