Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
NP_001159579                                                           17    3301
NP_005509                                                              17    3301
NP_001137448                                                           17    4312
NP_003381                                                              17    4312
XP_005253176                                                           17    4312
XP_005253175                                                           17    4312
NP_003213                                                              16    5631
NP_055415                                                              16    5631
NP_006786                                                              16    5631
NP_001269373                                                           16    5631
NP_001615                                                              16    5631
NP_937870                                                              16    5631
NP_937872                                                              16    5631
NP_001269374                                                           16    5631
XP_006718487                                                           16    5631
XP_005266896                                                           16    5631
XP_006713970                                                           16    5631
XP_006713968                                                           16    5631
NP_002917                                                              16    5631
NP_001257903                                                           16    7355
XP_006721269                                                           16    7355
XP_006718995                                                           16    7355
XP_005274425                                                           16    7355
XP_006718994                                                           16    7355
XP_006718993                                                           16    7355
XP_005274424                                                           16    7355
XP_005274423                                                           16    7355
NP_203753                                                              16    7355
NP_000161                                                              15    9605
NP_001240628                                                           15    9605
NP_872198                                                              15    9605
NP_056492                                                              15    9605
NP_004746                                                              15    9605
NP_001153069                                                           15    9605
NP_001240630                                                           15    9605
NP_001006600                                                           15    9605
NP_061165                                                              15    9605
NP_001240627                                                           15    9605
NP_001240626                                                           15    9605
XP_006714723                                                           15    9605
XP_005248613                                                           15    9605
XP_005248612                                                           15    9605
XP_005248611                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            SEE TEIIS
Sbjct: 2814 SEEVTEIIS 2822
>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            SEE TEIIS
Sbjct: 2806 SEEVTEIIS 2814
>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            SEE TEIIS
Sbjct: 2767 SEEVTEIIS 2775
>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            SEE TEIIS
Sbjct: 2846 SEEVTEIIS 2854
>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            SEE TEIIS
Sbjct: 2859 SEEVTEIIS 2867
>NP_001159579
          Length = 466

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EEFTEIIS 9
           EEFTEI++
Sbjct: 416 EEFTEIMN 423
>NP_005509
          Length = 508

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   EEFTEIIS 9
           EEFTEI++
Sbjct: 458 EEFTEIMN 465
>NP_001137448
          Length = 432

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EFTE++
Sbjct: 325 SQEFTELL 332
>NP_003381
          Length = 646

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EFTE++
Sbjct: 539 SQEFTELL 546
>XP_005253176
          Length = 433

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EFTE++
Sbjct: 325 SQEFTELL 332
>XP_005253175
          Length = 647

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EFTE++
Sbjct: 539 SQEFTELL 546
>NP_003213
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EEFTEIIS 9
           +EFTE++S
Sbjct: 360 KEFTELLS 367
>NP_055415
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_006786
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_001269373
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>NP_001615
          Length = 1723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EEFTEII 8
           E+FTEII
Sbjct: 698 EKFTEII 704
>NP_937870
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SEEFTEIIS 9
           +EEF E+IS
Sbjct: 539 AEEFFELIS 547
>NP_937872
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            +EEF E+IS
Sbjct: 1187 AEEFFELIS 1195
>NP_001269374
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EF+E+I
Sbjct: 211 SDEFSEVI 218
>XP_006718487
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   SEEFTEII 8
           S+EF+E+I
Sbjct: 197 SDEFSEVI 204
>XP_005266896
          Length = 2131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    EEFTEII 8
            E+FTEII
Sbjct: 1106 EKFTEII 1112
>XP_006713970
          Length = 646

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SEEFTEIIS 9
           +EEF E+IS
Sbjct: 386 AEEFFELIS 394
>XP_006713968
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            +EEF E+IS
Sbjct: 1187 AEEFFELIS 1195
>NP_002917
          Length = 1376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    SEEFTEIIS 9
            +EEF E+IS
Sbjct: 1187 AEEFFELIS 1195
>NP_001257903
          Length = 5121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EFTEII 8
            EFTEII
Sbjct: 3634 EFTEII 3639
>XP_006721269
          Length = 5138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    EFTEII 8
            EFTEII
Sbjct: 3651 EFTEII 3656
>XP_006718995
          Length = 2382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 1992 SEEHTEIL 1999
>XP_005274425
          Length = 2566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2177 SEEHTEIL 2184
>XP_006718994
          Length = 2567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2177 SEEHTEIL 2184
>XP_006718993
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2212 SEEHTEIL 2219
>XP_005274424
          Length = 2614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2225 SEEHTEIL 2232
>XP_005274423
          Length = 2615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2225 SEEHTEIL 2232
>NP_203753
          Length = 2601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    SEEFTEII 8
            SEE TEI+
Sbjct: 2212 SEEHTEIL 2219
>NP_000161
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   EEFTEII 8
           E+FTE++
Sbjct: 274 EDFTELV 280
>NP_001240628
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_872198
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SEEFTEI 7
           +EEFTE+
Sbjct: 349 AEEFTEM 355
>NP_056492
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EFTEIIS 9
          EFTEI S
Sbjct: 22 EFTEITS 28
>NP_004746
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   SEEFTEI 7
           +EEFTE+
Sbjct: 349 AEEFTEM 355
>NP_001153069
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EFTEIIS 9
          EFTEI S
Sbjct: 22 EFTEITS 28
>NP_001240630
          Length = 1367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001006600
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_061165
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001240627
          Length = 1346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>NP_001240626
          Length = 1412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_006714723
          Length = 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248613
          Length = 1391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248612
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
>XP_005248611
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SEEFTEI 7
           S EFTE+
Sbjct: 193 SNEFTEV 199
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.122    0.279 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 502,087
Number of extensions: 1101
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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