Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     390
NP_000170                                                              20     390
NP_001268422                                                           20     390
NP_001268423                                                           20     390
XP_005264328                                                           20     390
NP_001157413                                                           18    1482
NP_001171678                                                           18    1935
NP_775101                                                              18    1935
NP_006746                                                              18    1935
NP_001171679                                                           18    1935
XP_005262422                                                           18    1935
NP_036428                                                              17    2528
NP_536739                                                              17    2528
XP_006718816                                                           17    2528
XP_005276768                                                           17    4312
XP_005274690                                                           17    4312
XP_006711718                                                           17    4312
XP_006711717                                                           17    4312
XP_006711715                                                           17    4312
XP_006711714                                                           17    4312
XP_006711713                                                           17    4312
XP_006711712                                                           17    4312
XP_006711711                                                           17    4312
XP_006711710                                                           17    4312
XP_006711709                                                           17    4312
XP_006711708                                                           17    4312
XP_006711707                                                           17    4312
XP_006711706                                                           17    4312
XP_006711705                                                           17    4312
NP_001132962                                                           16    5631
NP_056465                                                              16    5631
NP_689842                                                              16    5631
NP_001035878                                                           16    5631
XP_006716794                                                           16    5631
XP_005251446                                                           16    5631
XP_005251445                                                           16    5631
XP_005251444                                                           16    5631
XP_005251443                                                           16    5631
XP_006712477                                                           16    5631
XP_006712475                                                           16    5631
NP_061338                                                              16    7355
NP_061337                                                              16    7355
NP_000434                                                              16    7355
NP_061893                                                              16    7355
NP_005112                                                              16    7355
NP_001004023                                                           16    7355
XP_006721758                                                           16    7355
XP_005257109                                                           16    7355
XP_005257107                                                           16    7355
XP_006721757                                                           16    7355
XP_005257106                                                           16    7355
XP_006711640                                                           16    7355
XP_005273372                                                           16    7355
XP_006711639                                                           16    7355
XP_005273373                                                           16    7355
NP_060626                                                              15    9605
NP_056193                                                              15    9605
NP_004504                                                              15    9605
NP_001165599                                                           15    9605
NP_757366                                                              15    9605
NP_002147                                                              15    9605
NP_955472                                                              15    9605
NP_001012779                                                           15    9605
NP_001026883                                                           15    9605
XP_005254403                                                           15    9605
XP_005254402                                                           15    9605
XP_005254401                                                           15    9605
XP_005254400                                                           15    9605
XP_005254399                                                           15    9605
XP_005272023                                                           15    9605
XP_005246575                                                           15    9605
XP_006711113                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           EKLSDGIG
Sbjct: 515 EKLSDGIG 522
>NP_000170
          Length = 1360

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           EKLSDGIG
Sbjct: 645 EKLSDGIG 652
>NP_001268422
          Length = 1058

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           EKLSDGIG
Sbjct: 343 EKLSDGIG 350
>NP_001268423
          Length = 1058

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           EKLSDGIG
Sbjct: 343 EKLSDGIG 350
>XP_005264328
          Length = 1261

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           EKLSDGIG
Sbjct: 546 EKLSDGIG 553
>NP_001157413
          Length = 1257

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EKLSDGIG 9
           +K+SDGIG
Sbjct: 172 DKISDGIG 179
>NP_001171678
          Length = 837

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDGI
Sbjct: 547 EKLSDGI 553
>NP_775101
          Length = 837

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDGI
Sbjct: 547 EKLSDGI 553
>NP_006746
          Length = 337

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDGI
Sbjct: 306 EKLSDGI 312
>NP_001171679
          Length = 837

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDGI
Sbjct: 547 EKLSDGI 553
>XP_005262422
          Length = 837

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDGI
Sbjct: 547 EKLSDGI 553
>NP_036428
          Length = 638

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEKLSDGIG 9
           +E +SDG+G
Sbjct: 385 AESMSDGVG 393
>NP_536739
          Length = 676

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEKLSDGIG 9
           +E +SDG+G
Sbjct: 423 AESMSDGVG 431
>XP_006718816
          Length = 638

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEKLSDGIG 9
           +E +SDG+G
Sbjct: 385 AESMSDGVG 393
>XP_005276768
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDG+
Sbjct: 139 EKLSDGM 145
>XP_005274690
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EKLSDGI 8
           EKLSDG+
Sbjct: 139 EKLSDGM 145
>XP_006711718
          Length = 1436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 1417 AESLSDGYG 1425
>XP_006711717
          Length = 2385

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2366 AESLSDGYG 2374
>XP_006711715
          Length = 2428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2409 AESLSDGYG 2417
>XP_006711714
          Length = 2429

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2410 AESLSDGYG 2418
>XP_006711713
          Length = 2432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2413 AESLSDGYG 2421
>XP_006711712
          Length = 2473

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2454 AESLSDGYG 2462
>XP_006711711
          Length = 2482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2463 AESLSDGYG 2471
>XP_006711710
          Length = 2494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2475 AESLSDGYG 2483
>XP_006711709
          Length = 2495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2476 AESLSDGYG 2484
>XP_006711708
          Length = 2512

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2493 AESLSDGYG 2501
>XP_006711707
          Length = 2553

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2534 AESLSDGYG 2542
>XP_006711706
          Length = 2591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2572 AESLSDGYG 2580
>XP_006711705
          Length = 2592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    SEKLSDGIG 9
            +E LSDG G
Sbjct: 2573 AESLSDGYG 2581
>NP_001132962
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEKLSDG 7
           S+KLSDG
Sbjct: 313 SKKLSDG 319
>NP_056465
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEKLSDG 7
           S+KLSDG
Sbjct: 313 SKKLSDG 319
>NP_689842
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LSDGIG 9
           LSDGIG
Sbjct: 153 LSDGIG 158
>NP_001035878
          Length = 930

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LSDGIG 9
           LSDGIG
Sbjct: 308 LSDGIG 313
>XP_006716794
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LSDGIG 9
           LSDGIG
Sbjct: 308 LSDGIG 313
>XP_005251446
          Length = 583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LSDGIG 9
           LSDGIG
Sbjct: 308 LSDGIG 313
>XP_005251445
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LSDGIG 9
          LSDGIG
Sbjct: 86 LSDGIG 91
>XP_005251444
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LSDGIG 9
          LSDGIG
Sbjct: 86 LSDGIG 91
>XP_005251443
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LSDGIG 9
           LSDGIG
Sbjct: 153 LSDGIG 158
>XP_006712477
          Length = 624

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEKLSDG 7
           S+KLSDG
Sbjct: 313 SKKLSDG 319
>XP_006712475
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEKLSDG 7
           S+KLSDG
Sbjct: 313 SKKLSDG 319
>NP_061338
          Length = 1232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KLSDGIG 9
           K+S+GIG
Sbjct: 183 KISEGIG 189
>NP_061337
          Length = 1286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KLSDGIG 9
           K+S+GIG
Sbjct: 183 KISEGIG 189
>NP_000434
          Length = 1279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KLSDGIG 9
           K+S+GIG
Sbjct: 183 KISEGIG 189
>NP_061893
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>NP_005112
          Length = 2174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEKLSDGI 8
            SEKLSD +
Sbjct: 1181 SEKLSDDL 1188
>NP_001004023
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EKLSDGI 8
          EKL DG+
Sbjct: 5  EKLGDGV 11
>XP_006721758
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>XP_005257109
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>XP_005257107
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>XP_006721757
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>XP_005257106
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EKL+ G+G
Sbjct: 162 EKLAQGLG 169
>XP_006711640
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EKLSDGI 8
          EKL DG+
Sbjct: 5  EKLGDGV 11
>XP_005273372
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EKLSDGI 8
          EKL DG+
Sbjct: 5  EKLGDGV 11
>XP_006711639
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EKLSDGI 8
          EKL DG+
Sbjct: 5  EKLGDGV 11
>XP_005273373
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  EKLSDGI 8
          EKL DG+
Sbjct: 5  EKLGDGV 11
>NP_060626
          Length = 4363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LSDGIG 9
            LSDG+G
Sbjct: 4091 LSDGLG 4096
>NP_056193
          Length = 4388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LSDGIG 9
            LSDG+G
Sbjct: 4116 LSDGLG 4121
>NP_004504
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EK+S G+G
Sbjct: 537 EKMSAGLG 544
>NP_001165599
          Length = 1331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EKLSDGIG 9
            EK+S G+G
Sbjct: 1237 EKMSAGLG 1244
>NP_757366
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EKLSDGIG 9
            EK+S G+G
Sbjct: 1238 EKMSAGLG 1245
>NP_002147
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLSDGI 8
           KLSDG+
Sbjct: 396 KLSDGV 401
>NP_955472
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLSDGI 8
           KLSDG+
Sbjct: 396 KLSDGV 401
>NP_001012779
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SEKLSDGIG 9
           SE++ DG G
Sbjct: 360 SERIDDGQG 368
>NP_001026883
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LSDGIG 9
          LSDG+G
Sbjct: 45 LSDGLG 50
>XP_005254403
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EK+S G+G
Sbjct: 537 EKMSAGLG 544
>XP_005254402
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EK+S G+G
Sbjct: 627 EKMSAGLG 634
>XP_005254401
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EKLSDGIG 9
           EK+S G+G
Sbjct: 628 EKMSAGLG 635
>XP_005254400
          Length = 1378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EKLSDGIG 9
            EK+S G+G
Sbjct: 1284 EKMSAGLG 1291
>XP_005254399
          Length = 1379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    EKLSDGIG 9
            EK+S G+G
Sbjct: 1285 EKMSAGLG 1292
>XP_005272023
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SEKLSDGIG 9
           SE++ DG G
Sbjct: 359 SERIDDGQG 367
>XP_005246575
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KLSDGI 8
           KLSDG+
Sbjct: 396 KLSDGV 401
>XP_006711113
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEKLSDGIG 9
           SE+LSD  G
Sbjct: 250 SERLSDQAG 258
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.131    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 614,514
Number of extensions: 992
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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