Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_067047                                                              17    2528
XP_006717281                                                           17    2528
XP_006717280                                                           17    2528
XP_006717279                                                           17    2528
XP_006717278                                                           17    2528
XP_006717277                                                           17    2528
XP_006717276                                                           17    2528
XP_006717275                                                           17    2528
XP_006717274                                                           17    2528
XP_006717273                                                           17    2528
XP_006717272                                                           17    2528
NP_005076                                                              17    3301
XP_005272276                                                           17    3301
XP_005272275                                                           17    3301
XP_005272273                                                           17    3301
NP_001129521                                                           17    4312
NP_149018                                                              17    4312
NP_001138863                                                           16    5631
NP_060367                                                              16    5631
NP_001252538                                                           16    5631
NP_001036111                                                           16    5631
NP_005564                                                              16    5631
NP_055780                                                              16    5631
NP_001252537                                                           16    5631
XP_006713280                                                           16    5631
XP_006713279                                                           16    5631
XP_006713092                                                           16    5631
XP_005265019                                                           16    5631
XP_005265017                                                           16    5631
XP_005265016                                                           16    5631
XP_005265015                                                           16    5631
XP_005265014                                                           16    5631
NP_001070865                                                           16    7355
NP_892017                                                              16    7355
XP_006710008                                                           16    7355
NP_078966                                                              15    9605
NP_001180451                                                           15    9605
NP_001180453                                                           15    9605
NP_001180452                                                           15    9605
NP_078795                                                              15    9605
NP_689678                                                              15    9605
XP_006723004                                                           15    9605
XP_005257989                                                           15    9605
XP_006721787                                                           15    9605
XP_005257987                                                           15    9605
XP_005257986                                                           15    9605
XP_005257985                                                           15    9605
XP_006721786                                                           15    9605
XP_005257984                                                           15    9605
XP_006721333                                                           15    9605
XP_006721332                                                           15    9605
NP_112217                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SAMATSTPI 9
            S+MATSTPI
Sbjct: 1502 SSMATSTPI 1510
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    SAMATSTPI 9
            S+MATSTPI
Sbjct: 1297 SSMATSTPI 1305
>NP_067047
          Length = 2506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717281
          Length = 1702

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717280
          Length = 2221

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717279
          Length = 2506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717278
          Length = 2566

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717277
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717276
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717275
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717274
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717273
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>XP_006717272
          Length = 2567

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           MATSTP+
Sbjct: 988 MATSTPV 994
>NP_005076
          Length = 2090

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 592 TAAATSTPV 600
>XP_005272276
          Length = 2036

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 537 TAAATSTPV 545
>XP_005272275
          Length = 2083

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 633 TAAATSTPV 641
>XP_005272273
          Length = 2132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 633 TAAATSTPV 641
>NP_001129521
          Length = 692

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AMATSTPI 9
          A ATSTP+
Sbjct: 49 ASATSTPV 56
>NP_149018
          Length = 655

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AMATSTPI 9
          A ATSTP+
Sbjct: 49 ASATSTPV 56
>NP_001138863
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 263 NAHATSTPL 271
>NP_060367
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 346 NAHATSTPL 354
>NP_001252538
          Length = 670

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 568 LATSTPV 574
>NP_001036111
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 642 LATSTPV 648
>NP_005564
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3 MATSTPI 9
         MAT+TP+
Sbjct: 1 MATATPV 7
>NP_055780
          Length = 686

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 584 LATSTPV 590
>NP_001252537
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 642 LATSTPV 648
>XP_006713280
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  SAMATSTPI 9
          +A ATSTP+
Sbjct: 71 NAHATSTPL 79
>XP_006713279
          Length = 459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           +A ATSTP+
Sbjct: 346 NAHATSTPL 354
>XP_006713092
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 642 LATSTPV 648
>XP_005265019
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 642 LATSTPV 648
>XP_005265017
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 642 LATSTPV 648
>XP_005265016
          Length = 849

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 538 LATSTPV 544
>XP_005265015
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 568 LATSTPV 574
>XP_005265014
          Length = 895

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MATSTPI 9
           +ATSTP+
Sbjct: 584 LATSTPV 590
>NP_001070865
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           S++ATS P+
Sbjct: 480 SSLATSAPL 488
>NP_892017
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SAMATSTPI 9
           S++ATS P+
Sbjct: 496 SSLATSAPL 504
>XP_006710008
          Length = 2014

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    SAMATSTP 8
            S+M+T+TP
Sbjct: 1551 SSMSTTTP 1558
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4     ATSTPI 9
             ATSTP+
Sbjct: 12044 ATSTPV 12049
>NP_001180451
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 775 AMAVQTPV 782
>NP_001180453
          Length = 1233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 785 AMAVQTPV 792
>NP_001180452
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 791 AMAVQTPV 798
>NP_078795
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 771 AMAVQTPV 778
>NP_689678
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 174 TSMATGTP 181
>XP_006723004
          Length = 6443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ATSTPI 9
            ATSTP+
Sbjct: 3980 ATSTPV 3985
>XP_005257989
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 176 TSMATGTP 183
>XP_006721787
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 102 TSMATGTP 109
>XP_005257987
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 102 TSMATGTP 109
>XP_005257986
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 102 TSMATGTP 109
>XP_005257985
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 102 TSMATGTP 109
>XP_006721786
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 199 TSMATGTP 206
>XP_005257984
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SAMATSTP 8
           ++MAT TP
Sbjct: 202 TSMATGTP 209
>XP_006721333
          Length = 1238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 791 AMAVQTPV 798
>XP_006721332
          Length = 1239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AMATSTPI 9
           AMA  TP+
Sbjct: 791 AMAVQTPV 798
>NP_112217
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    AMATSTP 8
            +M+TSTP
Sbjct: 1040 SMSTSTP 1046
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.102    0.254 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 428,367
Number of extensions: 417
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package