Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              21     229
XP_006713721                                                           21     229
NP_078853                                                              17    3301
NP_002664                                                              17    3301
NP_001123554                                                           17    3301
XP_006713269                                                           17    3301
NP_055467                                                              17    4312
NP_057635                                                              17    4312
NP_001193602                                                           17    4312
NP_001103467                                                           17    4312
XP_005267404                                                           17    4312
XP_005253448                                                           17    4312
XP_003846672                                                           17    4312
NP_001271426                                                           16    5631
NP_114428                                                              16    5631
XP_006723775                                                           16    5631
XP_006723774                                                           16    5631
XP_006723773                                                           16    5631
XP_005255680                                                           16    5631
XP_006721020                                                           16    5631
XP_005255679                                                           16    5631
XP_006721019                                                           16    5631
NP_001138822                                                           16    5631
NP_054706                                                              16    7355
NP_003364                                                              16    7355
NP_075391                                                              16    7355
NP_006662                                                              16    7355
NP_001274524                                                           16    7355
NP_001274526                                                           16    7355
NP_110400                                                              16    7355
NP_039663                                                              16    7355
NP_000150                                                              16    7355
NP_116228                                                              16    7355
NP_001258867                                                           16    7355
NP_001401                                                              16    7355
XP_006726267                                                           16    7355
XP_005276792                                                           16    7355
XP_006722784                                                           16    7355
XP_006722783                                                           16    7355
XP_005270200                                                           16    7355
XP_005270199                                                           16    7355
XP_006711553                                                           16    7355
XP_005245516                                                           16    7355
NP_001004481                                                           16    7355
NP_001001956                                                           16    7355
NP_705839                                                              15    9605
NP_001154926                                                           15    9605
NP_001154924                                                           15    9605
NP_001005783                                                           15    9605
NP_061859                                                              15    9605
NP_057611                                                              15    9605
XP_006718529                                                           15    9605
XP_006718528                                                           15    9605
XP_006718527                                                           15    9605
XP_006713954                                                           15    9605
XP_006713953                                                           15    9605
XP_006713952                                                           15    9605
XP_005248031                                                           15    9605
XP_006713951                                                           15    9605
XP_005270974                                                           15    9605
XP_005270973                                                           15    9605
XP_005270972                                                           15    9605
XP_005270971                                                           15    9605
XP_005270970                                                           15    9605
XP_006710015                                                           15    9605
XP_006710014                                                           15    9605
XP_005275768                                                           15    9605
NP_001001961                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SCIMLGRM 8
           SCIMLGRM
Sbjct: 275 SCIMLGRM 282
>XP_006713721
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SCIMLGRM 8
           SCIMLGRM
Sbjct: 275 SCIMLGRM 282
>NP_078853
          Length = 1288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C +LGR+S
Sbjct: 531 CFLLGRLS 538
>NP_002664
          Length = 2135

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LGR S
Sbjct: 502 CVLLGRCS 509
>NP_001123554
          Length = 2135

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LGR S
Sbjct: 502 CVLLGRCS 509
>XP_006713269
          Length = 2052

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LGR S
Sbjct: 419 CVLLGRCS 426
>NP_055467
          Length = 963

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C MLGRM
Sbjct: 728 CEMLGRM 734
>NP_057635
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SCIMLGRMS 9
           SC  LGR+S
Sbjct: 285 SCASLGRVS 293
>NP_001193602
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  SCIMLGR 7
          SC MLGR
Sbjct: 40 SCSMLGR 46
>NP_001103467
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CIMLGRMS 9
           C+  GRMS
Sbjct: 161 CVRFGRMS 168
>XP_005267404
          Length = 797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CIMLGRMS 9
           C+  GRMS
Sbjct: 425 CVRFGRMS 432
>XP_005253448
          Length = 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SCIMLGRMS 9
           SC  LGR+S
Sbjct: 285 SCASLGRVS 293
>XP_003846672
          Length = 830

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C MLGRM
Sbjct: 728 CEMLGRM 734
>NP_001271426
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 175 ACILVGRPS 183
>NP_114428
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 175 ACILVGRPS 183
>XP_006723775
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SCIMLGR 7
           +C++LGR
Sbjct: 136 TCVLLGR 142
>XP_006723774
          Length = 99

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  SCIMLGR 7
          +C++LGR
Sbjct: 32 TCVLLGR 38
>XP_006723773
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SCIMLGR 7
           +C++LGR
Sbjct: 136 TCVLLGR 142
>XP_005255680
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 166 ACILVGRPS 174
>XP_006721020
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 175 ACILVGRPS 183
>XP_005255679
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 175 ACILVGRPS 183
>XP_006721019
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +CI++GR S
Sbjct: 175 ACILVGRPS 183
>NP_001138822
          Length = 202

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   SCIMLGR 7
           +C++LGR
Sbjct: 136 TCVLLGR 142
>NP_054706
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +C MLG+M+
Sbjct: 324 TCKMLGQMT 332
>NP_003364
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +C MLG+M+
Sbjct: 324 TCKMLGQMT 332
>NP_075391
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CIMLGR 7
           C+M+GR
Sbjct: 247 CLMIGR 252
>NP_006662
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IMLGRM 8
           IMLGRM
Sbjct: 234 IMLGRM 239
>NP_001274524
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IMLGRM 8
           IMLGRM
Sbjct: 234 IMLGRM 239
>NP_001274526
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IMLGRM 8
           IMLGRM
Sbjct: 162 IMLGRM 167
>NP_110400
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   SCIMLGRMS 9
           +CI  G+MS
Sbjct: 314 ACIFRGKMS 322
>NP_039663
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           +C+ LGR+
Sbjct: 349 ACLQLGRL 356
>NP_000150
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           +C+ LGR+
Sbjct: 349 ACLQLGRL 356
>NP_116228
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   SCIMLG 6
           SCI+LG
Sbjct: 385 SCILLG 390
>NP_001258867
          Length = 2845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           SC+ LGR+
Sbjct: 601 SCLGLGRL 608
>NP_001401
          Length = 2778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           SC+ LGR+
Sbjct: 601 SCLGLGRL 608
>XP_006726267
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CIMLGR 7
           C+M+GR
Sbjct: 192 CLMIGR 197
>XP_005276792
          Length = 1108

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CIMLGR 7
           C+M+GR
Sbjct: 247 CLMIGR 252
>XP_006722784
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           +C+ LGR+
Sbjct: 349 ACLQLGRL 356
>XP_006722783
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   SCIMLGRM 8
           +C+ LGR+
Sbjct: 349 ACLQLGRL 356
>XP_005270200
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +C MLG+M+
Sbjct: 325 TCKMLGQMT 333
>XP_005270199
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SCIMLGRMS 9
           +C MLG+M+
Sbjct: 325 TCKMLGQMT 333
>XP_006711553
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CIMLGR 7
           C+M+GR
Sbjct: 192 CLMIGR 197
>XP_005245516
          Length = 1108

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   CIMLGR 7
           C+M+GR
Sbjct: 247 CLMIGR 252
>NP_001004481
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LG M+
Sbjct: 112 CVLLGMMA 119
>NP_001001956
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LG M+
Sbjct: 112 CVLLGMMA 119
>NP_705839
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 9  SCLLLGSL 16
>NP_001154926
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 26 SCLLLGSL 33
>NP_001154924
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 9  SCLLLGSL 16
>NP_001005783
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 296 CIFLGR 301
>NP_061859
          Length = 1336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 563 CFLLGRL 569
>NP_057611
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 296 CIFLGR 301
>XP_006718529
          Length = 135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 9  SCLLLGSL 16
>XP_006718528
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 9  SCLLLGSL 16
>XP_006718527
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  SCIMLGRM 8
          SC++LG +
Sbjct: 9  SCLLLGSL 16
>XP_006713954
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 270 CFLLGRL 276
>XP_006713953
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 270 CFLLGRL 276
>XP_006713952
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 392 CFLLGRL 398
>XP_005248031
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 487 CFLLGRL 493
>XP_006713951
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           C +LGR+
Sbjct: 536 CFLLGRL 542
>XP_005270974
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 239 CIFLGR 244
>XP_005270973
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 239 CIFLGR 244
>XP_005270972
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 309 CIFLGR 314
>XP_005270971
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 284 CIFLGR 289
>XP_005270970
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   CIMLGR 7
           CI LGR
Sbjct: 309 CIFLGR 314
>XP_006710015
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           CI+LG M
Sbjct: 255 CILLGGM 261
>XP_006710014
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           CI+LG M
Sbjct: 255 CILLGGM 261
>XP_005275768
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CIMLGRM 8
           CI+LG M
Sbjct: 504 CILLGGM 510
>NP_001001961
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   CIMLGRMS 9
           C++LG M+
Sbjct: 142 CLLLGMMA 149
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.137    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 536,346
Number of extensions: 944
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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