Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_001487                                                              17    2528
NP_976221                                                              17    3301
NP_001230829                                                           17    3301
NP_005327                                                              17    3301
NP_742024                                                              17    3301
NP_115937                                                              17    3301
XP_006715613                                                           17    3301
XP_006713835                                                           17    3301
XP_006713834                                                           17    3301
XP_006713832                                                           17    3301
XP_006713831                                                           17    3301
XP_006712539                                                           17    3301
XP_005247059                                                           17    3301
XP_005247058                                                           17    3301
XP_006712538                                                           17    3301
XP_005247060                                                           17    3301
XP_005247057                                                           17    3301
NP_060228                                                              17    3301
NP_001177317                                                           16    5631
NP_001159864                                                           16    5631
NP_006661                                                              16    5631
XP_005248820                                                           16    5631
NP_569055                                                              16    7355
NP_001449                                                              16    7355
NP_001120959                                                           16    7355
NP_115542                                                              16    7355
NP_001130038                                                           16    7355
NP_001257951                                                           16    7355
NP_001257952                                                           16    7355
NP_579878                                                              16    7355
NP_015627                                                              16    7355
NP_579890                                                              16    7355
NP_579889                                                              16    7355
NP_579877                                                              16    7355
NP_001035889                                                           16    7355
NP_476516                                                              16    7355
XP_006723668                                                           16    7355
XP_006723667                                                           16    7355
XP_006723666                                                           16    7355
XP_006723665                                                           16    7355
XP_005254442                                                           16    7355
XP_006715973                                                           16    7355
XP_005263293                                                           16    7355
XP_006713977                                                           16    7355
XP_005248062                                                           16    7355
XP_005248059                                                           16    7355
XP_005248058                                                           16    7355
NP_002364                                                              16    7355
NP_001157790                                                           15    9605
NP_996895                                                              15    9605
NP_036227                                                              15    9605
NP_653212                                                              15    9605
NP_001157791                                                           15    9605
NP_001157789                                                           15    9605
NP_001448                                                              15    9605
XP_006719198                                                           15    9605
XP_006717827                                                           15    9605
XP_006717826                                                           15    9605
XP_006713130                                                           15    9605
XP_005265039                                                           15    9605
XP_005265038                                                           15    9605
XP_005265035                                                           15    9605
XP_005265034                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SDCSEAAKQ 9
            SD SEAAKQ
Sbjct: 2963 SDYSEAAKQ 2971
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SDCSEAAKQ 9
            SD SEAAKQ
Sbjct: 2963 SDYSEAAKQ 2971
>NP_001487
          Length = 400

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SDCSEAAKQ 9
          +DC EAA+Q
Sbjct: 84 ADCLEAAQQ 92
>NP_976221
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>NP_001230829
          Length = 1235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 821 DCVEAAKK 828
>NP_005327
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>NP_742024
          Length = 478

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SDCSEAAKQ 9
           SDC   AKQ
Sbjct: 186 SDCERLAKQ 194
>NP_115937
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SDCSEAAKQ 9
          SDC   AKQ
Sbjct: 44 SDCERLAKQ 52
>XP_006715613
          Length = 796

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  DCSEAA 7
          DCSEAA
Sbjct: 25 DCSEAA 30
>XP_006713835
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  SDCSEAAKQ 9
          SDC   AKQ
Sbjct: 44 SDCERLAKQ 52
>XP_006713834
          Length = 458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SDCSEAAKQ 9
           SDC   AKQ
Sbjct: 166 SDCERLAKQ 174
>XP_006713832
          Length = 480

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SDCSEAAKQ 9
           SDC   AKQ
Sbjct: 188 SDCERLAKQ 196
>XP_006713831
          Length = 509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   SDCSEAAKQ 9
           SDC   AKQ
Sbjct: 217 SDCERLAKQ 225
>XP_006712539
          Length = 1250

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>XP_005247059
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>XP_005247058
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>XP_006712538
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>XP_005247060
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>XP_005247057
          Length = 1268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DCSEAAKQ 9
           DC EAAK+
Sbjct: 854 DCVEAAKK 861
>NP_060228
          Length = 394

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           DCSEAA
Sbjct: 377 DCSEAA 382
>NP_001177317
          Length = 717

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  DCSEAAK 8
          DCS AAK
Sbjct: 5  DCSVAAK 11
>NP_001159864
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DCSEAAK 8
          +CSEAA+
Sbjct: 67 ECSEAAR 73
>NP_006661
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DCSEAAK 8
          +CSEAA+
Sbjct: 67 ECSEAAR 73
>XP_005248820
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  DCSEAAK 8
          +CSEAA+
Sbjct: 67 ECSEAAR 73
>NP_569055
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SDCSEAA 7
           +DC EAA
Sbjct: 766 TDCEEAA 772
>NP_001449
          Length = 2725

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DCSEAAK 8
           DCSEA +
Sbjct: 790 DCSEAGQ 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    DCSEAAK 8
            DCSEA +
Sbjct: 1179 DCSEAGE 1185
>NP_001120959
          Length = 2692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DCSEAAK 8
           DCSEA +
Sbjct: 790 DCSEAGQ 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    DCSEAAK 8
            DCSEA +
Sbjct: 1179 DCSEAGE 1185
>NP_115542
          Length = 764

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SDCSEAA 7
           +DC EAA
Sbjct: 739 TDCEEAA 745
>NP_001130038
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SDCSEA 6
          +DCSEA
Sbjct: 76 ADCSEA 81
>NP_001257951
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SDCSEAA 7
           +DC EAA
Sbjct: 639 TDCEEAA 645
>NP_001257952
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   SDCSEAA 7
           +DC EAA
Sbjct: 673 TDCEEAA 679
>NP_579878
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_015627
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_579890
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_579889
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_579877
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_001035889
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_476516
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DCSEAAK 8
           DC EAA+
Sbjct: 816 DCKEAAE 822
>XP_006723668
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SDCSEA 6
          +DCSEA
Sbjct: 76 ADCSEA 81
>XP_006723667
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SDCSEA 6
          +DCSEA
Sbjct: 76 ADCSEA 81
>XP_006723666
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SDCSEA 6
          +DCSEA
Sbjct: 76 ADCSEA 81
>XP_006723665
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SDCSEA 6
          +DCSEA
Sbjct: 76 ADCSEA 81
>XP_005254442
          Length = 3041

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DCSEAAKQ 9
            +CSEAA +
Sbjct: 2576 ECSEAATE 2583
>XP_006715973
          Length = 2632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DCSEAAK 8
           DCSEA +
Sbjct: 790 DCSEAGQ 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    DCSEAAK 8
            DCSEA +
Sbjct: 1086 DCSEAGE 1092
>XP_005263293
          Length = 865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DCSEAAK 8
           DC EAA+
Sbjct: 815 DCKEAAE 821
>XP_006713977
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>XP_005248062
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>XP_005248059
          Length = 1296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>XP_005248058
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   CSEAAKQ 9
           C E+AKQ
Sbjct: 294 CQESAKQ 300
>NP_002364
          Length = 2803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DCSEAAKQ 9
            +CSEAA +
Sbjct: 2338 ECSEAATE 2345
>NP_001157790
          Length = 2591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>NP_996895
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           +CSEAA
Sbjct: 96  ECSEAA 101
>NP_036227
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           +CSEAA
Sbjct: 96  ECSEAA 101
>NP_653212
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2  DCSEA 6
          DCSEA
Sbjct: 95 DCSEA 99
>NP_001157791
          Length = 2578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>NP_001157789
          Length = 2633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>NP_001448
          Length = 2602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>XP_006719198
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           +CSEAA
Sbjct: 173 ECSEAA 178
>XP_006717827
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           +CSEAA
Sbjct: 96  ECSEAA 101
>XP_006717826
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   DCSEAA 7
           +CSEAA
Sbjct: 96  ECSEAA 101
>XP_006713130
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>XP_005265039
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>XP_005265038
          Length = 2181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>XP_005265035
          Length = 2609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
>XP_005265034
          Length = 2622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    DCSEA 6
            DCSEA
Sbjct: 1157 DCSEA 1161
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.103    0.275 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 567,234
Number of extensions: 438
Number of successful extensions: 68
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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