Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001234                                                              17    3301
NP_001268359                                                           17    3301
NP_056007                                                              17    3301
NP_001177396                                                           17    3301
XP_006711112                                                           17    3301
NP_055055                                                              17    4312
NP_001106674                                                           16    5631
XP_006719480                                                           16    5631
XP_006719479                                                           16    5631
XP_006719478                                                           16    5631
XP_006719477                                                           16    5631
XP_006719476                                                           16    5631
XP_006719475                                                           16    5631
NP_000115                                                              16    7355
NP_000669                                                              16    7355
NP_001116848                                                           16    7355
NP_542401                                                              16    7355
NP_002115                                                              15    9605
NP_001035987                                                           15    9605
NP_004806                                                              15    9605
NP_001269668                                                           15    9605
NP_110385                                                              15    9605
XP_006724266                                                           15    9605
XP_005261522                                                           15    9605
XP_006723282                                                           15    9605
XP_006711111                                                           15    9605
>NP_001234
          Length = 595

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SAPLALSS 8
           SAP+ALSS
Sbjct: 369 SAPVALSS 376
>NP_001268359
          Length = 483

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SAPLALSS 8
           SAP+ALSS
Sbjct: 258 SAPVALSS 265
>NP_056007
          Length = 1216

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    SAPLALSS 8
            SAPL+LSS
Sbjct: 1181 SAPLSLSS 1188
>NP_001177396
          Length = 1346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   APLALSSL 9
           +PLALSSL
Sbjct: 604 SPLALSSL 611
>XP_006711112
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   SAPLALSS 8
           SAP+ALSS
Sbjct: 320 SAPVALSS 327
>NP_055055
          Length = 676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   SAPLALS 7
           SAPLALS
Sbjct: 298 SAPLALS 304
>NP_001106674
          Length = 925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719480
          Length = 2035

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719479
          Length = 2059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719478
          Length = 2078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719477
          Length = 2082

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719476
          Length = 2082

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>XP_006719475
          Length = 2082

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           SAPLAL +L
Sbjct: 134 SAPLALVAL 142
>NP_000115
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    SAPLALSSL 9
            S PLA SSL
Sbjct: 1381 SGPLASSSL 1389
>NP_000669
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   APLALSSL 9
           APLAL++L
Sbjct: 460 APLALTAL 467
>NP_001116848
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   APLALSSL 9
           APL LSSL
Sbjct: 262 APLFLSSL 269
>NP_542401
          Length = 324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SAPLALSSL 9
          +AP ALS+L
Sbjct: 86 AAPFALSAL 94
>NP_002115
          Length = 266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  SAPLALS 7
          S+PLALS
Sbjct: 23 SSPLALS 29
>NP_001035987
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   APLALSS 8
           APLALS+
Sbjct: 230 APLALST 236
>NP_004806
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           +AP+ +SSL
Sbjct: 857 TAPITISSL 865
>NP_001269668
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SAPLALSSL 9
           SAPLAL  L
Sbjct: 174 SAPLALLPL 182
>NP_110385
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SAPLALSSL 9
           SAPLAL  L
Sbjct: 174 SAPLALLPL 182
>XP_006724266
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SAPLALSSL 9
           SAPLAL  L
Sbjct: 136 SAPLALLPL 144
>XP_005261522
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   SAPLALSSL 9
           SAPLAL  L
Sbjct: 174 SAPLALLPL 182
>XP_006723282
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   APLALSS 8
           APLALS+
Sbjct: 230 APLALST 236
>XP_006711111
          Length = 1197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SAPLALSSL 9
           +AP+ +SSL
Sbjct: 793 TAPITISSL 801
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.115    0.274 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 565,653
Number of extensions: 1117
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package