Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001093260                                                           17    4312
NP_001094101                                                           17    4312
NP_036466                                                              17    4312
XP_006714538                                                           17    4312
NP_775656                                                              16    5631
NP_002596                                                              16    5631
NP_001230066                                                           16    5631
XP_006720631                                                           16    5631
XP_006720630                                                           16    5631
XP_005254990                                                           16    5631
NP_689997                                                              16    7355
NP_065202                                                              16    7355
XP_006725017                                                           16    7355
XP_006711144                                                           16    7355
NP_001025031                                                           16    7355
NP_689991                                                              15    9605
NP_775771                                                              15    9605
NP_665739                                                              15    9605
NP_997054                                                              15    9605
NP_001181866                                                           15    9605
NP_055915                                                              15    9605
NP_001181867                                                           15    9605
NP_001229658                                                           15    9605
NP_001158238                                                           15    9605
NP_079174                                                              15    9605
NP_001277260                                                           15    9605
NP_060903                                                              15    9605
NP_001140160                                                           15    9605
NP_008816                                                              15    9605
NP_001017922                                                           15    9605
NP_065171                                                              15    9605
NP_061008                                                              15    9605
NP_001133                                                              15    9605
NP_001134                                                              15    9605
XP_006722969                                                           15    9605
XP_006722968                                                           15    9605
XP_005259703                                                           15    9605
XP_005256014                                                           15    9605
XP_006720466                                                           15    9605
XP_005254230                                                           15    9605
XP_006720465                                                           15    9605
XP_005254228                                                           15    9605
XP_006717822                                                           15    9605
XP_006717821                                                           15    9605
XP_005269749                                                           15    9605
XP_006717820                                                           15    9605
XP_006714307                                                           15    9605
XP_005262955                                                           15    9605
XP_005262954                                                           15    9605
XP_005262953                                                           15    9605
XP_005262950                                                           15    9605
XP_006712961                                                           15    9605
XP_006712960                                                           15    9605
XP_006712114                                                           15    9605
XP_006711300                                                           15    9605
XP_005245063                                                           15    9605
XP_005245062                                                           15    9605
XP_005245061                                                           15    9605
XP_005245060                                                           15    9605
XP_005245057                                                           15    9605
XP_005245058                                                           15    9605
XP_005245056                                                           15    9605
XP_006710376                                                           15    9605
XP_005270472                                                           15    9605
XP_006710207                                                           15    9605
NP_065081                                                              15    9605
NP_001035194                                                           15    9605
>NP_001093260
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEILTPL 7
           SE+LTPL
Sbjct: 427 SELLTPL 433
>NP_001094101
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SEILTPL 7
           SE+LTPL
Sbjct: 429 SELLTPL 435
>NP_036466
          Length = 2058

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EILTPLSM 9
           EILTPL++
Sbjct: 384 EILTPLNV 391
>XP_006714538
          Length = 2035

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EILTPLSM 9
           EILTPL++
Sbjct: 384 EILTPLNV 391
>NP_775656
          Length = 783

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 427 SNIITPISL 435
>NP_002596
          Length = 829

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 473 SNIITPISL 481
>NP_001230066
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 401 SNIITPISL 409
>XP_006720631
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 473 SNIITPISL 481
>XP_006720630
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 226 SNIITPISL 234
>XP_005254990
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           S I+TP+S+
Sbjct: 283 SNIITPISL 291
>NP_689997
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           EILTPL
Sbjct: 351 EILTPL 356
>NP_065202
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           EILTPL
Sbjct: 223 EILTPL 228
>XP_006725017
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           EILTPL
Sbjct: 183 EILTPL 188
>XP_006711144
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           EILTPL
Sbjct: 183 EILTPL 188
>NP_001025031
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 604 EVLTPLA 610
>NP_689991
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTPLSM 9
           I+TPL+M
Sbjct: 289 IITPLTM 295
>NP_775771
          Length = 1244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            E+LTP S
Sbjct: 1018 EVLTPFS 1024
>NP_665739
          Length = 1315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 804 ELLTPLA 810
>NP_997054
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>NP_001181866
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 890 ELLTPLA 896
>NP_055915
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>NP_001181867
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 837 ELLTPLA 843
>NP_001229658
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ILTPLS 8
           ILTPLS
Sbjct: 419 ILTPLS 424
>NP_001158238
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            EILTP S
Sbjct: 1459 EILTPTS 1465
>NP_079174
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           SEIL  LSM
Sbjct: 561 SEILDSLSM 569
>NP_001277260
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           SEIL  LSM
Sbjct: 517 SEILDSLSM 525
>NP_060903
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SEILTPLS 8
           S ILTP+S
Sbjct: 871 STILTPVS 878
>NP_001140160
          Length = 1321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SEILTPLS 8
           S ILTP+S
Sbjct: 871 STILTPVS 878
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            EILTP S
Sbjct: 2373 EILTPTS 2379
>NP_001017922
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SEILTPLSM 9
          +E+L PLS+
Sbjct: 46 AELLCPLSL 54
>NP_065171
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 185 EVLTPL 190
>NP_061008
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SEILTPLSM 9
          +E+L PLS+
Sbjct: 46 AELLCPLSL 54
>NP_001133
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  EILTPL 7
          E+LTPL
Sbjct: 34 EVLTPL 39
>NP_001134
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  EILTPL 7
          E+LTPL
Sbjct: 34 EVLTPL 39
>XP_006722969
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           SEIL  LSM
Sbjct: 517 SEILDSLSM 525
>XP_006722968
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           SEIL  LSM
Sbjct: 656 SEILDSLSM 664
>XP_005259703
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           SEIL  LSM
Sbjct: 698 SEILDSLSM 706
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            EILTP S
Sbjct: 2372 EILTPTS 2378
>XP_006720466
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EILTPLS 8
           E+LTP S
Sbjct: 949 EVLTPFS 955
>XP_005254230
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   EILTPLS 8
           E+LTP S
Sbjct: 949 EVLTPFS 955
>XP_006720465
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            E+LTP S
Sbjct: 1013 EVLTPFS 1019
>XP_005254228
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EILTPLS 8
            E+LTP S
Sbjct: 1024 EVLTPFS 1030
>XP_006717822
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006717821
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_005269749
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006717820
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 431 EVLTPL 436
>XP_006714307
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ILTPLS 8
           ILTPLS
Sbjct: 201 ILTPLS 206
>XP_005262955
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTPLSM 9
           I+TPL+M
Sbjct: 289 IITPLTM 295
>XP_005262954
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTPLSM 9
           I+TPL+M
Sbjct: 222 IITPLTM 228
>XP_005262953
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTPLSM 9
           I+TPL+M
Sbjct: 240 IITPLTM 246
>XP_005262950
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ILTPLSM 9
           I+TPL+M
Sbjct: 289 IITPLTM 295
>XP_006712961
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 168 STMYTPLSM 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 202 STMYTPLSM 210
>XP_006712960
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 182 STMYTPLSM 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 216 STMYTPLSM 224
>XP_006712114
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SEILTPLS 8
           S ILTP+S
Sbjct: 211 STILTPVS 218
>XP_006711300
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 837 ELLTPLA 843
>XP_005245063
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245062
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245061
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 846 ELLTPLA 852
>XP_005245060
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 890 ELLTPLA 896
>XP_005245057
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>XP_005245058
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>XP_005245056
          Length = 1410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EILTPLS 8
           E+LTPL+
Sbjct: 899 ELLTPLA 905
>XP_006710376
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SEILTPLSM 9
          +E+L PLS+
Sbjct: 46 AELLCPLSL 54
>XP_005270472
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SEILTPLSM 9
           +E+L PLS+
Sbjct: 107 AELLCPLSL 115
>XP_006710207
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 168 STMYTPLSM 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SEILTPLSM 9
           S + TPLSM
Sbjct: 202 STMYTPLSM 210
>NP_065081
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EILTPL 7
           E+LTPL
Sbjct: 431 EVLTPL 436
>NP_001035194
          Length = 4493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    SEILTPLSM 9
            SE+ TPL++
Sbjct: 3631 SEVSTPLTI 3639
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.125    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 632,732
Number of extensions: 983
Number of successful extensions: 70
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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