Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           19     665
NP_000170                                                              19     665
NP_001268422                                                           19     665
NP_001268423                                                           19     665
XP_005264328                                                           19     665
NP_001258973                                                           16    7355
NP_001258989                                                           16    7355
NP_003152                                                              16    7355
NP_001258971                                                           16    7355
XP_006722072                                                           16    7355
XP_005276144                                                           16    7355
NP_000245                                                              15    9605
NP_001001132                                                           15    9605
NP_003015                                                              15    9605
NP_001005207                                                           15    9605
NP_056109                                                              15    9605
XP_005261083                                                           15    9605
XP_005261088                                                           15    9605
XP_005261084                                                           15    9605
XP_005257447                                                           15    9605
XP_005257446                                                           15    9605
XP_005257445                                                           15    9605
XP_005257444                                                           15    9605
XP_005257443                                                           15    9605
XP_005257442                                                           15    9605
XP_006711832                                                           15    9605
XP_005273200                                                           15    9605
XP_005273198                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SDRTMSGES 9
            SDR MSGES
Sbjct: 1050 SDRIMSGES 1058
>NP_000170
          Length = 1360

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SDRTMSGES 9
            SDR MSGES
Sbjct: 1180 SDRIMSGES 1188
>NP_001268422
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           SDR MSGES
Sbjct: 878 SDRIMSGES 886
>NP_001268423
          Length = 1058

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           SDR MSGES
Sbjct: 878 SDRIMSGES 886
>XP_005264328
          Length = 1261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SDRTMSGES 9
            SDR MSGES
Sbjct: 1081 SDRIMSGES 1089
>NP_001258973
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           D TMSGE+
Sbjct: 432 DVTMSGEA 439
>NP_001258989
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           D TMSGE+
Sbjct: 462 DVTMSGEA 469
>NP_003152
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           D TMSGE+
Sbjct: 485 DVTMSGEA 492
>NP_001258971
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           D TMSGE+
Sbjct: 462 DVTMSGEA 469
>XP_006722072
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           D TMSGE+
Sbjct: 282 DVTMSGEA 289
>XP_005276144
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  SDRTMSGES 9
          +DRT+S E+
Sbjct: 16 TDRTLSAET 24
>NP_000245
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           S RT+SG++
Sbjct: 232 SGRTLSGQT 240
>NP_001001132
          Length = 1220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DRTMSG 7
           D+TMSG
Sbjct: 233 DKTMSG 238
>NP_003015
          Length = 1721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DRTMSG 7
           D+TMSG
Sbjct: 233 DKTMSG 238
>NP_001005207
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>NP_056109
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>XP_005261083
          Length = 1716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DRTMSG 7
           D+TMSG
Sbjct: 233 DKTMSG 238
>XP_005261088
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DRTMSG 7
           D+TMSG
Sbjct: 233 DKTMSG 238
>XP_005261084
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DRTMSG 7
           D+TMSG
Sbjct: 233 DKTMSG 238
>XP_005257447
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>XP_005257446
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>XP_005257445
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>XP_005257444
          Length = 930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 519 EETMSGEN 526
>XP_005257443
          Length = 939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 519 EETMSGEN 526
>XP_005257442
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   DRTMSGES 9
           + TMSGE+
Sbjct: 553 EETMSGEN 560
>XP_006711832
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           S RT+SG++
Sbjct: 232 SGRTLSGQT 240
>XP_005273200
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           S RT+SG++
Sbjct: 232 SGRTLSGQT 240
>XP_005273198
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SDRTMSGES 9
           S RT+SG++
Sbjct: 231 SGRTLSGQT 239
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.288    0.104    0.251 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 617,796
Number of extensions: 1585
Number of successful extensions: 28
Number of sequences better than 10000.0: 28
Number of HSP's gapped: 28
Number of HSP's successfully gapped: 28
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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