Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              18    1935
NP_653080                                                              18    1935
XP_005267292                                                           18    1935
XP_005267291                                                           18    1935
XP_005267290                                                           18    1935
NP_001161210                                                           17    4312
NP_065176                                                              17    4312
XP_006711674                                                           17    4312
XP_006711673                                                           17    4312
XP_006711672                                                           17    4312
XP_006711671                                                           17    4312
XP_006711670                                                           17    4312
XP_005245629                                                           17    4312
NP_004097                                                              16    5631
NP_055454                                                              16    5631
NP_077816                                                              16    5631
NP_001180308                                                           16    5631
NP_060329                                                              16    5631
XP_006723876                                                           16    5631
XP_006723875                                                           16    5631
XP_006723874                                                           16    5631
XP_006723873                                                           16    5631
XP_006723872                                                           16    5631
XP_005260273                                                           16    5631
XP_006723871                                                           16    5631
XP_006723870                                                           16    5631
XP_006723869                                                           16    5631
XP_005268318                                                           16    5631
NP_004861                                                              16    7355
NP_996790                                                              16    7355
XP_006721661                                                           16    7355
NP_619542                                                              15    9605
NP_002212                                                              15    9605
NP_055105                                                              15    9605
NP_997275                                                              15    9605
NP_612146                                                              15    9605
NP_001231776                                                           15    9605
XP_005274600                                                           15    9605
XP_006717089                                                           15    9605
XP_006717088                                                           15    9605
XP_005273177                                                           15    9605
>NP_005091
          Length = 1782

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDVPAVVLL 9
           SDVPAVV L
Sbjct: 841 SDVPAVVPL 849
>NP_653080
          Length = 1684

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDVPAVVLL 9
           SDVPAVV L
Sbjct: 743 SDVPAVVPL 751
>XP_005267292
          Length = 1677

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDVPAVVLL 9
           SDVPAVV L
Sbjct: 736 SDVPAVVPL 744
>XP_005267291
          Length = 1684

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDVPAVVLL 9
           SDVPAVV L
Sbjct: 743 SDVPAVVPL 751
>XP_005267290
          Length = 1782

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDVPAVVLL 9
           SDVPAVV L
Sbjct: 841 SDVPAVVPL 849
>NP_001161210
          Length = 1483

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1226 DVPLVILL 1233
>NP_065176
          Length = 1877

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1620 DVPLVILL 1627
>XP_006711674
          Length = 1385

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1128 DVPLVILL 1135
>XP_006711673
          Length = 1549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1292 DVPLVILL 1299
>XP_006711672
          Length = 1557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1300 DVPLVILL 1307
>XP_006711671
          Length = 2153

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1896 DVPLVILL 1903
>XP_006711670
          Length = 2161

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1904 DVPLVILL 1911
>XP_005245629
          Length = 2164

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVP V+LL
Sbjct: 1907 DVPLVILL 1914
>NP_004097
          Length = 86

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 VPAVVLL 9
         +PAVVLL
Sbjct: 2 IPAVVLL 8
>NP_055454
          Length = 1564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            D PAV+LL
Sbjct: 1358 DQPAVILL 1365
>NP_077816
          Length = 1499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVPA VLL
Sbjct: 1144 DVPANVLL 1151
>NP_001180308
          Length = 533

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 108 DVPWVVLL 115
>NP_060329
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 123 DVPWVVLL 130
>XP_006723876
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  DVPAVVLL 9
          DVP VVLL
Sbjct: 7  DVPWVVLL 14
>XP_006723875
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  DVPAVVLL 9
          DVP VVLL
Sbjct: 7  DVPWVVLL 14
>XP_006723874
          Length = 542

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 107 DVPWVVLL 114
>XP_006723873
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 122 DVPWVVLL 129
>XP_006723872
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 123 DVPWVVLL 130
>XP_005260273
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 123 DVPWVVLL 130
>XP_006723871
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 122 DVPWVVLL 129
>XP_006723870
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 123 DVPWVVLL 130
>XP_006723869
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVPAVVLL 9
           DVP VVLL
Sbjct: 123 DVPWVVLL 130
>XP_005268318
          Length = 1499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    DVPAVVLL 9
            DVPA VLL
Sbjct: 1144 DVPANVLL 1151
>NP_004861
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SDVPAVVL 8
           S+VPAVV+
Sbjct: 160 SNVPAVVV 167
>NP_996790
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   SDVPAVV 7
           SDVP VV
Sbjct: 123 SDVPGVV 129
>XP_006721661
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SDVPAVVL 8
           S+VPAVV+
Sbjct: 160 SNVPAVVV 167
>NP_619542
          Length = 1041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SDVPAVVL 8
           SDV AV+L
Sbjct: 824 SDVTAVIL 831
>NP_002212
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SDVPAVVL 8
           S++PAV++
Sbjct: 564 SNIPAVII 571
>NP_055105
          Length = 1098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SDVPAVVL 8
           +D+P VVL
Sbjct: 612 ADIPLVVL 619
>NP_997275
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VPAVVLL 9
          +PAVVLL
Sbjct: 6  LPAVVLL 12
>NP_612146
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  DVPAVV 7
          DVPAV+
Sbjct: 8  DVPAVI 13
>NP_001231776
          Length = 85

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VPAVVLL 9
          +PAVVLL
Sbjct: 6  LPAVVLL 12
>XP_005274600
          Length = 1059

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SDVPAVVL 8
           SDV AV+L
Sbjct: 842 SDVTAVIL 849
>XP_006717089
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SDVPAVVL 8
           +D+P VVL
Sbjct: 167 ADIPLVVL 174
>XP_006717088
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SDVPAVVL 8
           +D+P VVL
Sbjct: 538 ADIPLVVL 545
>XP_005273177
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   SDVPAVVL 8
           S++PAV++
Sbjct: 564 SNIPAVII 571
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.139    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 605,576
Number of extensions: 930
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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