Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1935
NP_671714                                                              18    1935
XP_006715890                                                           18    1935
XP_005250160                                                           18    1935
XP_005250159                                                           18    1935
NP_060004                                                              17    3301
NP_001093582                                                           17    3301
NP_149022                                                              17    4312
NP_001122405                                                           16    5631
NP_001122406                                                           16    5631
NP_001273683                                                           16    5631
NP_597734                                                              16    5631
NP_002463                                                              16    5631
NP_004378                                                              16    7355
NP_055510                                                              16    7355
NP_001274359                                                           16    7355
NP_490595                                                              16    7355
NP_001274355                                                           16    7355
NP_001274358                                                           16    7355
NP_003355                                                              16    7355
NP_001274357                                                           16    7355
XP_005256934                                                           16    7355
XP_006721670                                                           16    7355
XP_005249895                                                           16    7355
XP_005265877                                                           16    7355
XP_005263887                                                           16    7355
NP_001232                                                              16    7355
NP_001181926                                                           15    9605
NP_001014437                                                           15    9605
NP_258416                                                              15    9605
NP_203134                                                              15    9605
NP_203133                                                              15    9605
NP_005705                                                              15    9605
XP_006725192                                                           15    9605
XP_006723736                                                           15    9605
XP_006718403                                                           15    9605
>NP_005742
          Length = 3907

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SCRLQAAVE 9
            S RLQAAVE
Sbjct: 1847 SSRLQAAVE 1855
>NP_671714
          Length = 3899

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SCRLQAAVE 9
            S RLQAAVE
Sbjct: 1847 SSRLQAAVE 1855
>XP_006715890
          Length = 3860

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SCRLQAAVE 9
            S RLQAAVE
Sbjct: 1800 SSRLQAAVE 1808
>XP_005250160
          Length = 3939

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SCRLQAAVE 9
            S RLQAAVE
Sbjct: 1879 SSRLQAAVE 1887
>XP_005250159
          Length = 3952

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SCRLQAAVE 9
            S RLQAAVE
Sbjct: 1879 SSRLQAAVE 1887
>NP_060004
          Length = 1941

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    CRLQAAVE 9
            C LQAA+E
Sbjct: 1544 CELQAALE 1551
>NP_001093582
          Length = 1941

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    CRLQAAVE 9
            C LQAA+E
Sbjct: 1544 CELQAALE 1551
>NP_149022
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   CRLQAAVE 9
           C LQAA+E
Sbjct: 195 CSLQAALE 202
>NP_001122405
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CRLQAAVE 9
           CRLQA  E
Sbjct: 299 CRLQAGKE 306
>NP_001122406
          Length = 1109

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CRLQAAVE 9
           CRLQA  E
Sbjct: 299 CRLQAGKE 306
>NP_001273683
          Length = 1230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CRLQAAVE 9
           CRLQA  E
Sbjct: 268 CRLQAGKE 275
>NP_597734
          Length = 1261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CRLQAAVE 9
           CRLQA  E
Sbjct: 299 CRLQAGKE 306
>NP_002463
          Length = 1937

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CRLQAAVE 9
            C +QAA+E
Sbjct: 1541 CEIQAALE 1548
>NP_004378
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CRLQAAVE 9
           C LQ AVE
Sbjct: 114 CALQKAVE 121
>NP_055510
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CRLQAAV 8
           CRL AAV
Sbjct: 918 CRLAAAV 924
>NP_001274359
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 123 ACGLQAAV 130
>NP_490595
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SCRLQAA 7
          SCR QAA
Sbjct: 35 SCRQQAA 41
>NP_001274355
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 260 ACGLQAAV 267
>NP_001274358
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 123 ACGLQAAV 130
>NP_003355
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 260 ACGLQAAV 267
>NP_001274357
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 123 ACGLQAAV 130
>XP_005256934
          Length = 1434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CRLQAAV 8
           CRL AAV
Sbjct: 918 CRLAAAV 924
>XP_006721670
          Length = 1471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CRLQAAV 8
           CRL AAV
Sbjct: 918 CRLAAAV 924
>XP_005249895
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SCRLQAAV 8
           +C LQAAV
Sbjct: 196 ACGLQAAV 203
>XP_005265877
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  CRLQAAVE 9
          C LQ AVE
Sbjct: 76 CALQKAVE 83
>XP_005263887
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SCRLQAA 7
          SCR QAA
Sbjct: 35 SCRQQAA 41
>NP_001232
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SCRLQAA 7
          SCR QAA
Sbjct: 35 SCRQQAA 41
>NP_001181926
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRLQAA 7
          CRLQA+
Sbjct: 87 CRLQAS 92
>NP_001014437
          Length = 831

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRLQAA 7
          CRLQA+
Sbjct: 87 CRLQAS 92
>NP_258416
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SCRLQA 6
          +CRLQA
Sbjct: 36 ACRLQA 41
>NP_203134
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SCRLQA 6
          +CRLQA
Sbjct: 36 ACRLQA 41
>NP_203133
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SCRLQA 6
          +CRLQA
Sbjct: 36 ACRLQA 41
>NP_005705
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  SCRLQA 6
          +CRLQA
Sbjct: 36 ACRLQA 41
>XP_006725192
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRLQAA 7
          CRLQA+
Sbjct: 87 CRLQAS 92
>XP_006723736
          Length = 215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   CRLQAA 7
           CRLQA+
Sbjct: 189 CRLQAS 194
>XP_006718403
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  CRLQAA 7
          CRLQA+
Sbjct: 87 CRLQAS 92
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.121    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 461,852
Number of extensions: 420
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package